Decreased Glycemic Difference Between Diabetes and Nondiabetes in the Elderly Leads to the Reduced Diagnostic Accuracy of Hemoglobin A1c for Diabetes Screening in an Aged Chinese Population

2016 ◽  
Vol 18 (4) ◽  
pp. 226-232 ◽  
Author(s):  
Xiantong Zou ◽  
Yufeng Li ◽  
Xiaoling Cai ◽  
Simin Zhang ◽  
Xiuying Zhang ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Chinese Population ◽  
Hemoglobin A1c ◽  
The Elderly ◽  
Diabetes Screening

The Peguero-Lo Presti criteria has the highest diagnostic accuracy for the diagnosis of left ventricular hypertrophy in the elderly

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C.A.M Tavares ◽  
N Samesima ◽  
L.A Hajjar ◽  
L.C Godoy ◽  
E.M.P Hirano ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Diagnostic Accuracy ◽  
Ventricular Hypertrophy ◽  
The Elderly ◽  
Left Ventricular ◽  
Accuracy Score ◽  
Increased Sensitivity ◽  
Low Sensitivity ◽  
Ecg Criteria ◽  
Improved Accuracy

Abstract Background Left Ventricular Hypertrophy (LVH) is an independent predictor of mortality and cardiovascular morbidity and the 12-lead ECG is recommended as a universal screening for patients with hypertension. However, the ECG has low sensitivity and there is limited data in patients 70 years or older. The recently published Peguero-Lo Presti (PLP) criteria had improved accuracy compared with other ECG criteria but with very few patients with age ≥70 years included. Purpose To compare the accuracy of the PLP criteria versus the traditional ECG criteria for detecting LVH in patients ≥70 years. Methods Retrospective single-center study. Patients were included if they were 70 years or older and underwent an ECG and echocardiogram (gold standard) less than 180 days apart from jan/2017 to mar/2018. Patients with left or right bundle branch block, non-sinus rhythm or ventricular paced rhythm were excluded. All tracings were independently reviewed by two cardiologists, blinded to the echocardiogram. The PLP criteria was compared against Cornell voltage (CV), Sokolow-Lyon voltage (SL), and Romhilt-Estes 4 and 5 (RE) criteria. LVH was defined as a left ventricular mass index >115 g/m2 in males and >95 g/m2 in females, according to the echocardiogram. McNemar's test, F1 score, and the area under the Receiver Operating Characteristic curves (AUC) were used to compare the diagnostic performance of the tests Results A total of 592 patients were included (mean age 77.5 years, SD: 5.9; 50.8% were women). The PLP criteria had increased sensitivity compared with both the SL and CV criteria (p<0.0001 for both comparisons) and RE5 (p=0.042). PLP also had better specificity than the RE4 criteria (p<0.0001) and the highest F1 accuracy score (Table 1). The AUC of the PLP was significantly higher than the AUC of the CV and RE criteria (0.70 vs 0.66 vs 0.64, respectively, p<0.05) and numerically higher than the SL criteria (AUC=0.67, p=0.311, Figure 1). Conclusion Compared to the traditional ECG criteria for LVH, the PLP criteria had the highest diagnostic accuracy in elderly patients. Figure 1. AUC of the ECG criteira Funding Acknowledgement Type of funding source: None

scholarly journals Multidimensional Health Groups and Healthcare Utilization Among Elderly Chinese: Based on the 2014 CLHLS Dataset

2019 ◽  
Vol 16 (20) ◽  
pp. 3884 ◽  
Author(s):  
Linglong Ye ◽  
Jiecheng Luo ◽  
Ben-Chang Shia ◽  
Ya Fang
Keyword(s):  
Healthcare Utilization ◽  
Chinese Population ◽  
Demographic Factors ◽  
The Elderly ◽  
Severe Disability ◽  
Ageing Population ◽  
Elderly Chinese ◽  
Socio Demographic Factors ◽  
Multidimensional Health ◽  
High Comorbidity

Based on multidimensional health, we aimed to identify health groups among the elderly Chinese population, and examine its relationship with socio-demographic factors on healthcare utilization. Chinese Longitudinal Healthy Longevity Survey in 2014 was adopted. For 2981 participants aged ≥65 years, without missing any health indicators, latent class analysis was adopted to identify health groups. For 1974 participants with complete information, the two-part model was used to assess how health groups and socio-demographic characteristics influence the outpatient and inpatient expenditure. Four health groups were identified and labeled as “Lacking Socialization” (10.4%), “High Comorbidity” (16.7%), “Severe Disability” (7.8%), and “Relative Health” (65.1%). Compared with the relative health group, the lacking socialization group cost higher inpatient expenditure (p = 0.02). Those in the high comorbidity and severe disability groups were more likely to use healthcare services and cost higher outpatient expenditure (p < 0.01 for all). The effects of socio-demographic factors were also discussed. The findings enhanced our understanding of the heterogeneity of multidimensional health status and complex healthcare demands in the elderly Chinese population. Moreover, it is valuable for improving the allocation of healthcare resource targeted for different groups of the ageing population.

