scholarly journals Effect of Dietary Control of Urinary Uric Acid Excretion in Calcium Oxalate Stone Formers and Non-Stone-Forming Controls

2007 ◽  
Vol 21 (2) ◽  
pp. 232-235 ◽  
Author(s):  
Vernon M. Pais ◽  
Ross P. Holmes ◽  
Dean G. Assimos
Keyword(s):  
Uric Acid ◽  
Calcium Oxalate ◽  
Dietary Control ◽  
Acid Excretion ◽  
Calcium Oxalate Stone ◽  
Uric Acid Excretion ◽  
Stone Formers

scholarly journals Weekend versus Weekday Urine Collections in Assessment of Stone-Formers

1996 ◽  
Vol 89 (10) ◽  
pp. 561-562 ◽  
Author(s):  
Richard W Norman
Keyword(s):  
Uric Acid ◽  
Calcium Oxalate ◽  
Urine Volume ◽  
Acid Excretion ◽  
Metabolic Evaluation ◽  
Uric Acid Excretion ◽  
Stone Formers ◽  
Increased Risk ◽  
Working Day

Twenty-four-hour urine collections are an important part of the metabolic evaluation of stone-formers, but are difficult for patients at work. At weekends the results might be different. Forty-five stone-formers who worked at day jobs from Monday to Friday collected urine for 24 h on a normal working day and also on a Saturday or Sunday and the differences were evaluated. Average 24 h urine volume was higher on weekdays than at weekends. Calcium, oxalate, and uric acid excretion did not differ. These results imply an increased risk of crystalluria at the weekend. Therefore weekend collections are most likely to show abnormalities and should be acceptable to clinicians.

Increased urinary uric acid excretion: a finding in Indian stone formers

2009 ◽  
Vol 38 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Tapan Sinha ◽  
S. C. Karan ◽  
Atul Kotwal
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Stone Formers

Tubular Urate Transporter Gene Polymorphisms Differentiate Patients with Gout Who Have Normal and Decreased Urinary Uric Acid Excretion

2014 ◽  
Vol 41 (9) ◽  
pp. 1863-1870 ◽  
Author(s):  
Rosa J. Torres ◽  
Eugenio de Miguel ◽  
Rebeca Bailén ◽  
José R. Banegas ◽  
Juan G. Puig
Keyword(s):  
Uric Acid ◽  
Tubular Secretion ◽  
Dietary Control ◽  
Nucleotide Polymorphisms ◽  
Transporter Gene ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Control Subjects ◽  
Urate Transporter ◽  
Primary Gout

Objective.Primary gout has been associated with single-nucleotide polymorphisms (SNP) in several tubular urate transporter genes. No study has assessed the association of reabsorption and secretion urate transporter gene SNP with gout in a single cohort of documented primary patients with gout carefully subclassified as normoexcretors or underexcretors.Methods.Three reabsorption SNP (SLC22A12/URAT1, SLC2A9/GLUT9, and SLC22A11/OAT4) and 2 secretion transporter SNP (SLC17A1/NPT1 and ABCG2/BRCP) were studied in 104 patients with primary gout and in 300 control subjects. The patients were subclassified into normoexcretors and underexcretors according to their serum and 24-h urinary uric acid levels under strict conditions of dietary control.Results.Compared with control subjects, patients with gout showed different allele distributions of the 5 SNP analyzed. However, the diagnosis of underexcretor was only positively associated with the presence of the T allele of URAT1 rs11231825, the G allele of GLUT9 rs16890979, and the A allele of ABCG2 rs2231142. The association of the A allele of ABCG2 rs2231142 in normoexcretors was 10 times higher than in underexcretors. The C allele of NPT1 rs1165196 was only significantly associated with gout in patients with normal uric acid excretion.Conclusion.Gout with uric acid underexcretion is associated with transporter gene SNP related mainly to tubular reabsorption, whereas uric acid normoexcretion is associated only with tubular secretion SNP. This finding supports the concept of distinctive mechanisms to account for hyperuricemia in patients with gout with reduced or normal uric acid excretion.

1039: Effect of Dietary Control on Urinary Uric Acid Excretion

2006 ◽  
Vol 175 (4S) ◽  
pp. 334-334
Author(s):  
Vernon M. Pais ◽  
Ross P. Holmes ◽  
Dean G. Assimos
Keyword(s):  
Uric Acid ◽  
Dietary Control ◽  
Acid Excretion ◽  
Uric Acid Excretion
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