Aberrant Expression of miR-323a-5p in Patients with Refractory Epilepsy Caused by Focal Cortical Dysplasia

2017 ◽  
Vol 21 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Ningwei Che ◽  
Guo Zu ◽  
Tingting Zhou ◽  
Xiaofeng Wang ◽  
Yuqiang Sun ◽  
...  
Keyword(s):  
Refractory Epilepsy ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Aberrant Expression

Multinodular and vacuolating neuronal tumor associated with focal cortical dysplasia in a child with refractory epilepsy: a case report and brief review of literature

2020 ◽  
Vol 36 (7) ◽  
pp. 1557-1561 ◽  
Author(s):  
Lídia Nunes Dias ◽  
Santiago Candela-Cantó ◽  
Cristina Jou ◽  
Javier Aparicio Calvo ◽  
Sergio García-García ◽  
...  
Keyword(s):  
Case Report ◽  
Refractory Epilepsy ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Review Of Literature ◽  
Neuronal Tumor

Enhanced MR conspicuity of Type IIb focal cortical dysplasia by T1WI with CHESS: Two case reports

2020 ◽  
pp. 10.1212/CPJ.0000000000000987
Author(s):  
Midori Kusama ◽  
Noriko Sato ◽  
Zen-ichi Tanei ◽  
Yukio Kimura ◽  
Masaki Iwasaki ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chemical Shift ◽  
Refractory Epilepsy ◽  
Focal Cortical Dysplasia ◽  
Case Reports ◽  
Cortical Dysplasia ◽  
Fat Suppression ◽  
Developmental Anomaly ◽  
Mri Findings ◽  
Mr Sequences

Focal cortical dysplasia (FCD) is a congenital developmental anomaly that is one of the leading causes of refractory epilepsy. MRI is an essential examination and T1WI, T2WI, and FLAIR images are commonly used MR sequences for delineating FCD.1 However, these MRI findings are often insufficiently clear. We experienced two FCD cases that were much better visualized by using T1WI with chemical shift selective (CHESS) than with T2WI and FLAIR images. CHESS is the most frequently used fat suppression pulse in clinical practice. We report two cases in which CHESS clearly demonstrated FCD, and compare the cases' pathology and MRI findings.

scholarly journals Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy

2017 ◽  
Vol 15 (4) ◽  
pp. 2049-2056 ◽  
Author(s):  
Daniel Rodrigo Marinowic ◽  
Fernanda Majolo ◽  
Alessandra Deise Sebben ◽  
Vinicius Duval Da Silva ◽  
Tiago Giuliani Lopes ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Refractory Epilepsy ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Induced Pluripotent

scholarly journals On The Use of Machine Learning Algorithms to Classify Focal Cortical Dysplasia on MRI

2021 ◽  
Author(s):  
João Guilherme Pereira ◽  
Matheus de Freitas Oliveira Baffa ◽  
Fabrício Henrique Simozo ◽  
Luiz Otavio Murta Junior ◽  
Joaquim Cezar Felipe
Keyword(s):  
Deep Neural Network ◽  
Surgical Intervention ◽  
Refractory Epilepsy ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Machine Learning Algorithms ◽  
Textural Features ◽  
Epileptogenic Zone ◽  
Neural Network Classifier ◽  
Multiple Classifiers

Refractory epilepsy is a condition characterized by epileptic seizure occurrence which cannot be controlled with antiepileptic drugs. This condition is associated with an excessive neuronal discharge produced by a group of neurons in a certain epileptogenic zone. Focal Cortical Dysplasia (FCD), usually found in these zones, was detected as one of the main causes of refractory epilepsy. In these cases, surgical intervention is necessary to minimize or eliminate the seizure occurrences. However, surgical treatment is only indicated in cases where there is complete certainty of the FCD. In order to assist neurosurgeons to detect precisely these regions, this paper aims to develop a classification method to detect FCD on MRI based on morphological and textural features from a voxel-level perspective. Multiple classifiers were tested throughout the extracted features, the best results achieved an accuracy of 91.76% using a Deep Neural Network classifier and 96.15% with J48 Decision Tree. The set of evaluating metrics showed that the results are promising.

scholarly journals Focal Cortical Dysplasia and Refractory Epilepsy: Role of Multimodality Imaging and Outcome of Surgery

2019 ◽  
Vol 40 (5) ◽  
pp. 892-898 ◽  
Author(s):  
S. Jayalakshmi ◽  
S.K. Nanda ◽  
S. Vooturi ◽  
R. Vadapalli ◽  
P. Sudhakar ◽  
...  
Keyword(s):  
Refractory Epilepsy ◽  
Focal Cortical Dysplasia ◽  
Multimodality Imaging ◽  
Cortical Dysplasia ◽  
Outcome Of Surgery
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