Diagnostic accuracy of the triglyceride-glucose index for gestational diabetes screening: a practical approach

2020 ◽  
Vol 36 (12) ◽  
pp. 1112-1115
Author(s):  
Adriana Sánchez-García ◽  
René Rodríguez-Gutiérrez ◽  
Donato Saldívar-Rodríguez ◽  
Abel Guzmán-López ◽  
Carolina Castillo-Castro ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Diagnostic Accuracy ◽  
Practical Approach ◽  
Diabetes Screening ◽  
Triglyceride Glucose Index

scholarly journals DIAGNOSTIC ACCURACY OF A NOVEL CUFFLESS BLOOD PRESSURE MONITOR FOR ATRIAL FIBRILLATION SCREENING IN THE ELDERLY

2019 ◽  
Vol 37 ◽  
pp. e301
Author(s):  
K. Kyriakoulis ◽  
A. Kollias ◽  
I. Anagnostopoulos ◽  
A. Gravvani ◽  
P. Kalogeropoulos ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Diagnostic Accuracy ◽  
The Elderly ◽  
Blood Pressure Monitor ◽  
Pressure Monitor ◽  
Cuffless Blood Pressure

scholarly journals Detecting delirium superimposed on dementia: diagnostic accuracy of a simple combined arousal and attention testing procedure

2017 ◽  
Vol 29 (10) ◽  
pp. 1585-1593 ◽  
Author(s):  
Sarah J. Richardson ◽  
Daniel H. J. Davis ◽  
Giuseppe Bellelli ◽  
Wolfgang Hasemann ◽  
David Meagher ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Medical Records ◽  
Clinical Utility ◽  
The Elderly ◽  
Testing Procedure ◽  
Cognitive Tests ◽  
Attention Task ◽  
High Diagnostic Accuracy ◽  
Eye Opening ◽  
Delirium Superimposed On Dementia

ABSTRACTBackground:Detecting delirium superimposed on dementia (DSD) can be challenging because assessment partly relies on cognitive tests that may be abnormal in both conditions. We hypothesized that a combined arousal and attention testing procedure would accurately detect DSD.Methods:Patients aged ≥70 years were recruited from five hospitals across Europe. Delirium was diagnosed by physicians using DSM-5 criteria using information from nurses, carers, and medical records. Dementia was ascertained by the Informant Questionnaire on Cognitive Decline in the Elderly. Arousal was measured using the Observational Scale of Level of Arousal (OSLA), which assesses eye opening, eye contact, posture, movement, and communication. Attention was measured by participants signaling each time an “A” was heard when “S-A-V-E-A-H-A-A-R-T” was read out.Results:The sample included 114 persons (mean age 82 years (SD 7); 54% women). Dementia alone was present in 25% (n = 28), delirium alone in 18% (n = 21), DSD in 27% (n = 31), and neither in 30% (n = 34). Arousal and attention was assessed in n = 109 (96%). Using OSLA, 83% participants were correctly identified as having delirium (sensitivity 85%, specificity 82%, AUROC 0.92). The attention task correctly classified 76% of participants with delirium (sensitivity 90%, specificity 64%, AUROC 0.80). Combining scores correctly classified 91% of participants with delirium (sensitivity 84%, specificity 92%, AUROC 0.94). Diagnostic accuracy remained high in the subgroup with dementia (93% correctly classified, sensitivity 94%, specificity 92%, AUROC 0.98).Conclusions:This combined arousal–attention assessment to detect DSD was brief yet had high diagnostic accuracy. Such an approach could have clinical utility for diagnosing DSD.

scholarly journals Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

2018 ◽  
Vol 115 (8) ◽  
pp. 1697-1706 ◽  
Author(s):  
Xiaopu Zhou ◽  
Yu Chen ◽  
Kin Y. Mok ◽  
Qianhua Zhao ◽  
Keliang Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Immune System ◽  
Chinese Population ◽  
Disease Onset ◽  
The Elderly ◽  
Common Variants ◽  
Altered Expression ◽  
Risk Variants ◽  
Regulatory Effects

