Renal Papillary Mapping and Quantification of Randall's Plaque in Pediatric Calcium Oxalate Stone Formers

2019 ◽  
Vol 33 (10) ◽  
pp. 863-867
Author(s):  
Anne Darves-Bornoz ◽  
Tracy Marien ◽  
John Thomas ◽  
Gabriel Fiscus ◽  
John Brock ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Stone ◽  
Randall’S Plaque ◽  
Stone Formers ◽  
Randall's Plaque

scholarly journals Papillary Pathology in Calcium Oxalate Stone Formers Who Do and Do Not Form Their Stones on Randall’s Plaque

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Haider N. Al-Awadi, BS ◽  
James C. Williams, Jr., PhD
Keyword(s):  
Calcium Oxalate ◽  
Surface Area ◽  
Stone Formation ◽  
Lower Percentage ◽  
Still Images ◽  
Calcium Oxalate Stone ◽  
Randall’S Plaque ◽  
Stone Formers ◽  
Patient Groups ◽  
Randall's Plaque

Background and Hypothesis: Nephrolithiasis currently affects about one-in-eleven people with a recurrence in up to half of those individuals. Formation of calcium oxalate (CaOx) stone is most common. Some CaOx stones are known to form on Randall’s plaque, which is a calcification of the renal papilla, and this kind of stone can be identified by morphology. We divided CaOx stone formers into two groups: Randall’s plaque (RP) stone formers (RPSF) and non-Randall’s plaque stone formers (NRPSF). We hypothesized that renal papillary pathologies would be different between these two groups of stone formers. Experimental Design or Project Methods: Surgical videos were assessed for papillary pathology using a semiquantitative grading system to measure papillary appearance in terms of ductal plugging and dilation, tissue surface pitting, loss of papillary contour, and RP. The second measure computed the papillary percent surface area of Randall’s plaque and ductal plugging using still images of the papilla. The scoring and quantitative measures of the papillae were compared between the two patient groups. All work was done in a manner blinded to the patient group. Results: Two-tailed t-test showed that RPSF group had higher scores of pitting and RP and lower scores for plugging when compared to the NRPSF group. Similarly, the quantitative data showed that RPSF group had a lower percentage of plugging surface area and higher percentage of RP surface area. Conclusion and Potential Impact: These data show that persons forming their CaOx stones primarily on RP have a papillary pathology that differs from CaOx stone formers who make their stones by other mechanisms. RPSF have more RP and less ductal plugging. Since the underlying pathologies existing in RP stone formation are different from other CaOx stone formers, it is possible that certain treatments could be especially effective for this group, and thus these results suggest that clinical trials that separate out this group of CaOx stone formers are warranted.

scholarly journals MP07-15 CALCIUM OXALATE STONE FORMERS WHO MAKE EVEN ONE STONE ON RANDALL'S PLAQUE HAVE SMALLER STONE BURDENS AND DISTINCTIVE PAPILLARY MINERAL PATHOLOGY

2021 ◽  
Vol 206 (Supplement 3) ◽  
Author(s):  
James Williams ◽  
Haider Al-Awadi ◽  
Manognya Muthenini ◽  
Sharon Bledsoe ◽  
Tarek El-Achkar ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Stone ◽  
Randall’S Plaque ◽  
Stone Formers ◽  
Randall's Plaque

scholarly journals MP19-17 RENAL PAPILLARY MAPPING AND QUANTIFICATION OF RANDALL’S PLAQUE IN PEDIATRIC CALCIUM OXALATE STONE FORMERS

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Annie Darves-Bornoz ◽  
John Thomas ◽  
Tracy Marien ◽  
Gabriel Fiscus ◽  
Douglass Clayton ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Stone ◽  
Randall’S Plaque ◽  
Stone Formers ◽  
Randall's Plaque

IN COMMON CALCIUM OXALATE STONE FORMERS, UNATTACHED STONES SHOW EVIDENCE OF HAVING ORIGINATED AS ATTACHED STONES ON RANDALL'S PLAQUE: A MICRO CT STUDY

2008 ◽  
Vol 179 (4S) ◽  
pp. 587-588 ◽  
Author(s):  
Nicole L Miller ◽  
James C Williams ◽  
Mitchell R Humphreys ◽  
Sharon B Bledsoe ◽  
Shelly E Handa ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Micro Ct ◽  
Calcium Oxalate Stone ◽  
Randall’S Plaque ◽  
Stone Formers ◽  
Show Evidence ◽  
Randall's Plaque

scholarly journals Distinguishing Characteristics of Idiopathic Calcium Oxalate Kidney Stone Formers with Low Amounts of Randall's Plaque

2014 ◽  
Vol 9 (10) ◽  
pp. 1757-1763 ◽  
Author(s):  
Xiangling Wang ◽  
Amy E. Krambeck ◽  
James C. Williams ◽  
Xiaojing Tang ◽  
Andrew D. Rule ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Randall’S Plaque ◽  
Stone Formers ◽  
Randall's Plaque

scholarly journals Randall’s plaque as the origin of idiopathic calcium oxalate stone formation: an update

2021 ◽  
Vol 24 (S2) ◽  
pp. 1-19
Author(s):  
Els Van de Perre ◽  
Dominique Bazin ◽  
Vincent Estrade ◽  
Elise Bouderlique ◽  
Karl Martin Wissing ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Stone Formation ◽  
Calcium Oxalate Stone ◽  
Randall’S Plaque ◽  
Randall's Plaque
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