Preparation and Biofilm Culturing Characteristics of a Novel Porous Carrier

2020 ◽  
Author(s):  
Qibang Tong ◽  
Guixin Wang ◽  
Cihang Zheng ◽  
Maolian Chen ◽  
Yaping Chen ◽  
...  
Keyword(s):  
Porous Carrier

scholarly journals Microbial communities in biomass immobilized in the porous carrier

2009 ◽  
Vol 25 ◽  
pp. S351
Author(s):  
A. Cydzik-Kwiatkowska ◽  
M. Zielinska ◽  
I. Wojnowska-Baryla
Keyword(s):  
Microbial Communities ◽  
Porous Carrier

Nutrients adsorption from seawater by new porous carrier made from zeolitized fly ash and slag

2002 ◽  
Vol 45 (1-12) ◽  
pp. 311-315 ◽  
Author(s):  
Olfa Khelifi ◽  
Yasunori Kozuki ◽  
Hitoshi Murakami ◽  
Kengo Kurata ◽  
Mamuro Nishioka
Keyword(s):  
Fly Ash ◽  
Porous Carrier

scholarly journals Evaluation of porous carrier-based floating orlistat microspheres for gastric delivery

2006 ◽  
Vol 7 (4) ◽  
pp. E54-E62 ◽  
Author(s):  
Sunil K. Jain ◽  
Govind P. Agrawal ◽  
Narendra K. Jain
Keyword(s):  
Porous Carrier

scholarly journals Synthesis of Carbon Onion and Its Application as a Porous Carrier for Amorphous Drug Delivery

Crystals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 281
Author(s):  
Nikhila Miriyala ◽  
Daniel J. Kirby ◽  
Aude Cumont ◽  
Ruoying Zhang ◽  
Baogui Shi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Nature ◽  
Drug Carrier ◽  
Drug Loading ◽  
Sodium Dodecyl ◽  
Porous Carrier ◽  
Amorphous Form ◽  
Carbon Onion ◽  
Low Cytotoxicity ◽  
Amorphous Drug

Given the great potential of porous carrier-based drug delivery for stabilising the amorphous form of drugs and enhancing dissolution profiles, this work is focussed on the synthesis and application of carbon onion or onion-like carbon (OLC) as a porous carrier for oral amorphous drug delivery, using paracetamol (PA) and ibuprofen (IBU) as model drugs. Annealing of nanodiamonds at 1100 °C produced OLC with a diamond core that exhibited low cytotoxicity on Caco-2 cells. Solution adsorption followed by centrifugation was used for drug loading and results indicated that the initial concentration of drug in the loading solution needs to be kept below 11.5% PA and 20.7% IBU to achieve complete amorphous loading. Also, no chemical interactions between the drug and OLC could be detected, indicating the safety of loading into OLC without changing the chemical nature of the drug. Drug release was complete in the presence of sodium dodecyl sulphate (SDS) and was faster compared to the pure crystalline drug, indicating the potential of OLC as an amorphous drug carrier.

scholarly journals Use of Alternative Carrier Materials in AOAC Official MethodSM 2008.05, Efficacy of Liquid Sporicides Against Spores of Bacillus subtilis on a Hard, Nonporous Surface, Quantitative Three-Step Method

2010 ◽  
Vol 93 (1) ◽  
pp. 259-276 ◽  
Author(s):  
Stephen F Tomasino ◽  
Vipin K Rastogi ◽  
Lalena Wallace ◽  
Lisa S Smith ◽  
Martin A Hamilton ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Ceramic Tile ◽  
Step Method ◽  
Porous Carrier ◽  
Pine Wood ◽  
Log Reduction ◽  
Microcentrifuge Tube ◽  
Carrier Materials ◽  
Aoac Official ◽  
The Mean

Abstract The quantitative Three-Step Method (TSM) for testing the efficacy of liquid sporicides against spores of Bacillus subtilis on a hard, nonporous surface (glass) was adopted as AOAC Official MethodSM 2008.05 in May 2008. The TSM uses 5 5 1 mm coupons (carriers) upon which spores have been inoculated and which are introduced into liquid sporicidal agent contained in a microcentrifuge tube. Following exposure of inoculated carriers and neutralization, spores are removed from carriers in three fractions (gentle washing, fraction A; sonication, fraction B; and gentle agitation, fraction C). Liquid from each fraction is serially diluted and plated on a recovery medium for spore enumeration. The counts are summed over the three fractions to provide the density (viable spores per carrier), which is log10-transformed to arrive at the log density. The log reduction is calculated by subtracting the mean log density for treated carriers from the mean log density for control carriers. This paper presents a single-laboratory investigation conducted to evaluate the applicability of using two porous carrier materials (ceramic tile and untreated pine wood) and one alternative nonporous material (stainless steel). Glass carriers were included in the study as the reference material. Inoculated carriers were evaluated against three commercially available liquid sporicides (sodium hypochlorite, a combination of peracetic acid and hydrogen peroxide, and glutaraldehyde), each at two levels of presumed efficacy (medium and high) to provide data for assessing the responsiveness of the TSM. Three coupons of each material were evaluated across three replications at each level; three replications of a control were required. Even though all carriers were inoculated with approximately the same number of spores, the observed counts of recovered spores were consistently higher for the nonporous carriers. For control carriers, the mean log densities for the four materials ranged from 6.63 for wood to 7.14 for steel. The pairwise differences between mean log densities, except for glass minus steel, were statistically significant (P < 0.001). The repeatability standard deviations (Sr) for the mean control log density per test were similar for the four materials, ranging from 0.08 for wood to 0.13 for tile. Spore recovery from the carrier materials ranged from approximately 20 to 70: 20 (pine wood), 40 (ceramic tile), 55 (glass), and 70 (steel). Although the percent spore recovery from pine wood was significantly lower than that from other materials, the performance data indicate that the TSM provides a repeatable and responsive test for determining the efficacy of liquid sporicides on both porous and nonporous materials.

Low density porous carrier based conceptual drug delivery system

2007 ◽  
Vol 102 (1-3) ◽  
pp. 290-298 ◽  
Author(s):  
Praveen Sher ◽  
Ganesh Ingavle ◽  
Surendra Ponrathnam ◽  
Atmaram P. Pawar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Low Density ◽  
Porous Carrier

scholarly journals Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2950
Author(s):  
Ioannis Koutsamanis ◽  
Martin Spoerk ◽  
Florian Arbeiter ◽  
Simone Eder ◽  
Eva Roblegg
Keyword(s):  
Material Selection ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Controlled Delivery ◽  
Application Site ◽  
Melt Extrusion ◽  
Average Pore ◽  
Porous Carrier ◽  
Good Patient Compliance ◽  
Hot Melt

Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

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