Sensory Evoked Responses in Head Injury

1985 ◽  
Vol 2 (3) ◽  
pp. 187-206 ◽  
Author(s):  
JUDY R. MACKEY-HARGADINE ◽  
JAMES W. HALL
Keyword(s):  
Head Injury ◽  
Evoked Responses ◽  
Sensory Evoked

scholarly journals Clinical Validation of the Champagne Algorithm for Evoked Response Source Localization in Magnetoencephalography

2021 ◽  
Author(s):  
Abhishek S. Bhutada ◽  
Chang Cai ◽  
Danielle Mizuiri ◽  
Anne Findlay ◽  
Jessie Chen ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Source Localization ◽  
Clinical Population ◽  
Evoked Responses ◽  
Localization Algorithm ◽  
Equivalent Current Dipole ◽  
Current Dipole ◽  
Tumor Patients ◽  
Equivalent Current ◽  
Sensory Evoked

AbstractMagnetoencephalography (MEG) is a robust method for non-invasive functional brain mapping of sensory cortices due to its exceptional spatial and temporal resolution. The clinical standard for MEG source localization of functional landmarks from sensory evoked responses is the equivalent current dipole (ECD) localization algorithm, known to be sensitive to initialization, noise, and manual choice of the number of dipoles. Recently many automated and robust algorithms have been developed, including the Champagne algorithm, an empirical Bayesian algorithm, with powerful abilities for MEG source reconstruction and time course estimation (Wipf et al. 2010; Owen et al. 2012). Here, we evaluate automated Champagne performance in a clinical population of tumor patients where there was minimal failure in localizing sensory evoked responses using the clinical standard, ECD localization algorithm. MEG data of auditory evoked potentials and somatosensory evoked potentials from 21 brain tumor patients were analyzed using Champagne, and these results were compared with equivalent current dipole (ECD) fit. Across both somatosensory and auditory evoked field localization, we found there was a strong agreement between Champagne and ECD localizations in all cases. Given resolution of 8mm voxel size, peak source localizations from Champagne were below 10mm of ECD peak source localization. The Champagne algorithm provides a robust and automated alternative to manual ECD fits for clinical localization of sensory evoked potentials and can contribute to improved clinical MEG data processing workflows.

scholarly journals Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability

2013 ◽  
Vol 33 (7) ◽  
pp. 1115-1126 ◽  
Author(s):  
Basavaraju G Sanganahalli ◽  
Peter Herman ◽  
Fahmeed Hyder ◽  
Sridhar S Kannurpatti
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Types ◽  
Dependent Manner ◽  
Evoked Responses ◽  
Blood Oxygen Level ◽  
Calcium Uniporter ◽  
Sensory Evoked

Local calcium (Ca2 +) changes regulate central nervous system metabolism and communication integrated by subcellular processes including mitochondrial Ca2 + uptake. Mitochondria take up Ca2 + through the calcium uniporter (mCU) aided by cytoplasmic microdomains of high Ca2 +. Known only in vitro, the in vivo impact of mCU activity may reveal Ca2 + -mediated roles of mitochondria in brain signaling and metabolism. From in vitro studies of mitochondrial Ca2 + sequestration and cycling in various cell types of the central nervous system, we evaluated ranges of spontaneous and activity-induced Ca2 + distributions in multiple subcellular compartments in vivo. We hypothesized that inhibiting (or enhancing) mCU activity would attenuate (or augment) cortical neuronal activity as well as activity-induced hemodynamic responses in an overall cytoplasmic and mitochondrial Ca2 + -dependent manner. Spontaneous and sensory-evoked cortical activities were measured by extracellular electrophysiology complemented with dynamic mapping of blood oxygen level dependence and cerebral blood flow. Calcium uniporter activity was inhibited and enhanced pharmacologically, and its impact on the multimodal measures were analyzed in an integrated manner. Ru360, an mCU inhibitor, reduced all stimulus-evoked responses, whereas Kaempferol, an mCU enhancer, augmented all evoked responses. Collectively, the results confirm aforementioned hypotheses and support the Ca2 + uptake-mediated integrative role of in vivo mitochondria on neocortical activity.

scholarly journals Corticotropin-Releasing Factor Acting at the Locus Coeruleus Disrupts Thalamic and Cortical Sensory-Evoked Responses

2012 ◽  
Vol 37 (9) ◽  
pp. 2020-2030 ◽  
Author(s):  
David M Devilbiss ◽  
Barry D Waterhouse ◽  
Craig W Berridge ◽  
Rita Valentino
Keyword(s):  
Locus Coeruleus ◽  
Corticotropin Releasing Factor ◽  
Evoked Responses ◽  
Sensory Evoked

Cervical somato-sensory evoked responses in man

Nature ◽  
1974 ◽  
Vol 252 (5480) ◽  
pp. 230-232 ◽  
Author(s):  
W. B. MATTHEWS ◽  
M. BEAUCHAMP ◽  
D. G. SMALL
Keyword(s):  
Evoked Responses ◽  
Sensory Evoked

Topographical features of the sensory-evoked responses in malformed brains

2000 ◽  
Vol 23 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Yoshiaki Saito ◽  
Kaori Adachi ◽  
Atsuo Nezu ◽  
Kimiko Deguchi ◽  
Seiji Kimura
Keyword(s):  
Evoked Responses ◽  
Sensory Evoked
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