scholarly journals The Gonadal Hormone Regulates the Plasma Lactate Levels in Type 2 Diabetes Treated With and Without Metformin

2012 ◽  
Vol 14 (6) ◽  
pp. 469-474 ◽  
Author(s):  
Ying Shen ◽  
Fang Liu ◽  
Qing Li ◽  
Junling Tang ◽  
Taishan Zheng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gonadal Hormone ◽  
Plasma Lactate ◽  
Lactate Levels

scholarly journals Type-2-diabetes Alters CSF but not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys

2019 ◽  
Author(s):  
Kylie Kavanagh ◽  
Stephen M. Day ◽  
Morgan C. Pait ◽  
William R. Mortiz ◽  
Christopher B. Newgard ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acids ◽  
Cerebral Metabolism ◽  
Vervet Monkeys ◽  
Plasma Lactate ◽  
Glucose Levels ◽  
Highly Correlated ◽  
Lactate Levels ◽  
The Brain

AbstractEpidemiological studies suggest that individuals with type 2 diabetes (T2D) have a 2-4 fold increased risk for developing Alzheimer’s disease (AD), however the exact mechanisms linking the two disease is unknown. In both conditions, the majority of pathophysiological changes (including glucose and insulin dysregulation, insulin resistance, and AD-related changes in Aβ and tau) occur decades before the onset of clinical symptoms and diagnosis. In this study, we investigated the relationship between metabolic biomarkers associated with T2D and AD-related pathology, including Aβ levels, from cerebrospinal fluid (CSF) and fasting plasma of healthy, prediabetic (PreD), and T2D vervet monkeys (Chlorocebus aethiops sabeus). Consistent with the human disease, T2D monkeys have increased plasma and CSF glucose levels as they transition from normoglycemia to pre-diabetic and diabetic states. Although plasma levels of acylcarnitines and amino acids remained largely unchanged, peripheral hyperglycemia correlated with decreased CSF acylcarnitines and CSF amino acids, including branched chain amino acid (BCAA) concentrations, suggesting profound changes in cerebral metabolism coincident with systemic glucose dysregulation. Moreover, CSF Aβ40 and CSF Aβ42 levels decreased in T2D monkeys, a phenomenon observed in the human course of AD which coincides with increased amyloid deposition within the brain. In agreement with our previous studies in mice, CSF Aβ40 and CSF Aβ42 were highly correlated with CSF glucose levels, suggesting that glucose levels in the brain are associated with changes in Aβ metabolism. Interestingly, CSF Aβ40 and CSF Aβ42 levels were also highly correlated with plasma but not CSF lactate levels, suggesting that plasma lactate might serve as a potential biomarker of disease progression in AD. Moreover, CSF glucose and plasma lactate levels were correlated with CSF amino acid and acylcarnitine levels, demonstrating alterations in cerebral metabolism occurring with the onset of T2D. Together, these data suggest that peripheral metabolic changes associated with the development of T2D produce alterations in brain metabolism that lead to early changes in the amyloid cascade, similar to those observed in pre-symptomatic AD.

scholarly journals Gonadal hormone regulates the expression MATE1 and OCT2 in type 2 diabetes mice

2015 ◽  
Author(s):  
Ligen Ai ◽  
Dandan Zhang ◽  
Wolin Hou ◽  
Junxi Lu ◽  
Junling Tang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gonadal Hormone ◽  
Diabetes Mice

Low plasma lactate concentration as a biomarker of an incompetent brain-pull: A risk factor for weight gain in type 2 diabetes patients

2010 ◽  
Vol 35 (9) ◽  
pp. 1287-1293 ◽  
Author(s):  
Regina van Dyken ◽  
Christian Hubold ◽  
Sonja Meier ◽  
Britta Hitze ◽  
Aja Marxsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Weight Gain ◽  
Lactate Concentration ◽  
Plasma Lactate ◽  
Plasma Lactate Concentration ◽  
Diabetes Patients

scholarly journals PL - 036 Interactive effects of exercise and metformin on lactic metabolism in type 2 diabetes

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Xiaowei Ojanen ◽  
Moritz Schumann ◽  
Shenglong Le ◽  
Yuan Zhang ◽  
Tao Huang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lactic Acidosis ◽  
Serum Lactate ◽  
Metformin Treatment ◽  
Inclusion Criteria ◽  
Test Strips ◽  
Testing Procedures ◽  
Increased Risk ◽  
Lactate Levels

