Association of Hepatic Lipase Gene Polymorphisms with Hypertriglyceridemia and Low High-Density Lipoprotein-Cholesterol Levels Among South Indian Subjects Without Diabetes

2013 ◽  
Vol 15 (6) ◽  
pp. 503-512 ◽  
Author(s):  
Kuppuswamy Ashok Ayyappa ◽  
Saurabh Ghosh ◽  
Viswanathan Mohan ◽  
Venkatesan Radha
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Gene Polymorphisms ◽  
Hepatic Lipase ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipase Gene ◽  
Cholesterol Levels ◽  
South Indian ◽  
Hepatic Lipase Gene

Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults

2008 ◽  
Vol 33 (4) ◽  
pp. 761-768 ◽  
Author(s):  
Kevin C.M. Wood ◽  
Morgan D. Fullerton ◽  
Ahmed El-Sohemy ◽  
Marica Bakovic
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Gene Polymorphisms ◽  
Hepatic Lipase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

The purpose of this study was to assess the individual and interactive effects between hepatic lipase (LIPC; C-514T, G-250A) and apolipoprotein E (APOE) (E2, E3, E4) gene polymorphisms on levels of plasma lipoprotein cholesterol and triglyceride among healthy, young, Canadian adults (n = 440). All subjects with at least one APOE2 allele had significantly lower low-density lipoprotein cholesterol, total cholesterol, and total cholesterol – high-density lipoprotein cholesterol ratio when compared with those with the APOE3 or APOE4 allele. There were significant differences in the LIPC allele and genotype frequencies between Caucasian (n = 207) and Asian (n = 211) individuals, but ethnicity did not contribute to the variations in circulating lipids. In addition, the lowest triglyceride levels (0.87 ± 0.27 mmol·mL–1) were found in all APOE2 individuals carrying LIPC-514-CC and LIPC-250-GG genotypes, whereas the highest triglyceride levels (1.29 ± 0.34 –1.32 ± 0.32 mmol·mL–1) were found in APOE2 individuals carrying the opposite genotypes, LIPC-514TT and LIPC-250AA. These observations, distinct from the anti-atherogenic effects of APOE2 through the lowering of low-density lipoprotein cholesterol and LIPC on high-density lipoprotein cholesterol, suggest that there is an interactive effect between APOE and LIPC genotypes on plasma triglyceride levels. These results provide the basis for further studies on establishing which genotype combinations would be the most protective against hypertriglyceridemia.

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