scholarly journals Obesity and Coronary Artery Calcium in Diabetes: The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study

2011 ◽  
Vol 13 (10) ◽  
pp. 991-996 ◽  
Author(s):  
Ticiana C. Rodrigues ◽  
Adrienne M. Veyna ◽  
Michelle D. Haarhues ◽  
Gregory L. Kinney ◽  
Marian Rewers ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcification

Progression of Coronary Artery Calcification Is Associated with Clinically Relevant Cognitive Impairment in Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1473-P
Author(s):  
JINGCHUAN GUO ◽  
KAREN NUNLEY ◽  
CATERINA ROSANO ◽  
TREVOR J. ORCHARD
Keyword(s):  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Coronary Artery ◽  
Coronary Artery Calcification

scholarly journals The role of coronary artery calcification testing in incident coronary artery disease risk prediction in type 1 diabetes

Diabetologia ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Jingchuan Guo ◽  
Sebhat A. Erqou ◽  
Rachel G. Miller ◽  
Daniel Edmundowicz ◽  
Trevor J. Orchard ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Risk Prediction ◽  
Coronary Artery Calcification ◽  
Disease Risk ◽  
Coronary Artery Disease Risk ◽  
Artery Disease

Abstract 569: Albuminuria, the HDL Proteome, and Prevalent Coronary Artery Calcium in Type 1 Diabetes

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Baohai Shao ◽  
Leila Zelnick ◽  
Jake Wimberger ◽  
John Brunzell ◽  
Jonathan Himmelfarb ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Renin Angiotensin System ◽  
Cross Sectional Study ◽  
Lipid Lowering ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cvd Risk ◽  
Cross Sectional

Patients with type 1 diabetes (T1D) are at high risk of atherosclerotic cardiovascular disease (CVD). Albuminuria is strongly associated with CVD risk and fully accounts for the excess overall mortality risk in some T1D cohorts. One important contributor might be alterations of the HDL proteome. In the current study, we tested the hypotheses that albuminuria is associated with alterations in the HDL proteome in T1D, and that these alterations are associated with prevalent CVD. We performed a cross-sectional study of 191 Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) participants selected according to levels of urine albumin excretion (67 persistent normoalbuminuria, 64 persistent microalbuminuria, and 60 persistent macroalbuminuria). We used targeted proteomics and isotope dilution tandem-mass spectrometry to quantify the concentration of 47 proteins in HDL. Adjusting for age, sex, DCCT treatment group, duration of diabetes, lipid-lowering medications, renin-angiotensin system inhibitors, smoking, BMI, and HbA1c, and after accounting for multiple comparisons, six proteins in HDL were significantly associated with albuminuria (2 increased and 4 decreased). For example, compared to normoalbuminuria, macroalbuminuria was associated with 57% and 177% higher AMBP ( P =0.0003) and PTGDS ( P =0.0006), respectively, and 28% and 27% lower PON1 ( P =0.002) and PON3 ( P =0.008), respectively. Furthermore, PON1 and PON3 in HDL were strongly and negatively associated with the presence of coronary artery calcium, with odds ratios per 1-SD difference of 0.63 (0.43-0.92, 95% CI, P =0.02) for PON1 and 0.59 (0.40-0.87, 95% CI, P =0.008) for PON3. Our observations indicate that the HDL proteome is remodeled in albuminuric patients with T1D, and that these alterations in HDL’s protein cargo may mediate, in part, the relationship of albuminuria with CVD. Because PON1 and PON3 are anti-atherogenic in hypercholesterolemic mice, our data suggest that low levels of PON1 and PON3 in HDL increase the risk of atherosclerosis in diabetic humans. In future studies, it will be important to determine whether reductions of PON1 and PON3 in HDL predict the risk of future CVD in subjects with T1D.

scholarly journals Skin Fluorescence Correlates Strongly with Coronary Artery Calcification Severity in Type 1 Diabetes

2010 ◽  
Vol 12 (5) ◽  
pp. 339-345 ◽  
Author(s):  
Baqiyyah Conway ◽  
Daniel Edmundowicz ◽  
Nathaniel Matter ◽  
John Maynard ◽  
Trevor Orchard
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Skin Fluorescence

scholarly journals Association of apolipoprotein C3 with insulin resistance and coronary artery calcium in patients with type 1 diabetes

2020 ◽  
Author(s):  
Teresa Buckner ◽  
Baohai Shao ◽  
Robert H. Eckel ◽  
Jay W. Heinecke ◽  
Karin E. Bornfeldt ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Apolipoprotein C3

scholarly journals Total Antioxidant Status and Coronary Artery Calcification in Type 1 Diabetes

Diabetes Care ◽  
2001 ◽  
Vol 24 (9) ◽  
pp. 1608-1613 ◽  
Author(s):  
J. Valabhji ◽  
A. J. McColl ◽  
W. Richmond ◽  
M. Schachter ◽  
M. B. Rubens ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Total Antioxidant

scholarly journals Coronary artery calcium may stabilize following islet cell transplantation in patients with type 1 diabetes

2017 ◽  
Vol 31 (10) ◽  
pp. e13059 ◽  
Author(s):  
Jessica M. Madrigal ◽  
Rebecca S. Monson ◽  
Betul Hatipoglu ◽  
José Oberholzer ◽  
George T. Kondos ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Cell Transplantation ◽  
Coronary Artery Calcium ◽  
Islet Cell ◽  
Islet Cell Transplantation

scholarly journals Vitamin D Deficiency and Coronary Artery Calcification in Subjects With Type 1 Diabetes

Diabetes Care ◽  
2010 ◽  
Vol 34 (2) ◽  
pp. 454-458 ◽  
Author(s):  
K. A. Young ◽  
J. K. Snell-Bergeon ◽  
R. G. Naik ◽  
J. E. Hokanson ◽  
D. Tarullo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Coronary Artery Calcification
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