Inhibition of Peritoneal Tumor-Cell Implantation: Model for Laparoscopic Cancer Surgery

1993 ◽  
Vol 7 (3) ◽  
pp. 237-241 ◽  
Author(s):  
DAVID S. GOLDSTEIN ◽  
MICHAEL L. LU ◽  
TOMOTAKA HATTORI ◽  
TIMOTHY L. RATLIFF ◽  
KEVIN R. LOUGHLIN ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cancer Surgery ◽  
Tumor Cell Implantation ◽  
Peritoneal Tumor ◽  
Implantation Model ◽  
Cell Implantation

Novel Concept of Electrocoagulation and Tumor Cell Implantation: Creation of Minimally Invasive Orthotopic Murine Model of Pancreatic Cancer

2015 ◽  
Vol 221 (4) ◽  
pp. S93
Author(s):  
Jasneet S. Bhullar ◽  
Yaniv Cozakov ◽  
Neha Varshney ◽  
Sandiya Bindroo ◽  
Gokulakkrishna Subhas ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Minimally Invasive ◽  
Tumor Cell ◽  
Murine Model ◽  
Tumor Cell Implantation ◽  
Novel Concept ◽  
Cell Implantation

Sucralfate Inhibition of Tumor Cell Implantation in the Murine Urinary Bladder

1988 ◽  
Vol 140 (1) ◽  
pp. 188-190 ◽  
Author(s):  
Marvin J. Van Every ◽  
Alvin L. Sago ◽  
William J. Ehler ◽  
Donald E. Novicki
Keyword(s):  
Urinary Bladder ◽  
Tumor Cell ◽  
Tumor Cell Implantation ◽  
Cell Implantation

Urothelial susceptibility to tumor cell implantation: comparison of cauterization with N-methyl-N-nitrosourea

Urology ◽  
1983 ◽  
Vol 21 (2) ◽  
pp. 159-161 ◽  
Author(s):  
Mark S. Soloway ◽  
Israel Nissenkorn ◽  
Lee McCallum
Keyword(s):  
Tumor Cell ◽  
Tumor Cell Implantation ◽  
Cell Implantation

scholarly journals Chemokine receptor CXCR4 activates the RhoA/ROCK2 pathway in spinal neurons that induces bone cancer pain

2020 ◽  
Vol 16 ◽  
pp. 174480692091956 ◽  
Author(s):  
Heng Xu ◽  
Chong Peng ◽  
Xue-Tai Chen ◽  
Ying-Ying Yao ◽  
Li-Ping Chen ◽  
...  
Keyword(s):  
Body Weight ◽  
Cancer Pain ◽  
Tumor Cell ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Sprague Dawley ◽  
Tumor Cell Implantation ◽  
Sprague Dawley Rats ◽  
Gland Carcinoma ◽  
Cell Implantation

Background Chemokine receptor CXCR4 has been found to be associated with spinal neuron and glial cell activation during bone cancer pain. However, the underlying mechanism remains unknown. Furthermore, the RhoA/ROCK2 pathway serves as a downstream pathway activated by CXCR4 during bone cancer pain. We first validated the increase in the expressions of CXCR4, p-RhoA, and p-ROCK2 in the spinal dorsal horn of a well-characterized tumor cell implantation-induced cancer pain rat model and how these expressions contributed to the pain behavior in tumor cell implantation rats. We hypothesized that spinal blockade of the CXCR4-RhoA/ROCK2 pathway is a potential analgesic therapy for cancer pain management. Methods Adult female Sprague–Dawley rats (body weight of 180–220 g) and six- to seven-week old female Sprague–Dawley rats (body weight of 80–90 g) were taken. Ascitic cancer cells were extracted from the rats (body weight of 80–90 g) with intraperitoneally implanted Walker 256 mammary gland carcinoma cells. Walker 256 rat mammary gland carcinoma cells were then injected (tumor cell implantation) into the intramedullary space of the tibia to establish a rat model of bone cancer pain. Results We found increased expressions of CXCR4, p-RhoA, and p-ROCK2 in the neurons in the spinal cord. p-RhoA and p-ROCK2 were co-expressed in the neurons and promoted by overexpressed CXCR4. Intrathecal delivery of CXCR4 inhibitor Plerixafor (AMD3100) or ROCK2 inhibitor Fasudil abrogated tumor cell implantation-induced pain hypersensitivity and tumor cell implantation-induced increase in p-RhoA and p-ROCK2 expressions. Intrathecal injection of stromal-derived factor-1, the principal ligand for CXCR4, accelerated p-RhoA expression in naive rats, which was prevented by postadministration of CXCR4 inhibitor Plerixafor (AMD3100) or ROCK2 inhibitor Fasudil. Conclusions Collectively, the spinal RhoA/ROCK2 pathway could be a critical downstream target for CXCR4-mediated neuronal sensitization and pain hypersensitivity in bone cancer pain, and it may serve as a potent therapeutic target for pain treatment.

The role of pentoxifylline in the prevention of tumor cell implantation

1983 ◽  
Vol 23 (3) ◽  
pp. 153-154
Author(s):  
M. C. Ikossi-O'Connor ◽  
J. L. Ambrus
Keyword(s):  
Tumor Cell ◽  
Tumor Cell Implantation ◽  
Cell Implantation
Sign in / Sign up

Export Citation Format

Share Document