scholarly journals Involvement of Single-Nucleotide Polymorphisms in Predisposition to Head and Neck Cancer in Saudi Arabia

2012 ◽  
Vol 16 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Khaled S. Al-Hadyan ◽  
Najla M. Al-Harbi ◽  
Sara S. Al-Qahtani ◽  
Ghazi A. Alsbeih
Keyword(s):  
Saudi Arabia ◽  
Head And Neck Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Relationship of single nucleotide polymorphisms and haplotype interaction of mitochondrial unfolded protein response pathway genes with head and neck cancer

2019 ◽  
Vol 15 (33) ◽  
pp. 3819-3829
Author(s):  
Malik Waqar Ahmed ◽  
Ishrat Mahjabeen ◽  
Shazma Gul ◽  
Anum Khursheed ◽  
Azhar Mehmood ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Head And Neck ◽  
Unfolded Protein Response ◽  
Neck Cancer ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

Aim: In this study, we evaluated the effect of selected polymorphisms of mitochondrial unfolded protein response (UPRmt) pathway in 500 head and neck cancer (HNC) patients and 500 healthy controls from Pakistan. Materials & methods: The experiments were conducted using tetra-ARMS PCR followed by DNA sequencing. Results: Multivariate analysis showed that AA genotype of rs3782116 showed fivefold, GG genotype of rs6598072 approximately twofold and CC genotype of rs4946936 and TT genotype of rs12212067 showed twofold increased risk of HNC. Furthermore, haplotype analysis showed that certain haplotypes of UPRmt pathway single nucleotide polymorphisms have significant association with increased HNC risk. Conclusion: These results show that genetic aberrations in UPRmt pathway genes have association with increased HNC risk and can be an indicator of advance clinical outcome especially invasion and metastasis.

XPC, XPD/ERCC2, UMPS, CYP1b1 and XRCC5, single nucleotide polymorphisms (SNPs) in head and neck cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5588-5588
Author(s):  
J. Carles ◽  
M. Monzo ◽  
R. Artells ◽  
M. Amat ◽  
P. Foro ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Single Nucleotide Polymorphisms of XRCC1 and the Risk of Head and Neck Cancer

2018 ◽  
Author(s):  
VV Narayana Rao ◽  
Sailaja Boddikuri ◽  
Vishnuvardhan Zakkula ◽  
Madan Ranjith Pusapati ◽  
Kereena Chukka
Keyword(s):  
Head And Neck Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

XPC, XPD/ERCC2, UMPS, CYP1b1 and XRCC5, single nucleotide polymorphisms (SNPs) in head and neck cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5588-5588 ◽  
Author(s):  
J. Carles ◽  
M. Monzo ◽  
R. Artells ◽  
M. Amat ◽  
P. Foro ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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