The Antiangiogenesis Role of Histone Deacetylase Inhibitors: Their Potential Application to Tumor Therapy and Tissue Repair

2020 ◽  
Vol 39 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Bin Deng ◽  
Qing Luo ◽  
Alexander Halim ◽  
Qiuping Liu ◽  
Bingyu Zhang ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Potential Application ◽  
Tissue Repair ◽  
Histone Deacetylase Inhibitors ◽  
Tumor Therapy

scholarly journals Epigenetic Targeting of Autophagy via HDAC Inhibition in Tumor Cells: Role of p53

2018 ◽  
Vol 19 (12) ◽  
pp. 3952 ◽  
Author(s):  
Maria Mrakovcic ◽  
Lauren Bohner ◽  
Marcel Hanisch ◽  
Leopold F. Fröhlich
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Histone Deacetylase ◽  
Stress Responses ◽  
Histone Deacetylase Inhibitors ◽  
Tumor Therapy ◽  
Regulatory System ◽  
Anticancer Activities ◽  
Mutational Status

Tumor development and progression is the consequence of genetic as well as epigenetic alterations of the cell. As part of the epigenetic regulatory system, histone acetyltransferases (HATs) and deacetylases (HDACs) drive the modification of histone as well as non-histone proteins. Derailed acetylation-mediated gene expression in cancer due to a delicate imbalance in HDAC expression can be reversed by histone deacetylase inhibitors (HDACi). Histone deacetylase inhibitors have far-reaching anticancer activities that include the induction of cell cycle arrest, the inhibition of angiogenesis, immunomodulatory responses, the inhibition of stress responses, increased generation of oxidative stress, activation of apoptosis, autophagy eliciting cell death, and even the regulation of non-coding RNA expression in malignant tumor cells. However, it remains an ongoing issue how tumor cells determine to respond to HDACi treatment by preferentially undergoing apoptosis or autophagy. In this review, we summarize HDACi-mediated mechanisms of action, particularly with respect to the induction of cell death. There is a keen interest in assessing suitable molecular factors allowing a prognosis of HDACi-mediated treatment. Addressing the results of our recent study, we highlight the role of p53 as a molecular switch driving HDACi-mediated cellular responses towards one of both types of cell death. These findings underline the importance to determine the mutational status of p53 for an effective outcome in HDACi-mediated tumor therapy.

scholarly journals Role of Histone Deacetylase Inhibitors in Relapsed Refractory Multiple Myeloma: A Focus on Vorinostat and Panobinostat

2015 ◽  
Vol 35 (12) ◽  
pp. 1173-1188 ◽  
Author(s):  
Salma Afifi ◽  
Angela Michael ◽  
Mahshid Azimi ◽  
Mabel Rodriguez ◽  
Nikoletta Lendvai ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Refractory Multiple Myeloma

Potential Role of Histone Deacetylase Inhibitors in Mesothelioma: Clinical Experience with Suberoylanilide Hydroxamic Acid

2006 ◽  
Vol 7 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Lee M. Krug ◽  
Tracy Curley ◽  
Lawrence Schwartz ◽  
Stacie Richardson ◽  
Paul Marks ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Clinical Experience ◽  
Hydroxamic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Potential Role ◽  
Suberoylanilide Hydroxamic Acid

scholarly journals Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid Malignancies

Cancers ◽  
2013 ◽  
Vol 5 (4) ◽  
pp. 919-942 ◽  
Author(s):  
Antonino Grassadonia ◽  
Pasquale Cioffi ◽  
Felice Simiele ◽  
Laura Iezzi ◽  
Marinella Zilli ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Solid Malignancies

scholarly journals Essential role of insulin-like growth factor 2 in resistance to histone deacetylase inhibitors

Oncogene ◽  
2016 ◽  
Vol 35 (42) ◽  
pp. 5515-5526 ◽  
Author(s):  
S-C Lee ◽  
H-Y Min ◽  
H J Jung ◽  
K H Park ◽  
S Y Hyun ◽  
...  
Keyword(s):  
Growth Factor ◽  
Histone Deacetylase ◽  
Essential Role ◽  
Histone Deacetylase Inhibitors ◽  
Insulin Like Growth Factor

scholarly journals Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

2005 ◽  
Vol 102 (3) ◽  
pp. 673-678 ◽  
Author(s):  
J. S. Ungerstedt ◽  
Y. Sowa ◽  
W.-S. Xu ◽  
Y. Shao ◽  
M. Dokmanovic ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Transformed Cells
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