Inflammatory Bowel Disease: Susceptibility and Disease Heterogeneity Revealed by Human Leukocyte Antigen Genotyping

2012 ◽  
Vol 16 (6) ◽  
pp. 482-487 ◽  
Author(s):  
Dorra Bouzid ◽  
Arwa Kammoun ◽  
Ali Amouri ◽  
Nadia Mahfoudh ◽  
Samy Haddouk ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Human Leukocyte Antigen ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Human Leukocyte ◽  
Disease Heterogeneity ◽  
Leukocyte Antigen ◽  
Inflammatory Bowel

scholarly journals Establishing a Causal Link between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Review of the Literature

2016 ◽  
Vol 4 (2) ◽  
pp. 55-63
Author(s):  
Jaclyn Rivington ◽  
Michael Gillett
Keyword(s):  
Inflammatory Bowel Disease ◽  
Ankylosing Spondylitis ◽  
Human Leukocyte Antigen ◽  
Bowel Disease ◽  
Human Leukocyte ◽  
Active Role ◽  
Causal Link ◽  
Leukocyte Antigen ◽  
Pubmed Database ◽  
Inflammatory Bowel

The link between ankylosing spondylitis and inflammatory bowel disease is unclear, however it is hypothesized that there is a causal link between the inheritance of a human leukocyte antigen B27 allele and the development of inflammatory bowel disease symptoms in ankylosing spondylitis patients. Research articles assessing the relationship between ankylosing spondylitis, inflammatory bowel disease and the human leukocyte antigen B27 antigen were collected from the PubMed database. Patients expressing the human leukocyte antigen B27 allele have a demonstrated predisposition to developing symptoms of inflammatory bowel disease and sacroiliitis in ankylosing spondylitis. However, human leukocyte antigen B27 is considered to be just a contributing factor in the disease, as interleukin-23, natural killer cells, and alterations to the microbiome have also demonstrated an active role in the development of symptoms. More longitudinal studies using larger cohorts are needed to further substantiate a direct causal relationship between ankylosing spondylitis and inflammatory bowel disease.

scholarly journals Genetic polymorphism of HLA-G gene (G*01:03, G*01:04, and G*01:05N) in Iraqi patients with inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sarah S. Abdul-Hussein ◽  
Ekhlass N. Ali ◽  
Neihaya H. Zaki ◽  
Ali H. Ad’hiah
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Increased Risk ◽  
Soluble Hla ◽  
Inflammatory Bowel

Abstract Background Human leukocyte antigen-G (HLA-G) has been proposed to influence susceptibility to inflammatory bowel disease (IBD). Therefore, the genetic association between HLA-G alleles and two clinical phenotypes of IBD (ulcerative colitis [UC] and Crohn’s disease [CD]) was evaluated in Iraqi patients. A case-control study was performed on 50 UC and 50 CD patients and 100 healthy controls (HC). Three HLA-G alleles (G*01:03, G*01:04, and G*01:05N) were determined using sequence-specific polymerase chain reaction assay followed by product digestion with restriction endonucleases (Hinf-I, BseR-I, and PpuM-I, respectively). Results The G*01:03 allele was not detected in IBD patients (UC and CD) or HC, while G*01:04 and G*01:05N alleles showed polymorphic frequencies. The allele G*01:04 was significantly associated with susceptibility to UC (odds ratio [OR] = 2.55; 95% confidence interval [CI] = 1.27–5.13; corrected probability [pc] = 0.018) and CD (OR = 4.45; 95% CI = 2.11–9.41; pc < 0.001). The allele G*01:05N was also associated with increased risk of UC (OR = 4.17; 95% CI = 1.32–13.21; pc = 0.032) and CD (OR = 4.75; 95% CI = 1.53–14.78; pc = 0.014). These associations were more pronounced in IBD (UC + CD), and a significantly increased risk for IBD was found with the alleles G*01:04 (OR = 3.32; 95% CI = 1.86–5.95; pc < 0.001) and G*01:05N (OR = 4.46; 95% CI = 1.59–12.47; pc = 0.008). A stratification of IBD patients according to some demographic and clinical characteristics revealed that frequencies of both alleles showed no significant differences between the subgroups of patients in each stratum. Soluble HLA-G was not influenced by HLA-G alleles in patients or HC. UC was an exception, and the presence of G*01:04 allele was associated with a significantly higher mean of soluble HLA-G compared to patients without the allele (189.6 ± 24.0 vs. 168.6 ± 27.2 ng/mL; p = 0.033). Conclusion This study indicated that HLA-G*01:04 and HLA-G*01:05N alleles may influence susceptibility to UC and CD in Iraqi patients.

scholarly journals New Concepts of Pathogenesis in Inflammatory Bowel Disease

1995 ◽  
Vol 9 (5) ◽  
pp. 261-270
Author(s):  
Claudio Fiocchi
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Measles Virus ◽  
Human Leukocyte ◽  
Basic Research ◽  
Leukocyte Antigen ◽  
New Concepts ◽  
Inflammatory Bowel ◽  
Immunological Factors ◽  
Low Incidence

The precise etiology and mechanisms of inflammatory bowel disease (IBD) are still unclear. Nevertheless, several concepts are gaining acceptance and constitute the basis for a better understanding of its pathogenesis and for improved therapy. The association of Crohn’s disease (CD) and ulcerative colitis (UC) with ‘western’ lifestyle is well recognized, and is considered a reason for the increasing frequency of CD and UC in countries with previously low incidence. Proposed linkages of CD and UC with particular human leukocyte antigen haplotypes suggest a genetic predisposition, but no uniform or consistent patterns have emerged. Similarly, the study of susceptibility or disease markers has not offered reproducible results. The search for specific infectious agents is being pursued, and the measles virus is presently considered a possible culprit. A true explosion has occurred in the area of animal models, and a large number of chemically or genetically induced experimental colitides are at hand. Immunological factors continue to dominate the bulk of basic research in IBD. This area is vast and complex, and autoantibodies, immune, epithelial and mesenchymal cells, lipid mediators, cytokines, neuropeptides and oxygen metabolites are under investigation. Finally, other factors whose role in IBD is uncertain, including smoking and possible abnormalities of intestinal permeability or mucus composition, continue to receive attention. These extensive and varied efforts are yielding some profits, and new forms of therapy are being devised. Based mostly on studies of soluble mediators, a number of novel immunosuppressive and highly specific blocking agents are being developed and undergoing clinical trials.

scholarly journals Identification of novel loci controlling inflammatory bowel disease susceptibility utilizing the genetic diversity of wild-derived mice

2020 ◽  
Vol 21 (5) ◽  
pp. 311-325
Author(s):  
Karolyn G. Lahue ◽  
Montana K. Lara ◽  
Alisha A. Linton ◽  
Brigitte Lavoie ◽  
Qian Fang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Inflammatory Bowel
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