Endoscopic Intravesical Fibrin Glue Application in the Treatment of Refractory Hemorrhagic Radiation Cystitis: A Single Cohort Pilot Study

2019 ◽  
Vol 33 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Pierluigi Bove ◽  
Valerio Iacovelli ◽  
Maria Cristina Tirindelli ◽  
Daniele Bianchi ◽  
Gerardo Paolo Flammia ◽  
...  
Keyword(s):  
Pilot Study ◽  
Fibrin Glue ◽  
Radiation Cystitis ◽  
Single Cohort

Fibrin glue for the suture-less correction of penile chordee: a pilot study in a rabbit model

2004 ◽  
Vol 94 (3) ◽  
pp. 433-436 ◽  
Author(s):  
Ashraf T. Hafez ◽  
Ahmed El-Assmy ◽  
Mohamed A. El-Hamid
Keyword(s):  
Pilot Study ◽  
Fibrin Glue ◽  
Rabbit Model

scholarly journals A Mobile App Specifically Designed to Facilitate Exercise in Parkinson Disease: Single-Cohort Pilot Study on Feasibility, Safety, and Signal of Efficacy

10.2196/18985 ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. e18985
Author(s):  
Merrill R Landers ◽  
Terry D Ellis
Keyword(s):  
Pilot Study ◽  
Adverse Events ◽  
Parkinson Disease ◽  
Exercise Program ◽  
Mobile App ◽  
Medical Attention ◽  
Timed Up And Go ◽  
Serious Adverse Events ◽  
Primary Endpoints ◽  
Single Cohort

Background Many people with Parkinson disease do not have access to exercise programs that are specifically tailored to their needs and capabilities. This mobile app allows people with Parkinson disease to access Parkinson disease–specific exercises that are individually tailored using in-app demographic questions and performance tests which are fed into an algorithm which in turn produces a video-guided exercise program. Objective To test the feasibility, safety, and signal of efficacy of a mobile app that facilitates exercise for people with Parkinson disease. Methods A prospective, single-cohort design of people with Parkinson disease who had downloaded the 9zest app for exercise was used for this 12-week pilot study. Participants, who were recruited online, were encouraged to exercise with the full automated app for ≥150 minutes each week. The primary endpoints were feasibility (app usage and usability questions) and safety (adverse events and falls). The primary endpoints for signal of efficacy were a comparison of the in-app baseline and 8-week outcomes on the 30-second Sit-To-Stand (STS) test, Timed Up and Go (TUG) test, and the Parkinson’s Disease Questionnaire 8 (PDQ8). Results For feasibility, of the 28 participants that completed the study, 12 participants averaged >150 minutes of app usage per week (3 averaged 120-150, 4 averaged 90-120, and 9 averaged less than 90 minutes). A majority of participants (>74%) felt the exercise was of value (16/19; 9 nonrespondents), provided adequate instruction (14/19; 9 nonrespondents), and was appropriate for level of function (16/19; 9 nonrespondents). For safety, there were no serious adverse events that occurred during the app-guided exercise. There were 4 reports of strain/sprain injuries while using the app among 3 participants, none of which necessitated medical attention. For signal of efficacy, there was improvement for each of the primary endpoints: STS (P=.01), TUG (P<.001), and PDQ8 (P=.01). Conclusions Independent, video-guided exercise using a mobile app designed for exercise in Parkinson disease was safe and feasible though there was variability in app usage. Despite this, the results provide evidence for a signal of efficacy as there were improvements in 3 of the 3 outcomes. Trial Registration ClinicalTrials.gov NCT03459586; https://clinicaltrials.gov/ct2/show/NCT03459586

scholarly journals Endoscopic closure of refractory esophageal fistula after esophagectomy using polyglycolic acid sheets: a pilot study

2020 ◽  
Vol 08 (05) ◽  
pp. E591-E595 ◽  
Author(s):  
Yasuaki Nagami ◽  
Masaki Ominami ◽  
Taishi Sakai ◽  
Shusei Fukunaga ◽  
Fumio Tanaka ◽  
...  
Keyword(s):  
Pilot Study ◽  
Adverse Events ◽  
Fibrin Glue ◽  
Polyglycolic Acid ◽  
Poor Quality ◽  
Esophageal Fistula ◽  
Fistula Closure ◽  
Prospective Pilot Study ◽  
Endoscopic Closure

Abstract Background and study aims Esophageal fistulas after esophagectomy are associated with high mortality and poor quality of life. They are sometimes intractable to conservative management and surgery that increases mortality. Few studies have assessed use of polyglycolic acid (PGA) sheets with fibrin glue for esophageal fistulas. We investigated the safety of using PGA sheets with fibrin glue for esophageal fistulas after esophagectomy. Patients and methods This was a single-center prospective pilot study. Patients who had refractory esophageal fistulas after esophagectomy were included. PGA sheets were filled in the fistula using biopsy forceps. Fibrin glue was applied to the PGA sheets. We repeated the procedure 1 week later. The outcome measures were the incidence of adverse events (AEs) and closure of the fistula. Results Five patients were assessed. No adverse events were observed. The esophageal fistula was closed with the application of PGA sheets four times in 40 % (2/5) of the cases. Conclusions PGA sheets with fibrin glue were safe for esophageal fistula closure after esophagectomy and do not involve the risk of AEs.

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