Objective Lactic acidosis is typically caused by an imbalance in lactic metabolism. This may be attributed to several reasons and is usually a result of complex interactions. There may be an increased risk for lactic acidosis in type 2 diabetes mellitus (T2D) patients when metformin treatment and physical exercise are combined since both metformin and exercise acutely affect lactic metabolism. As timing of exercise following metformin ingestion may determine the magnitude of long-term metabolic adaptations, this study aimed to test the acute effects of exercise performed at different times following metformin ingestion on lactic metabolism in T2D patients with a randomized crossover time series study design. Methods Participants were recruited from two clinical health-care centers in China using a two-step screening procedure. First, approximately 2 523 patients with T2D were screened from the local diabetes database and clinical outpatient registration with inclusion criteria being men and women (30–65 years old) diagnosed with T2D no more than 5 years ago and treated with metformin (maximal daily dose of 2000 mg). Out of 100 potential participants who met the inclusion criteria, 56 were interested and invited to a laboratory visit. Finally, 34 patients participated in the study and of those, 26 patients (14 women and 12 men, mean age = 53.8 ± 8.6 years) completed all testing procedures. All patients visited the laboratory on 4 occasions, each separated by at least 48 hours. Initially a control visit was performed and consisted of metformin administration only (Metf) and a maximal incremental cycle ergometer test in the afternoon. Thereafter, all participants performed a high-intensity interval training session (HIIT, 3 minutes at 40% followed by 1 minute of 85% of maximum power output) 30 minutes (EX30), 60 minutes (EX60), and 90 minutes (EX90) post breakfast and metformin administration, respectively, in a randomized order. Serum lactate and glucose concentrations were assessed enzymatically, while insulin was assessed by an electrochemiluminescence immunoassay and superoxide dismutase (SOD) activity was determined by spectrophotometry. Measurements were performed before breakfast as well as both before and immediately after each exercise bout. In addition, capillary blood glucose concentrations were measured immediately after sampling using Omron AS1 glucose test strips (HGM-114) and lactate concentrations were assessed by ARKRAY Lactate Pro 2 test strips throughout each measurement day. Dietary intake was standardized on the evening prior to each laboratory day as well as between 8:00 a.m. and 4:00 p.m. during each testing day. This trial is registered with ChiCTR-IOR-16008469 on 13th of May 2016. Results During all three-exercise sessions, the capillary lactate concentrations were significantly increased to a similar extent. However, sixty minutes following metformin administration, serum lactate levels began to accumulate to the highest level, where 30% of patients showed lactate concentrations above resting values (≥2 mmol·L-1). The increased lactate concentrations were statistically associated with increased glucose when exercise was performed 60 minutes post metformin administration (r=0.384, p=0.048). Furthermore, in EX60 and EX90 lactate concentrations were 19% and 8% higher, respectively, compared to EX30. In addition, we found that after exercise but not before exercise, the lactate level was positively correlated with SOD (EX30 r=0.478 and p=0.012, EX60 r=0.562 and p=0.002, EX90 r=0.562 and p=0.003, respectively). Conclusions We found that the changes of lactate concentrations were related to the timing of exercise post meal and after metformin ingestion. Thus, timing of exercise appears to be an important factor to be considered when prescribing exercise for T2D patients treated with metformin. In the present study, the optimal timing of HIIT exercise was 30 minutes after metformin administration, which was indicated by a minimized fluctuation of both glucose and lactate levels in T2D patients. Our results also suggest that lactic metabolism and oxidative stress could be among the main underlying molecular mechanisms that elucidate the combinational therapy of exercise and metformin treatment on T2D. Since both acute exercise and metformin may induce opposite effects on ATP production and reactive oxygen species formation, it is important to conduct further studies in an attempt to define the “safe time” for exercise after metformin administration.

Relationships between plasma lactate, plasma alanine, genetic variations in lactate transporters and type 2 diabetes in the Japanese population

2020 ◽  
Vol 35 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Issei Higuchi ◽  
Yuki Kimura ◽  
Masaki Kobayashi ◽  
Katsuya Narumi ◽  
Ayako Furugen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Population ◽  
Genetic Variations ◽  
Plasma Lactate

scholarly journals The relationship between metformin therapy and the fasting plasma lactate in type 2 diabetes: The Fremantle Diabetes Study

2001 ◽  
Vol 52 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Timothy M. E. Davis ◽  
Denise Jackson ◽  
Wendy A. Davis ◽  
David G. Bruce ◽  
Paul Chubb
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Lactate ◽  
Metformin Therapy ◽  
Fasting Plasma ◽  
The Relationship

Plasma lactate predicts lower body weight in patients with type 2 diabetes

2004 ◽  
Vol 112 (08) ◽  
Author(s):  
S Meier ◽  
C Hubold ◽  
A Marxen ◽  
U Schweiger ◽  
HL Fehm ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Lower Body ◽  
Plasma Lactate ◽  
Lower Body Weight
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