Association of Angiotensin-Converting Enzyme and Angiotensin II Type I Receptor Gene Polymorphisms with Extreme Obesity in Polish Individuals

2013 ◽  
Vol 32 (8) ◽  
pp. 435-442 ◽  
Author(s):  
Marta Pacholczyk ◽  
Tomasz Ferenc ◽  
Jan Kowalski ◽  
Przemysław Adamczyk ◽  
Jacek Chojnowski ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Type I ◽  
Converting Enzyme ◽  
Extreme Obesity ◽  
Receptor Gene Polymorphisms

scholarly journals Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals

2011 ◽  
Vol 13 (1) ◽  
pp. 133-140 ◽  
Author(s):  
Nancy Martínez-Rodríguez ◽  
Carlos Posadas-Romero ◽  
Guillermo Cardoso ◽  
José Manuel Pérez-Rodríguez ◽  
Nonanzit Pérez-Hernández ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Gene Polymorphisms ◽  
Complex Disease ◽  
Receptor Gene ◽  
Renin Angiotensin System ◽  
Similar Distribution ◽  
Increased Risk ◽  
Receptor Gene Polymorphisms ◽  
Genetic And Environmental Factors

Introduction: Hypertension is a complex disease in which a significant interaction between genetic and environmental factors takes place. The renin–angiotensin system plays an important role regulating blood pressure to maintain homeostasis and vascular tone. In the present work, the role of angiotensin II type 1-receptor (AGTR1) gene polymorphisms as susceptibility markers for hypertension was evaluated. Materials and methods: Five polymorphisms in the AGTR1 gene were genotyped by 5′ exonuclease TaqMan genotyping assays in 239 hypertensive and 371 non-hypertensive individuals. Results: A similar distribution of rs275651, rs275652, rs275653, and rs5183 polymorphisms was observed in both studied groups. Different distribution of rs5182 genotypes was observed between the studied groups ( p = 0.016). According to the co-dominant model, individuals with rs5182 CC genotype have a 1.83-fold increased risk of developing hypertension ( p = 0.009). Polymorphisms were distributed in two blocks: block 1 included the rs275651, rs275652, and rs275653 polymorphisms, whereas block 2 included the rs5183 and rs5182 polymorphisms. Individuals with hypertension showed increased frequency of ‘ CA’ haplotype of block 2 when compared to non-hypertensive individuals ( p = 0.015, odds ratio = 1.33). Conclusion: The results suggest that the rs5182 gene polymorphism could be involved in the risk of developing hypertension in Mexican individuals.

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