Reduction in Intrasubject Variability in the Pharmacokinetic Response to Insulin After Subcutaneous Co-Administration with Recombinant Human Hyaluronidase in Healthy Volunteers

Linda Morrow; Douglas B. Muchmore; Elizabeth A. Ludington; Daniel E. Vaughn; Marcus Hompesch

doi:10.1089/dia.2011.0115

Reduction in Intrasubject Variability in the Pharmacokinetic Response to Insulin After Subcutaneous Co-Administration with Recombinant Human Hyaluronidase in Healthy Volunteers

Diabetes Technology & Therapeutics ◽

10.1089/dia.2011.0115 ◽

2011 ◽

Vol 13 (10) ◽

pp. 1039-1045 ◽

Cited By ~ 16

Author(s):

Linda Morrow ◽

Douglas B. Muchmore ◽

Elizabeth A. Ludington ◽

Daniel E. Vaughn ◽

Marcus Hompesch

Keyword(s):

Healthy Volunteers ◽

Intrasubject Variability ◽

Recombinant Human Hyaluronidase

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The INFUSE-Morphine IIB Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneous Morphine in Healthy Volunteers

Journal of Pain and Symptom Management ◽

10.1016/j.jpainsymman.2009.03.010 ◽

2009 ◽

Vol 38 (5) ◽

pp. 673-682 ◽

Cited By ~ 14

Author(s):

Jay R. Thomas ◽

Richard C. Yocum ◽

Michael F. Haller ◽

Jocelyne Flament

Keyword(s):

Healthy Volunteers ◽

Recombinant Human Hyaluronidase

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Inter- and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1990.tb03691.x ◽

1990 ◽

Vol 29 (6) ◽

pp. 703-708 ◽

Cited By ~ 60

Author(s):

OU Petring ◽

H Flachs

Keyword(s):

Gastric Emptying ◽

Healthy Volunteers ◽

Intrasubject Variability ◽

Paracetamol Absorption

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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers

Current Therapeutic Research ◽

10.1016/j.curtheres.2020.100604 ◽

2020 ◽

Vol 93 ◽

pp. 100604

Author(s):

Marie A. Printz ◽

Samuel S. Dychter ◽

Emanuel P. DeNoia ◽

Rena Harrigan ◽

Barry J. Sugarman ◽

...

Keyword(s):

Phase I ◽

Healthy Volunteers ◽

Phase I Study ◽

Pharmacokinetics And Pharmacodynamics ◽

Recombinant Human Hyaluronidase

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Comparison of the tolerability of recombinant human hyaluronidase + normal saline and recombinant human hyaluronidase + lactated ringer's solution administered subcutaneously: A phase IV, double-blind, randomized pilot study in healthy volunteers

Current Therapeutic Research ◽

10.1016/j.curtheres.2009.12.005 ◽

2009 ◽

Vol 70 (6) ◽

pp. 421-438 ◽

Cited By ~ 11

Author(s):

Samuel S. Dychter ◽

David Ebel ◽

Tonya R. Mead ◽

Richard C. Yocum

Keyword(s):

Pilot Study ◽

Healthy Volunteers ◽

Normal Saline ◽

Double Blind ◽

Ringer’S Solution ◽

Lactated Ringer's Solution ◽

Recombinant Human Hyaluronidase ◽

Phase Iv

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Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers

Pulmonary Pharmacology & Therapeutics ◽

10.1016/j.pupt.2015.10.011 ◽

2015 ◽

Vol 35 ◽

pp. 50-59 ◽

Cited By ~ 7

Author(s):

O. Holz ◽

L. Tan ◽

F. Schaumann ◽

M. Müller ◽

D. Scholl ◽

...

Keyword(s):

Inflammatory Response ◽

Healthy Volunteers ◽

Intrasubject Variability ◽

Endotoxin Challenge

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Tolerability and Pharmacokinetic Properties of Ondansetron Administered Subcutaneously With Recombinant Human Hyaluronidase in Minipigs and Healthy Volunteers

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.12.013 ◽

2014 ◽

Vol 36 (2) ◽

pp. 211-224 ◽

Cited By ~ 10

Author(s):

Samuel S. Dychter ◽

Rena Harrigan ◽

Jesse D. Bahn ◽

Marie A. Printz ◽

Barry J. Sugarman ◽

...

Keyword(s):

Healthy Volunteers ◽

Pharmacokinetic Properties ◽

Recombinant Human Hyaluronidase

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Safety, Tolerability and Pharmacokinetics of High‐Volume Subcutaneous Crenezumab, With and Without Recombinant Human Hyaluronidase in Healthy Volunteers

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2385 ◽

2021 ◽

Author(s):

Michael J. Dolton ◽

Aaron Chesterman ◽

Anita Moein ◽

Kaycee M. Sink ◽

Ariel Waitz ◽

...

Keyword(s):

Healthy Volunteers ◽

High Volume ◽

Recombinant Human Hyaluronidase

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Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole differently in duodenal ulcer patients and healthy volunteers

Gastroenterology ◽

10.1016/s0016-5085(01)83223-6 ◽

2001 ◽

Vol 120 (5) ◽

pp. A648-A648

Author(s):

A THOMSON ◽

R LASTIWKA ◽

M KEELAN ◽

S APPELMAN ◽

L ZUK ◽

...

Keyword(s):

Duodenal Ulcer ◽

Helicobacter Pylori ◽

Acid Secretion ◽

Healthy Volunteers ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Helicobacter Pylori Infection

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Stereoselective pharmacokinetics of S-salbutamol after administration of the racemate in healthy volunteers

European Respiratory Journal ◽

10.1034/j.1399-3003.1999.13f04.x ◽

1999 ◽

Vol 13 (6) ◽

pp. 1230 ◽

Cited By ~ 45

Author(s):

B Schmekel ◽

I Rydberg ◽

B Norlander ◽

K.n Sjöswärd ◽

J Ahlner ◽

...

Keyword(s):

Healthy Volunteers ◽

Stereoselective Pharmacokinetics

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P-Wave Configuration in the Signal Averaged Electrocardiogram: Which Filter Technique Differentiates Best Between Patients With Paroxysmal Atrial Fibrillation and Healthy Volunteers?

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)83917-4 ◽

1998 ◽

Vol 31 (2) ◽

pp. 47A

Author(s):

M Hofmann

Keyword(s):

Atrial Fibrillation ◽

Healthy Volunteers ◽

Paroxysmal Atrial Fibrillation ◽

P Wave ◽

Filter Technique

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