Decreased Level of Klotho Contributes to Drug Resistance in Lung Cancer Cells: Involving in Klotho-Mediated Cell Autophagy

2016 ◽  
Vol 35 (12) ◽  
pp. 751-757 ◽  
Author(s):  
TianJun Chen ◽  
Hui Ren ◽  
Asmitanand Thakur ◽  
Tian Yang ◽  
Yang Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Lung Cancer Cells

Overcoming drug-resistance in lung cancer cells by paclitaxel loaded galactoxyloglucan nanoparticles

2019 ◽  
Vol 136 ◽  
pp. 266-274 ◽  
Author(s):  
P.L. Reshma ◽  
B.S. Unnikrishnan ◽  
G.U. Preethi ◽  
H.P. Syama ◽  
M.G. Archana ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Lung Cancer Cells

Bypassing pro-survival and resistance mechanisms of autophagy in EGFR-positive lung cancer cells by targeted delivery of 5FU using theranostic Ag2S quantum dots

2019 ◽  
Vol 7 (46) ◽  
pp. 7363-7376 ◽  
Author(s):  
Fatma Demir Duman ◽  
Yunus Akkoc ◽  
Gozde Demirci ◽  
Nima Bavili ◽  
Alper Kiraz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Quantum Dots ◽  
Drug Resistance ◽  
Cell Death ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Resistance Mechanisms ◽  
Lung Cancer Cells ◽  
Ag2s Quantum Dots

Cetuximab tagged, 5FU loaded Ag2S QDs enhanced cell death selectively and overcame drug resistance by suppressing autophagy in strong EGFR overexpressing cancer cells.

scholarly journals Gefitinib-mediated Reactive Oxygen Specie (ROS) Instigates Mitochondrial Dysfunction and Drug Resistance in Lung Cancer Cells

2015 ◽  
Vol 290 (14) ◽  
pp. 9101-9110 ◽  
Author(s):  
Imoh S. Okon ◽  
Kathleen A. Coughlan ◽  
Miao Zhang ◽  
Qiongxin Wang ◽  
Ming-Hui Zou
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Lung Cancer Cells

Silence of  lncRNA UCA1 rescues drug resistance of cisplatin to non–small‐cell lung cancer cells

2019 ◽  
Vol 120 (6) ◽  
pp. 9243-9249 ◽  
Author(s):  
Xiaojing Liu ◽  
Zhisheng Huang ◽  
Wei Qian ◽  
Qing Zhang ◽  
Jian Sun
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung

scholarly journals Negative Regulation of PTEN by MicroRNA-221 and Its Association with Drug Resistance and Cellular Senescence in Lung Cancer Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Ning Wang ◽  
Chen Zhu ◽  
Ye Xu ◽  
Wenliang Qian ◽  
Min Zheng
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Cell Lines ◽  
Term Treatment ◽  
Lung Cancer Cells ◽  
Akt Pathway ◽  
Long Term Treatment ◽  
Important Regulator

Objective.Chemotherapy is the routine method for treating many cancers, but long-term treatment may result in developing resistance to the drugs. The aim of this study was to identify whether noncoding RNAs play a role in drug resistance and how they affect drug resistance.Materials and Methods.The expression levels of miR-221 in different lung cancer cell lines H226, H1299, and A549 were measured. H1299 and A549 cell lines were transfected to overexpress and downexpress miR-221, and cell viability and cell senescence were determined. The PTEN/Akt pathway was then examined by real-time polymerase chain reaction and Western blot analysis.Results. MiR-221 together with proteins MDR1 and ABCG2 was upregulated in Cisplatin-resistant A549 lung cancer cells. Anti-miR-221 inhibits proliferation and induces senescence in lung cancer cells. PTEN/Akt pathway axis was identified as a target of drug resistance induced by miR-221.Conclusion. Our results revealed that miR-221 is an important regulator for chemotherapy sensitivity and showed miR-221 as a potential target for drug sensitization.

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