High Prevalence of Skin Reactions Among Pediatric Patients with Type 1 Diabetes Using New Technologies: The Alarming Role of Colophonium

2020 ◽  
Vol 22 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Fortunato Lombardo ◽  
Stefano Passanisi ◽  
Lucia Caminiti ◽  
Andrea Barbalace ◽  
Alessandra Marino ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pediatric Patients ◽  
New Technologies ◽  
Skin Reactions ◽  
High Prevalence

The role of myokines in the development of insulin resistance in children, with type 1 diabetes mellitus

2021 ◽  
pp. 19-26
Author(s):  
O. Ye. Pashkova ◽  
N. I. Chudova ◽  
O. S. Litvinenko
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Muscle Strength ◽  
Blood Serum ◽  
Muscle Mass ◽  
Pediatric Patients ◽  
Control Group

The aim — to study the role of myokines in the development of insulin resistance in children with type 1 diabetes mellitus.Materials and methods. Observations involved 68 children with type 1 diabetes mellitus (DM 1), with the mean age 11 to 17 years. Depending on the glycemic controllevel, patients were divided into 3 research groups. The control group consisted of 20 relatively healthy children. Muscle mass, the skeletal muscles index, fat mass and the percentage of fat in the bodywere determined in all patients. The Lovett’s test was used to assess the loss of muscle strength; evaluation of insulin resistance was made based onthe triglyceride­glucose index (TYG). Levels of myostatin, irisin, interleukins ­6 and ­13were measured in blood serum.Results and discussion. It has been established that with deterioration in the level of glycemic controlin DM 1 children, the component redistribution of body composition took place with an increased fat mass proportionand decreased muscle mass. This resulted in the reduced insulin-mediatedabsorption of glucose, that was confirmed by the significant increase in TYG level compared to control group. The analysis of cytokines in the blood serum showed a significant increase in the level of myostatin and interleukin­6 compared with the control group and the tendency to increased levels of the interleukins ­13 and the level of irisin in the blood serum in pediatric patients with DM 1. The increased levels of myostatin in DM 1childrenassociated with an increase in the triglycerides content (r = 0.44, p < 0.05) and raised TYG index (r = 0.33, p < 0.05), testifying theclose correlation between the high myostatin levels and the development of insulin resistance.Conclusions. In children with diabetes mellitus, the reduction of muscle strength and muscle mass take place with a deterioration in the state of glycemic control, accompanying by the development of insulin resistance. The violation of myokines synthesis,along with the chronic hyperglycemia and diabetic myopathy, plays the leading role in the formation of insulin resistance in pediatric patients with DM 1. It is manifested by the increased production of myostatin and interleukin­6 in the absence of activation of irisin and interleukin­13synthesis.

scholarly journals Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression

2021 ◽  
Vol 22 (22) ◽  
pp. 12135
Author(s):  
Katarzyna Kurianowicz ◽  
Maria Klatka ◽  
Agnieszka Polak ◽  
Anna Hymos ◽  
Dominika Bębnowska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cd8 T Cells ◽  
Pancreatic Beta Cells ◽  
Pediatric Patients ◽  
Early Stage ◽  
Newly Diagnosed ◽  
The Relationship ◽  
B And T Lymphocytes

Type 1 diabetes (DM1) is classified as an autoimmune disease. An uncontrolled response of B and T lymphocytes to the body’s own tissues develops in the absence of immune tolerance. The main aim of the study was to evaluate the effect of the duration of type 1 diabetes in children on the expression of TLR receptors and the relationship with the parameters of glycemic control in patients. As a result, we showed significant differences in the level of TLR2, TLR4 and TLR9 expression in patients with DM1 in the early stage of the disease and treated chronically compared to the healthy group. Additionally, in this study, we found that the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells are different for newly diagnosed DM1 individuals, patients receiving chronic treatment and for healthy controls, indicating an important role of these cells in killing pancreatic beta cells. Moreover, higher levels of IL-10 in patients with newly diagnosed DM1 have also been found, confirming the reports found in the literature.

scholarly journals High Frequency of Dermatological Complications in Children and Adolescents with Type 1 Diabetes: A Web-Based Survey

2020 ◽  
pp. 193229682094707
Author(s):  
Fortunato Lombardo ◽  
Stefano Passanisi ◽  
Davide Tinti ◽  
Maria Francesca Messina ◽  
Giuseppina Salzano ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
High Frequency ◽  
Online Survey ◽  
Pediatric Patients ◽  
Glucose Monitoring ◽  
Glucose Sensors ◽  
Skin Reactions ◽  
Web Based

Introduction: Despite advances in the management of type 1 diabetes (T1D), there is an increasing incidence of skin reactions related to diabetes devices such as patch pumps and glucose sensors. Aim of the present study was to assess the prevalence of dermatological complications in pediatric patients with T1D using technological devices. Methods: Online survey regarding skin reactions related to the use of patch pumps and/or glucose sensors was administered to families of children and adolescents (0-17 years) with T1D. Data were collected on demographic characteristics, duration of diabetes, and clinical features of dermatological complications if present. Results: Our study population consisted of 139 patients (female 51.8%) aged 11.1 ± 3.3 years. More than half (51.1%) experienced skin reactions due to patch pumps or glucose sensors. Dermatological complications were mainly caused by continuous glucose monitoring (56.3% of total). Timing of appearance of dermatological reactions varied from a few days to several months after the introduction of the device. The application of hypoallergenic barrier bandages was the most frequently adopted measure to solve the issue. Conclusions: Our study confirmed high frequency of dermatological complications among pediatric patients with type 1 diabetes. Well-designed studies are awaited to provide clear recommendations to minimize the burden of skin issues related to technological devices.

The Role of Secrecy and Disclosure in Type 1 Diabetes Adherence and Glycemic Control

2013 ◽  
Author(s):  
P. Osborn ◽  
C. A. Berg ◽  
A. E. Hughes ◽  
P. Pham ◽  
D. J. Wiebe
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control

Arginine metabolism and gut microbiota changes in pediatric patients with type 1 diabetes

2020 ◽  
Author(s):  
Elena Aghajanova ◽  
Arthur Melkonyan ◽  
Nina Alchujyan ◽  
Bayburdyan Gayane ◽  
Margarita Hovhannisyan ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Pediatric Patients ◽  
Arginine Metabolism
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