Alzheimer’s disease (AD) is a leading cause of mortality among the elderly. We performed a whole-genome sequencing study of AD in the Chinese population. In addition to the variants identified in or around the APOE locus (sentinel variant rs73052335, P = 1.44 × 10−14), two common variants, GCH1 (rs72713460, P = 4.36 × 10−5) and KCNJ15 (rs928771, P = 3.60 × 10−6), were identified and further verified for their possible risk effects for AD in three small non-Asian AD cohorts. Genotype–phenotype analysis showed that KCNJ15 variant rs928771 affects the onset age of AD, with earlier disease onset in minor allele carriers. In addition, altered expression level of the KCNJ15 transcript can be observed in the blood of AD subjects. Moreover, the risk variants of GCH1 and KCNJ15 are associated with changes in their transcript levels in specific tissues, as well as changes of plasma biomarkers levels in AD subjects. Importantly, network analysis of hippocampus and blood transcriptome datasets suggests that the risk variants in the APOE, GCH1, and KCNJ15 loci might exert their functions through their regulatory effects on immune-related pathways. Taking these data together, we identified common variants of GCH1 and KCNJ15 in the Chinese population that contribute to AD risk. These variants may exert their functional effects through the immune system.

Metabolite Triplet in Serum Improves the Diagnostic Accuracy of Prediabetes and Diabetes Screening

2020 ◽  
Vol 20 (1) ◽  
pp. 1005-1014
Author(s):  
Lichao Wang ◽  
Yinan Zhang ◽  
Xinyu Liu ◽  
Xinjie Zhao ◽  
Yang Ouyang ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Diabetes Screening

P2-454: A NEW AGE-BASED CUTOFF OF VISUAL RATING SCALES IN MRI: IMPROVING THE DIAGNOSTIC ACCURACY OF AD IN A CHINESE POPULATION

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P893-P894
Author(s):  
Jinzhou Tian ◽  
Mingqing Wei ◽  
Jing Shi ◽  
Jingnian Ni ◽  
Xuekai Zhang ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Chinese Population ◽  
Rating Scales ◽  
New Age ◽  
Visual Rating

scholarly journals French version of the Rating Scale for Aggressive Behaviour in the Elderly (F-RAGE): Psychometric properties and diagnostic accuracy

2013 ◽  
Vol 7 (3) ◽  
pp. 278-285 ◽  
Author(s):  
Barry Adama ◽  
Calvet Benjamin ◽  
Clément Jean-Pierre ◽  
Druet-Cabanac Michel ◽  
Prado-Jean Annie
Keyword(s):  
Diagnostic Accuracy ◽  
Psychometric Properties ◽  
Aggressive Behaviour ◽  
Rating Scale ◽  
Internal Consistency Reliability ◽  
The Elderly ◽  
Clinical Impression ◽  
Validity And Reliability ◽  
French Version ◽  
Clinical Diagnoses

ABSTRACT Aggressive behaviour is the most disturbing and distressing behaviour displayed by elderly people. The prevalence of aggressive behaviour is around 50% among psychogeriatric patients. Objective: This study sought to analyze the psychometric properties and diagnostic accuracy of the French version of the Rating Scale for Aggressive Behaviour in the Elderly (F-RAGE). Methods: The F-RAGE was administered to 79 patients hospitalized in a geriatric psychiatry department. A psychiatrist, who was blind to the subjects' RAGE scores, performed the diagnosis for aggressivity based on global clinical impression. The F-RAGE and MMSE were applied by a trained researcher blind to subjects' clinical diagnoses while the Cohen-Mansfield Agitation Inventory and Neuropsychiatric Inventory were administered by medical and nursing staff. Internal consistency, reliability, cut-off points, sensitivity and specificity for F-RAGE were estimated. Results: F-RAGE showed satisfactory validity and reliability measurements. Regarding reliability, Cronbach's a coefficient was satisfactory with a value of 0.758. For diagnostic accuracy, a cut-off point of 8 points (sensitivity=74.19%; specificity=97.98%) and area under curve of 0.960 were estimated to distinguish between aggressive patients and control subjects. Discussion: F-RAGE showed acceptable psychometric properties, supported by evidence of validity and reliability for its use in the diagnosis of aggressive behaviour in elderly.

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