MTRR 66A>G Polymorphism as Maternal Risk Factor for Down Syndrome: A Meta-Analysis

2013 ◽  
Vol 17 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Márcia R. Amorim ◽  
Marcelo A. Costa Lima
Keyword(s):  
Down Syndrome ◽  
Risk Factor ◽  
Meta Analysis ◽  
Maternal Risk ◽  
Maternal Risk Factor

“Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis”

2014 ◽  
Vol 30 (1) ◽  
pp. 7-24 ◽  
Author(s):  
Upendra Yadav ◽  
Pradeep Kumar ◽  
Sushil Kumar Yadav ◽  
Om Prakash Mishra ◽  
Vandana Rai
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Folate Metabolism ◽  
Maternal Risk ◽  
Maternal Risk Factor

Screening for coeliac disease as a possible maternal risk factor for neural tube defect

2008 ◽  
Vol 49 (2) ◽  
pp. 106-108 ◽  
Author(s):  
W. Dickey ◽  
F. Stewart ◽  
J. Nelson ◽  
G. McBreen ◽  
S. A. McMillan ◽  
...  
Keyword(s):  
Risk Factor ◽  
Coeliac Disease ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Maternal Risk ◽  
Maternal Risk Factor

GASTRIC BYPASS SURGERY AS MATERNAL RISK FACTOR FOR NEURAL TUBE DEFECTS

The Lancet ◽  
1988 ◽  
Vol 331 (8586) ◽  
pp. 640-641 ◽  
Author(s):  
Louise Martin ◽  
GilbertoF. Chavez ◽  
M.J. Adams ◽  
EdwardE. Mason ◽  
JamesW. Hanson ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Maternal Risk ◽  
Maternal Risk Factor

Maternal risk factor index and cesarean delivery among women with nulliparous, term, singleton, vertex deliveries, Texas, 2015

Birth ◽  
2018 ◽  
Vol 46 (1) ◽  
pp. 182-192 ◽  
Author(s):  
Meliha Salahuddin ◽  
Dorothy J. Mandell ◽  
David L. Lakey ◽  
Catherine S. Eppes ◽  
Divya A. Patel
Keyword(s):  
Risk Factor ◽  
Cesarean Delivery ◽  
Maternal Risk ◽  
Maternal Risk Factor ◽  
Factor Index

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome — meta-analysis

Open Medicine ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. 395-408 ◽  
Author(s):  
Igor Medica ◽  
Ales Maver ◽  
Goncalo Augusto ◽  
Borut Peterlin
Keyword(s):  
Down Syndrome ◽  
Mutant Allele ◽  
Meta Analysis ◽  
Genetic Alterations ◽  
Folate Metabolism ◽  
Reproductive Age ◽  
Maternal Risk ◽  
Pubmed Database ◽  
Increased Risk ◽  
Metabolism Enzymes

AbstractFolate metabolism deficiency has been related to increased occurrence of maternal non-disjunction resulting in trisomy 21. Several polymorphisms in genes coding for folate metabolism enzymes have been investigated for association with the maternal risk of Down syndrome (DS) yielding variable results. We performed a meta-analysis of case-control studies obtained through the PubMed database. The studies on polymorphisms in the MTHFR, MTRR, MTR, RFC1 and CBS genes were included. The summary OR demonstrated a statistically significant increased risk of giving birth to a child with DS in mothers carrying the mutant allele of the MTHFR/C677T gene polymorphism (both genetic models) and in mothers homozygous for the mutant allele of the MTRR/A66G polymorphism (recessive genetic model). Analyses of other polymorphisms, MTHFR/A1298C, MTR/A2756G, RFC1/A80G, and CBS/844ins68, resulted in borderline or no statistical significance. In conclusion, our meta-analysis showed the significance of genetic alterations in the folate metabolism genes in maternal susceptibility to DS offspring. Our results suggest that the importance of folate supplementation to women in reproductive age in prevention of non-disjunction be revised. Further genetic studies on a combined effect of multiple folate metabolism genes is recommended. Additionally, more thorough studies on the haplotype analyses of genes is recommended as well, especially in populations that have not yet been investigated thus far.

scholarly journals A Maternal Risk Factor for Mother-to-Child HTLV-I Transmission: Viral Antigen-producing Capacities in Culture of Peripheral Blood and Breast Milk Cells

1995 ◽  
Vol 86 (7) ◽  
pp. 649-654 ◽  
Author(s):  
Mitsuhiro Yoshinaga ◽  
Shinji Yashiki ◽  
Toshitaka Oki ◽  
Toshinobu Fujiyoshi ◽  
Yukihiro Nagata ◽  
...  
Keyword(s):  
Risk Factor ◽  
Breast Milk ◽  
Peripheral Blood ◽  
Viral Antigen ◽  
Maternal Risk ◽  
Maternal Risk Factor ◽  
Mother To Child
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