Appropriate Dose for Degradation of Levofloxacin Lactate: Gamma Radiolysis and Assessment of Degradation Product Activity and Cytotoxicity

2011 ◽  
Vol 28 (3) ◽  
pp. 183-189 ◽  
Author(s):  
Dongmei Cao ◽  
Xiaohong Zhang ◽  
Suying Zhao ◽  
Yu Guan ◽  
Haiqian Zhang
Keyword(s):  
Degradation Product ◽  
Gamma Radiolysis ◽  
Levofloxacin Lactate

scholarly journals Hydroxyl-radical-induced iron-catalysed degradation of 2-deoxyribose. Quantitative determination of malondialdehyde

1988 ◽  
Vol 252 (3) ◽  
pp. 649-653 ◽  
Author(s):  
K H Cheeseman ◽  
A Beavis ◽  
H Esterbauer
Keyword(s):  
Quantitative Determination ◽  
Hydroxyl Radical ◽  
Hydroxyl Radicals ◽  
Degradation Product ◽  
Thiobarbituric Acid ◽  
Iron Ions ◽  
Reactive Material ◽  
Gamma Radiolysis ◽  
Deoxyribose Degradation

The degradation of 2-deoxyribose to thiobarbituric acid-reactive material was investigated with two hydroxyl-radical-generating systems: (i) a defined gamma-radiolysis method and (ii) incubation with FeSO4 in phosphate buffer. In each case the thiobarbituric acid-reactive material can be accounted for by malondialdehyde, as measured by an h.p.l.c. method for free malondialdehyde. In the radiolysis system there is a large post-irradiation increase in free malondialdehyde if iron ions are added to the samples. It is proposed that this is due to iron ions catalysing the formation of hydroxyl radicals from radiolytically generated H2O2 as well as stimulating the breakdown of an intermediate deoxyribose degradation product. A mechanism for the formation of malondialdehyde during deoxyribose degradation is proposed.

The Different Forms of Antithrombin III in Serum

1977 ◽  
Vol 38 (02) ◽  
pp. 0494-0503 ◽  
Author(s):  
D. S Pepper ◽  
D Banhegyi ◽  
J. D Cash
Keyword(s):  
Molecular Weight ◽  
Affinity Chromatography ◽  
Human Serum ◽  
Degradation Product ◽  
Antithrombin Iii ◽  
Gel Filtration ◽  
Free Form ◽  
Polymeric Form ◽  
At Iii ◽  
Human Thrombin

SummaryAntithrombin III (AT III) complexes were isolated from human serum by affinity chromatography and gel filtration. In the first step of the preparation, using heparin-agarose chromatography, we observed that the complexed form of AT III bound less strongly to the gel than the free form and that about half of the AT III was free. With further purification a 2.5 × 105 molecular weight complex was isolated. Using 125I labelled human thrombin, this complex was radioactive indicating the presence of thrombin. Only in a synthetic thrombin-AT III system was a 9 × 104 molecular weight complex detected, but not in serum. These facts suggest that in serum AT III complexes may exist in a polymeric form. Also, an AT III antigen derived from the original AT III molecule, but not complexed, was isolated which may be a degradation product.Abbreviations used: AT-III, antithrombin III. Hepes, N-2-Hydroxyethylpiperazine-N-2-Ethanesulphonic acid.

scholarly journals Gamma Radiolysis of TODGA and CyMe4BTPhen in the Ionic Liquid Tri-n-Octylmethylammonium Nitrate

2020 ◽  
Vol 38 (2) ◽  
pp. 212-235 ◽  
Author(s):  
Peter Zsabka ◽  
Karen Van Hecke ◽  
Andreas Wilden ◽  
Giuseppe Modolo ◽  
Michelle Hupert ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Gamma Radiolysis

scholarly journals Ultrasound-assisted depolymerization of kappa-carrageenan and characterization of degradation product

2021 ◽  
pp. 105540
Author(s):  
Mariel G. Tecson ◽  
Lucille V. Abad ◽  
Virgilio D. Ebajo ◽  
Drexel H. Camacho
Keyword(s):  
Degradation Product ◽  
Ultrasound Assisted ◽  
Kappa Carrageenan
Sign in / Sign up

Export Citation Format

Share Document