miR-142 Suppresses Endometrial Cancer Proliferation In Vitro and In Vivo by Targeting Cyclin D1

2019 ◽  
Vol 38 (2) ◽  
pp. 144-150 ◽  
Author(s):  
Yi Su ◽  
Jing Wang ◽  
Zhao Ma ◽  
Wenjing Gong ◽  
Lianzhi Yu
Keyword(s):  
Endometrial Cancer ◽  
Cyclin D1 ◽  
Cancer Proliferation ◽  
Proliferation In Vitro

Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo

2010 ◽  
Vol 128 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Yi Chen ◽  
Edwin A. Alvarez ◽  
Diana Azzam ◽  
Seth A. Wander ◽  
Natalia Guggisberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Cancer Proliferation ◽  
Proliferation In Vitro

scholarly journals Plant-Derived MINA-05 Inhibits Human Prostate Cancer Proliferation In Vitro and Lymph Node Spread In Vivo

Neoplasia ◽  
2007 ◽  
Vol 9 (4) ◽  
pp. 322-331 ◽  
Author(s):  
Kate Vandyke ◽  
Melanie Y. White ◽  
Terry Nguyen-Khuong ◽  
Kim Ow ◽  
Sharon C.-W. Luk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Proliferation ◽  
Proliferation In Vitro

scholarly journals Long noncoding RNA PVT1 promoted gallbladder cancer proliferation by epigenetically suppressing miR-18b-5p via DNA methylation

2020 ◽  
Vol 11 (10) ◽  
Author(s):  
Longyang Jin ◽  
Qiang Cai ◽  
Shouhua Wang ◽  
Shuqing Wang ◽  
Jiandong Wang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gallbladder Cancer ◽  
Noncoding Rna ◽  
Biliary Tree ◽  
Cancer Proliferation ◽  
Downstream Target ◽  
Downstream Target Gene ◽  
Proliferation In Vitro

Abstract Gallbladder cancer (GBC) accounts for 85–90% malignancies of the biliary tree worldwide. Considerable evidence has demonstrated that dysregulation of lncRNAs is involved in the progression of cancer. LncRNA PVT1 has been reported to play important roles in various cancers, but its role in gallbladder cancer remains unknown. In the present study, we found that PVT1 was upregulated in GBC tissues and cells, and its upregulation was related with poor prognosis in GBC patients. PVT1 promoted GBC cells proliferation in vitro and in vivo. Mechanistically, PVT1 recruited DNMT1 via EZH2 to the miR-18b-5p DNA promoter and suppressed the transcription of miR-18b-5p through DNA methylation. Moreover, HIF1A was proved to be the downstream target gene of miR-18b-5p and PVT1 regulated GBC cells proliferation via HIF1A. In conclusion, our studies clarified the PVT1/miR-18b-5p/HIF1A regulation axis and indicated that PVT1 could be a potential therapeutic target for GBC.

scholarly journals siRNA-mediated knockdown against NUF2 suppresses pancreatic cancer proliferation in vitro and in vivo

2015 ◽  
Vol 35 (1) ◽  
Author(s):  
Peng Hu ◽  
Xi Chen ◽  
Jing Sun ◽  
Ping Bie ◽  
Lei-Da Zhang
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Cancer Proliferation ◽  
Promising Therapeutic Target ◽  
Cancer Tissues ◽  
Proliferation In Vitro

NUF2 is overexpressed in pancreatic cancer tissues and cell lines. siRNA-mediated knockdown against NUF2 resulted in a significant reduction in pancreatic cancer cell growth both in vitro and in vivo. NUF2 may be a promising therapeutic target in pancreatic cancer.

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