Endothelial Nitric Oxide Synthase Gene Polymorphisms (G894T, 4b/a and T-786C) and Preeclampsia: Meta-Analysis of 18 Case–Control Studies

2012 ◽  
Vol 31 (6) ◽  
pp. 1136-1145 ◽  
Author(s):  
Haiying Chen ◽  
Ge Zhao ◽  
Manni Sun ◽  
He Wang ◽  
Jing Liu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Endothelial nitric oxide synthase gene polymorphisms and risk of diabetic nephropathy: a systematic review and meta-analysis

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Bruno Schmidt Dellamea ◽  
Lana Catani Ferreira Pinto ◽  
Cristiane Bauermann Leitão ◽  
Katia Gonçalves Santos ◽  
Luis Henrique Santos Canani
Keyword(s):  
Nitric Oxide ◽  
Systematic Review ◽  
Diabetic Nephropathy ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052097923
Author(s):  
Xiru Xu ◽  
Woruo Ye ◽  
Hanqing Chen ◽  
Ming Liu ◽  
Weimin Jiang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Essential Hypertension ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Mixed Population ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Increased Susceptibility

Objective We conducted meta-analysis of relevant case-control trials to determine the association between endothelial nitric oxide synthase (eNOS) intron 4a/b gene polymorphisms and hypertension susceptibility. Methods We searched the PubMed, Cochrane, and Embase databases using relevant keywords and reviewed pertinent literature sources. All articles published up to July 2019 were considered for inclusion. Based on the qualified studies, we performed a meta-analysis of the associations between eNOS intron 4a/b polymorphisms and the risk of hypertension. Results Fourteen studies were included in this meta-analysis, including 3344 cases and 3377 controls. The eNOS intron 4a/b locus was significantly associated with increased susceptibility to hypertension (including essential hypertension) in the overall population, according to dominant, allelic, homozygote, heterozygote, and regressive models, in the mixed population according to the regressive model, and in Caucasians according to the dominant, allelic, heterozygote, and regressive models. The eNOS intron 4a/b locus was also significantly associated with increased susceptibility to essential hypertension in the mixed population according to the heterozygote model. Conclusion eNOS intron 4a/b gene polymorphisms increase susceptibility to hypertension, including essential hypertension.

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