Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

2013 ◽  
Vol 17 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Fu Jia ◽  
Rui-Fen Sun ◽  
Qun-Hui Li ◽  
Da-Xing Wang ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Bsmi Polymorphism ◽  
Osteoporosis Risk

scholarly journals Association between vitamin D receptor BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk: an updated meta-analysis

2020 ◽  
Vol 40 (7) ◽  
Author(s):  
Bin Chen ◽  
Wang-fa Zhu ◽  
Yi-yang Mu ◽  
Biao Liu ◽  
Hong-zhuo Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Biological Factors ◽  
Vdr Polymorphism ◽  
Bsmi Polymorphism ◽  
Positive Report ◽  
Meta Analyses ◽  
Osteoporosis Risk ◽  
Positive Results

Abstract Background: Many studies have reported the association between vitamin D receptor (VDR) polymorphism and osteoporosis risk. However, their results were conflicting. Six previous meta-analyses have been published to analyze VDR BsmI, FokI, and Cdx2 polymorphisms on osteoporosis risk. However, they did not evaluate the reliability of statistically significant associations. Furthermore, a lot of new articles have been published on these themes, and therefore an updated meta-analysis was performed to further explore these issues. Objectives: To explore the association between VDR BsmI, FokI, and Cdx2 polymorphisms polymorphisms and osteoporosis risk. Methods: The odds ratios (ORs) and 95% confidence intervals (95% CIs) were pooled to evaluate the association between VDR BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk. To evaluate the credibility of statistically significant associations, we applied the false-positive report probabilities (FPRPs) test and the Venice criteria. Results: Overall, statistically significantly increased osteoporosis risk was found in Indians and women for VDR FokI polymorphism. Statistically significantly decreased osteoporosis risk was found in West Asians for VDR BsmI polymorphism. However, when we performed a sensitivity analysis after excluding low quality and Hardy–Weinberg Disequilibrium (HWD) studies, significantly decreased osteoporosis risk was only found in overall population for VDR BsmI polymorphism. Further, less-credible positive results were identified when we evaluated the credibility of positive results. Conclusion: These positive findings should be interpreted with caution and indicate that significant association may most likely result from less-credible, rather than from true associations or biological factors on the VDR BsmI and FokI polymorphisms with osteoporosis risk.

Vitamin D Receptor BsmІ Polymorphism and Ovarian Cancer Risk: A Meta-Analysis

2013 ◽  
Vol 23 (7) ◽  
pp. 1178-1183 ◽  
Author(s):  
Xue Qin ◽  
Yu Lu ◽  
Aiping Qin ◽  
Zhiping Chen ◽  
Qiliu Peng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Asian Population ◽  
European Population ◽  
Ovarian Cancer Risk ◽  
Bsmi Polymorphism ◽  
Inheritance Model ◽  
The Relationship

ObjectiveVitamin D receptor (VDR) FokI polymorphism has been reported to influence ovarian cancer (OC) susceptibility, but the association between VDR BsmI polymorphism and OC risk remains controversial. To clarify the relationship between them, we performed a meta-analysis.MethodsA comprehensive literature search was conducted to examine all the eligible studies of VDR BsmI polymorphism and OC risk. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to assess the strength of this association.ResultsSeven separate comparisons consisting of 1977 OC cases and 2832 healthy controls were included in our meta-analysis. The pooled analyses showed no significant association between VDR BsmI G/A polymorphism and OC in all of the comparisons (AA vs GG: OR, 1.01; P = 0.919; AG vs GG: OR, 1.12; P = 0.087; AG + AA vs GG: OR, 1.10; P = 0.146; AA vs AG + GG: OR, 0.96; P = 0.629). However, subgroup analysis showed a significant contribution of the dominant inheritance model to OC development in the European group: AG + AA vs GG (OR, 1.43; P = 0.029); AG vs GG (OR, 1.46; P = 0.031).ConclusionsVitamin D receptor BsmI G/A gene variant might be a moderate risk factor of OC development in the European population instead of North America or Asian population.

BsmI polymorphism of vitamin D receptor gene and cancer risk: A comprehensive meta-analysis

2014 ◽  
Vol 769 ◽  
pp. 17-34 ◽  
Author(s):  
Sara Raimondi ◽  
Elena Pasquali ◽  
Patrizia Gnagnarella ◽  
Davide Serrano ◽  
Davide Disalvatore ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Bsmi Polymorphism

scholarly journals A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Mohammed Y. Areeshi ◽  
Raju K. Mandal ◽  
Sajad A. Dar ◽  
Abdulrahman M. Alshahrani ◽  
Aqeel Ahmad ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Genetic Models ◽  
Wild Type ◽  
Vdr Gene ◽  
Bsmi Polymorphism ◽  
Increased Risk ◽  
Tuberculosis Risk

BsmI (rs1544410) polymorphism located in intron 8 at the 3′-end of the vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In the present study, an updated meta-analysis was performed to evaluate the above-said association. PubMed, Embase, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. A total of 19 studies comprising 3644 controls and 2635 cases were included in the present study. Overall no association of PTB in allelic contrast (b compared with B: P=0.285; OR =0.909, 95% CI =0.762–1.083), homozygous (bb compared with BB: P=0.881; OR =0.975, 95% CI =0.700–1.359), heterozygous (bB compared with BB: P=0.834; OR =1.017, 95% CI =0.872–1.185), dominant (bb compared with BB + Bb: P=0.451; OR =0.954, 95% CI =0.843–1.079) and recessive (bb + Bb compared with BB: P=0.983; OR =1.002, 95% CI =0.868–1.156) genetic models in comparison with wild-type allele and genotype BB were observed. However, variant allele (b compared with B: P=0.001; OR =2.289, 95% CI =1.661–3.154) showed increased risk of PTB in Asians. In conclusion, VDR BsmI polymorphism is not a risk factor for PTB in overall population. However, this polymorphism may be interrelated to an increased risk of PTB amongst Asians.

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