New Pharmacologic Approaches to Spinal Cord Injury: Opiate Antagonists and Thyrotropin-Releasing Hormone

1985 ◽  
Vol 2 (1) ◽  
pp. 5-8 ◽  
Author(s):  
ALAN I. FADEN
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Cord Injury ◽  
Opiate Antagonists

Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury

2008 ◽  
Vol 25 (5) ◽  
pp. E14 ◽  
Author(s):  
Gregory W. J. Hawryluk ◽  
James Rowland ◽  
Brian K. Kwon ◽  
Michael G. Fehlings
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Trials ◽  
Phase Ii ◽  
Sodium Succinate ◽  
Thyrotropin Releasing Hormone ◽  
Acute Spinal Cord Injury ◽  
Releasing Hormone ◽  
Methylprednisolone Sodium Succinate ◽  
Cord Injury

Over the past 2 decades, advances in understanding the pathophysiology of spinal cord injury (SCI) have stimulated the recent emergence of several therapeutic strategies that are being examined in Phase I/II clinical trials. Ten randomized controlled trials examining methylprednisolone sodium succinate, tirilizad mesylate, monosialotetrahexosylganglioside, thyrotropin releasing hormone, gacyclidine, naloxone, and nimodipine have been completed. Although the primary outcomes in these trials were laregely negative, a secondary analysis of the North American Spinal Cord Injury Study II demonstrated that when administered within 8 hours of injury, methylprednisolone sodium succinate was associated with modest clinical benefits, which need to be weighed against potential complications. Thyrotropin releasing hormone (Phase II trial) and monosialotetrahexosylganglioside (Phase II and III trials) also showed some promise, but we are unaware of plans for future trials with these agents. These studies have, however, yielded many insights into the conduct of clinical trials for SCI. Several current or planned clinical trials are exploring interventions such as early surgical decompression (Surgical Treatment of Acute Spinal Cord Injury Study) and electrical field stimulation, neuroprotective strategies such as riluzole and minocycline, the inactivation of myelin inhibition by blocking Nogo and Rho, and the transplantation of various cellular substrates into the injured cord. Unfortunately, some experimental and poorly characterized SCI therapies are being offered outside a formal investigational structure, which will yield findings of limited scientific value and risk harm to patients with SCI who are understandably desperate for any intervention that might improve their function. Taken together, recent advances suggest that optimism for patients and clinicians alike is justified, as there is real hope that several safe and effective therapies for SCI may become available over the next decade.

Quantification of Thyrotropin-Releasing Hormone Changes and Serotonin Content Changes Following Graded Spinal Cord Injury

1995 ◽  
Vol 59 (3) ◽  
pp. 393-398 ◽  
Author(s):  
Scott Shapiro ◽  
Mike Kubek ◽  
Eric Siemers ◽  
Edward Daly ◽  
Jim Callahan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Thyrotropin Releasing Hormone ◽  
Serotonin Content ◽  
Releasing Hormone ◽  
Cord Injury

scholarly journals Administration of increasing doses of gonadotropin-releasing hormone in men with spinal cord injury to investigate dysfunction of the hypothalamic–pituitary–gonadal axis

Spinal Cord ◽  
2017 ◽  
Vol 56 (3) ◽  
pp. 247-258 ◽  
Author(s):  
William A. Bauman ◽  
Michael F. La Fountaine ◽  
Christopher M. Cirnigliaro ◽  
Steven C. Kirshblum ◽  
Ann M. Spungen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Cord Injury

Microglia, Corticotropin-Releasing Hormone, and Spinal Cord Injury

2010 ◽  
Vol 74 (4-5) ◽  
pp. 388-389 ◽  
Author(s):  
Leonardo C. Welling ◽  
Eberval G. Figueiredo
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Cord Injury
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