Telephone Genetic Counseling for High-Risk Women Undergoing BRCA1 and BRCA2 Testing: Rationale and Development of a Randomized Controlled Trial

2008 ◽  
Vol 12 (1) ◽  
pp. 37-52 ◽  
Author(s):  
Beth N. Peshkin ◽  
Tiffani A. DeMarco ◽  
Kristi D. Graves ◽  
Karen Brown ◽  
Rachel H. Nusbaum ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Genetic Counseling ◽  
High Risk ◽  
Controlled Trial ◽  
Brca1 And Brca2 ◽  
High Risk Women ◽  
Randomized Controlled ◽  
Brca1 And Brca2 Testing

Telephone Genetic Counseling for High-Risk Women UndergoingBRCA1andBRCA2Testing: Rationale and Development of a Randomized Controlled Trial

2008 ◽  
Vol 0 (0) ◽  
pp. 080327164308306 ◽  
Author(s):  
Beth N. Peshkin ◽  
Tiffani A. DeMarco ◽  
Kristi D. Graves ◽  
Karen Brown ◽  
Rachel H. Nusbaum ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Genetic Counseling ◽  
High Risk ◽  
Controlled Trial ◽  
High Risk Women ◽  
Randomized Controlled

scholarly journals The effect of referral for genetic counseling on genetic testing and surgical prevention in women at high risk for ovarian cancer: Results from a randomized controlled trial

Cancer ◽  
2016 ◽  
Vol 122 (22) ◽  
pp. 3509-3518 ◽  
Author(s):  
Charles W. Drescher ◽  
J. David Beatty ◽  
Robert Resta ◽  
M. Robyn Andersen ◽  
Kate Watabayashi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Randomized Controlled Trial ◽  
Genetic Counseling ◽  
Genetic Testing ◽  
High Risk ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Surgical Prevention

Satisfaction with Team Midwifery Care for Low- and High-Risk Women: A Randomized Controlled Trial

Birth ◽  
2003 ◽  
Vol 30 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Mary Anne Biró ◽  
Ulla Waldenström ◽  
Stephanie Brown ◽  
Jan H. Pannifex
Keyword(s):  
Randomized Controlled Trial ◽  
High Risk ◽  
Controlled Trial ◽  
Midwifery Care ◽  
High Risk Women ◽  
Randomized Controlled

scholarly journals A Patient-Controlled Intravenous Analgesia With Tramadol Ameliorates Postpartum Depression in High-Risk Woman After Cesarean Section: A Randomized Controlled Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhuoxi Wu ◽  
Peng Zhao ◽  
Jing Peng ◽  
Liang Fang ◽  
Jinping Ding ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
High Risk ◽  
Postpartum Depression ◽  
Cesarean Section ◽  
Controlled Trial ◽  
Depression Scale ◽  
Clinical Trial Registration ◽  
High Risk Women ◽  
Randomized Controlled ◽  
Intravenous Analgesia

Background: Postpartum depression (PPD) is a severe psychiatric disorder. Its risk is associated with the cesarean section (CS). Currently, there are few early intervention strategies for these women with PPD who underwent CS.Methods: This was a parallel-group randomized controlled trial of singleton pregnant women who underwent elective CS in a tertiary referral hospital in China from October, 2017 to September, 2019. After operation, patients received randomly tramadol patient-controlled intravenous analgesia (PCIA; 4 mg/ml; TRA group), hydromorphone PCIA (0.04 mg/ml; HYD group), or ropivacaine patient-controlled epidural analgesia (PCEA; 1.5 mg/ml; ROP group) for 48 h in a 1:1:1 ratio. Total blinding during hospitalization was not feasible due to differences between the PCEA and PCIA treatments. All investigators who performed the follow-up were blinded to the group assignment.Outcomes: A total of 1,230 patients were enrolled for eligibility. Intention-to-treat analysis showed reduced incidence of PPD in the TRA group (n = 27 [6.6%]) than that in the HYD (10.2%, OR 1.62, 95% CI 0.98~2.68; p = 0.059) and ROP groups (10.5%, OR 1.66, 95% CI 1.01~2.75; p = 0.046) at 4 weeks post-operation, however, the difference was not statistically significant (Bonferroni corrected p = 0.118, p = 0.098, respectively). Subgroup analysis in high-risk women (preoperative Edinburgh Postpartum Depression Scale [EPDS] ≥10) showed a significantly lower incidence of PPD in the TRA group (16.5%) than in the HYD (32.6%) and ROP groups (30.9%) (Bonferroni corrected p = 0.022 and p = 0.038, respectively). The per-protocol analysis yielded similar results. Reported adverse events (AEs) were mostly mild. None of the women or infant discontinued treatment due to AEs.Conclusions: Tramadol PCIA after CS in high-risk women can help to reduce the risk of PPD at 4 weeks after elective CS.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT03309163?term=ETPPD&draw=2&rank=1; ClinicalTrials.gov (NCT03309163).

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