Closed-Loop Insulin Delivery for Adults with Type 1 Diabetes Undertaking High-Intensity Interval Exercise Versus Moderate-Intensity Exercise: A Randomized, Crossover Study

2017 ◽  
Vol 19 (6) ◽  
pp. 340-348 ◽  
Author(s):  
Dilshani C. Jayawardene ◽  
Sybil A. McAuley ◽  
Jodie C. Horsburgh ◽  
André La Gerche ◽  
Alicia J. Jenkins ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Crossover Study ◽  
High Intensity ◽  
Closed Loop ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Interval Exercise ◽  
High Intensity Interval ◽  
Randomized Crossover Study

scholarly journals Acute high-intensity interval exercise induces greater levels of serum brain-derived neurotrophic factor in obese individuals

2018 ◽  
Vol 243 (14) ◽  
pp. 1153-1160 ◽  
Author(s):  
Alexandra L Rodriguez ◽  
Michael Whitehurst ◽  
Brandon G Fico ◽  
Katelyn M Dodge ◽  
Peter J Ferrandi ◽  
...  
Keyword(s):  
Blood Lactate ◽  
High Intensity ◽  
Normal Weight ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Bdnf Expression ◽  
Interval Exercise ◽  
Obese Population ◽  
Obese Subjects ◽  
High Intensity Interval

Obesity may attenuate the expression of brain-derived neurotrophic factor (BDNF), thereby increasing the risk of cognitive dysfunction. High-intensity interval exercise (HIIE) has been shown to be as or more effective than continuous moderate-intensity exercise (CME) in promoting the expression of BDNF in normal-weight individuals. Therefore, the primary purpose of this study was to examine whether or not acute HIIE could be utilized as a practical model to explore the BDNF response in obese versus normal-weight subjects when compared to acute CME. The potential relationship of exercise-induced BDNF with blood lactate and cortisol was also examined. Twelve male subjects (six obese and six normal-weight) participated in a counterbalanced and caloric equated experiment: HIIE (30 min, 4 intervals of 4 min at 80%–90% of VO2max with 3 min of active recovery at 50–60% VO2max) and CME (38 min at 50%–60% VO2max). Blood samples were collected prior to, immediately following exercise, and 1 h into recovery for measurements of serum BDNF, blood lactate, and plasma cortisol. Our results showed that the BDNF response to acute HIIE was greater than CME in obese subjects when compared to normal-weight subjects. Similarly, although acute HIIE induced greater blood lactate and plasma cortisol levels than CME, obese subjects produced less blood lactate, but no difference in cortisol than normal-weight subjects. These findings suggest that acute HIIE may be a more effective protocol to upregulate BDNF expression in an obese population, independent of increased lactate and cortisol levels. Impact statement High-intensity interval exercise (HIIE) has been shown to be a time-efficient exercise strategy that provides similar or superior physiological benefits as traditional continuous moderate-intensity exercise (CME). Our previous study demonstrated an equivalent elevation on the BDNF response in both obese and normal-weight individuals following 30 min of acute CME. To discover a time-efficient exercise strategy to improve brain health in an obese population, the present study found that obese individuals elicit a greater level of BDNF following acute HIIE versus CME than normal-weight individuals. These findings indicate that acute HIIE may be an effective strategy to upregulate BDNF expression in obese individuals.

scholarly journals What Doesn't Kill you Makes you Fitter: A Systematic Review of High-Intensity Interval Exercise for Patients with Cardiovascular and Metabolic Diseases

2015 ◽  
Vol 9 ◽  
pp. CMC.S26230 ◽  
Author(s):  
Itamar Levinger ◽  
Christopher S. Shaw ◽  
Nigel K. Stepto ◽  
Samantha Cassar ◽  
Andrew J. McAinch ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Intensity ◽  
Metabolic Diseases ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Peak Power Output ◽  
Moderate Intensity Exercise ◽  
Interval Exercise ◽  
Cardiometabolic Diseases ◽  
High Intensity Interval

High-intensity interval exercise (HIIE) has gained popularity in recent years for patients with cardiovascular and metabolic diseases. Despite potential benefits, concerns remain about the safety of the acute response (during and/or within 24 hours postexercise) to a single session of HIIE for these cohorts. Therefore, the aim of this study was to perform a systematic review to evaluate the safety of acute HIIE for people with cardiometabolic diseases. Electronic databases were searched for studies published prior to January 2015, which reported the acute responses of patients with cardiometabolic diseases to HIIE (≥80% peak power output or ≥85% peak aerobic power, VO2peak). Eleven studies met the inclusion criteria (n = 156; clinically stable, aged 27-66 years), with 13 adverse responses reported (~8% of individuals). The rate of adverse responses is somewhat higher compared to the previously reported risk during moderate-intensity exercise. Caution must be taken when prescribing HIIE to patients with cardiometabolic disease. Patients who wish to perform HIIE should be clinically stable, have had recent exposure to at least regular moderate-intensity exercise, and have appropriate supervision and monitoring during and after the exercise session.

Plasma pentraxin 3 and glucose kinetics following acute high-intensity interval exercise versus continuous moderate-intensity exercise in healthy men

2018 ◽  
Vol 43 (12) ◽  
pp. 1233-1238 ◽  
Author(s):  
Aaron L. Slusher ◽  
Michael Whitehurst ◽  
Arun Maharaj ◽  
Katelyn M. Dodge ◽  
Brandon G. Fico ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
High Intensity ◽  
Repeated Measures ◽  
Time Effect ◽  
Moderate Intensity ◽  
Pentraxin 3 ◽  
Moderate Intensity Exercise ◽  
Glucose Response ◽  
Interval Exercise ◽  
High Intensity Interval

Pentraxin 3 (PTX3) is mainly synthesized and released by neutrophils to help regulate innate immunity. While plasma PTX3 concentrations are associated with improved glucose metabolism and overall metabolic health, there is evidence that significant elevations in plasma glucose downregulate circulating levels of PTX3. To examine whether this relationship would be altered in response to exercise, this study investigated the kinetics of the plasma glucose and PTX3 responses following high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CMIE). It was hypothesized that the increased concentrations of plasma glucose following HIIE compared with CMIE would be associated with an attenuated plasma PTX3 response. Eight healthy male subjects participated in both HIIE and CMIE protocols administered as a randomized, counterbalanced design. Linear mixed models for repeated measures revealed that the overall plasma glucose response was greater following HIIE compared with CMIE (protocol × time effect: p = 0.037). Although the plasma PTX3 response was higher only at 19 min into HIIE compared with CMIE (protocol × time effect: p = 0.013), no relationships were observed between plasma glucose and PTX3 either at baseline or in response to both exercise protocols, as indicated by the area under the curve “with respect to increase” analysis. Our results indicate that exercise-mediated plasma PTX3 concentrations are independent of the plasma glucose response. In addition, the present study suggests that the neutrophil-mediated innate immune response, as indicated by plasma PTX3 response, may be activated earlier during HIIE compared with CMIE.

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