Pathway Analysis of a Genome-Wide Association Study of Ileal Crohn's Disease

2012 ◽  
Vol 31 (10) ◽  
pp. 1549-1554 ◽  
Author(s):  
Young Ho Lee ◽  
Gwan Gyu Song
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Association Study ◽  
Pathway Analysis ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Identification of Risk Loci for Crohn’s Disease Phenotypes Using a Genome-Wide Association Study

2015 ◽  
Vol 148 (4) ◽  
pp. 794-805 ◽  
Author(s):  
Arnald Alonso ◽  
Eugeni Domènech ◽  
Antonio Julià ◽  
Julián Panés ◽  
Valle García-Sánchez ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Disease Phenotypes ◽  
Genome Wide ◽  
A Genome

A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn's Disease in a Japanese Population

2013 ◽  
Vol 144 (4) ◽  
pp. 781-788 ◽  
Author(s):  
Keiko Yamazaki ◽  
Junji Umeno ◽  
Atsushi Takahashi ◽  
Atsushi Hirano ◽  
Todd Andrew Johnson ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Association Study ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

2017 ◽  
Vol 49 (2) ◽  
pp. 262-268 ◽  
Author(s):  
James C Lee ◽  
◽  
Daniele Biasci ◽  
Rebecca Roberts ◽  
Richard B Gearry ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Genetic Contributions

scholarly journals Integrative pathway analysis of a genome-wide association study of V̇o2max response to exercise training

2013 ◽  
Vol 115 (9) ◽  
pp. 1343-1359 ◽  
Author(s):  
Sujoy Ghosh ◽  
Juan C. Vivar ◽  
Mark A. Sarzynski ◽  
Yun Ju Sung ◽  
James A. Timmons ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Exercise Training ◽  
Association Study ◽  
Pathway Analysis ◽  
Genome Wide Association Study ◽  
Gene Set Enrichment Analysis ◽  
Genome Wide Association ◽  
Fatty Acid Transport ◽  
Genome Wide ◽  
A Genome

We previously reported the findings from a genome-wide association study of the response of maximal oxygen uptake (V̇o2max) to an exercise program. Here we follow up on these results to generate hypotheses on genes, pathways, and systems involved in the ability to respond to exercise training. A systems biology approach can help us better establish a comprehensive physiological description of what underlies V̇o2maxtrainability. The primary material for this exploration was the individual single-nucleotide polymorphism (SNP), SNP-gene mapping, and statistical significance levels. We aimed to generate novel hypotheses through analyses that go beyond statistical association of single-locus markers. This was accomplished through three complementary approaches: 1) building de novo evidence of gene candidacy through informatics-driven literature mining; 2) aggregating evidence from statistical associations to link variant enrichment in biological pathways to V̇o2max trainability; and 3) predicting possible consequences of variants residing in the pathways of interest. We started with candidate gene prioritization followed by pathway analysis focused on overrepresentation analysis and gene set enrichment analysis. Subsequently, leads were followed using in silico analysis of predicted SNP functions. Pathways related to cellular energetics (pantothenate and CoA biosynthesis; PPAR signaling) and immune functions (complement and coagulation cascades) had the highest levels of SNP burden. In particular, long-chain fatty acid transport and fatty acid oxidation genes and sequence variants were found to influence differences in V̇o2max trainability. Together, these methods allow for the hypothesis-driven ranking and prioritization of genes and pathways for future experimental testing and validation.

Genome-wide Association Study Signal at the 12q12 Locus for Crohn’s Disease May Represent Associations with the MUC19 Gene

2013 ◽  
Vol 19 (6) ◽  
pp. 1254-1259 ◽  
Author(s):  
Vijay Kumar ◽  
David R. Mack ◽  
Valerie Marcil ◽  
David Israel ◽  
Alfreda Krupoves ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

Pathway analysis of a genome-wide association study in schizophrenia

Gene ◽  
2013 ◽  
Vol 525 (1) ◽  
pp. 107-115 ◽  
Author(s):  
Young Ho Lee ◽  
Jae-Hoon Kim ◽  
Gwan Gyu Song
Keyword(s):  
Association Study ◽  
Pathway Analysis ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome
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