A CpGCluster-Teaching–Learning-Based Optimization for Prediction of CpG Islands in the Human Genome

2018 ◽  
Vol 25 (2) ◽  
pp. 158-169 ◽  
Author(s):  
Cheng-Hong Yang ◽  
Yi-Cheng Chiang ◽  
Li-Yeh Chuang ◽  
Yu-Da Lin
Keyword(s):  
Human Genome ◽  
Cpg Islands ◽  
Teaching Learning Based Optimization ◽  
Teaching Learning

TLBO-FLN: Teaching-Learning Based Optimization of Functional Link Neural Networks for Stock Closing Price Prediction

2020 ◽  
Vol 10 (4) ◽  
pp. 522-532 ◽  
Author(s):  
Sarat Chandra Nayak ◽  
Subhranginee Das ◽  
Mohammad Dilsad Ansari
Keyword(s):  
Neural Networks ◽  
Computational Cost ◽  
Optimization Techniques ◽  
Fine Tuning ◽  
Functional Link ◽  
Price Prediction ◽  
Closing Price ◽  
Teaching Learning Based Optimization ◽  
Artificial Neural ◽  
Teaching Learning

Background and Objective: Stock closing price prediction is enormously complicated. Artificial Neural Networks (ANN) are excellent approximation algorithms applied to this area. Several nature-inspired evolutionary optimization techniques are proposed and used in the literature to search the optimum parameters of ANN based forecasting models. However, most of them need fine-tuning of several control parameters as well as algorithm specific parameters to achieve optimal performance. Improper tuning of such parameters either leads toward additional computational cost or local optima. Methods: Teaching Learning Based Optimization (TLBO) is a newly proposed algorithm which does not necessitate any parameters specific to it. The intrinsic capability of Functional Link Artificial Neural Network (FLANN) to recognize the multifaceted nonlinear relationship present in the historical stock data made it popular and got wide applications in the stock market prediction. This article presents a hybrid model termed as Teaching Learning Based Optimization of Functional Neural Networks (TLBO-FLN) by combining the advantages of both TLBO and FLANN. Results and Conclusion: The model is evaluated by predicting the short, medium, and long-term closing prices of four emerging stock markets. The performance of the TLBO-FLN model is measured through Mean Absolute Percentage of Error (MAPE), Average Relative Variance (ARV), and coefficient of determination (R2); compared with that of few other state-of-the-art models similarly trained and found superior.

Data Mining Technique Applied To DNA Sequencing

2015 ◽  
Vol 2 (7) ◽  
pp. 18
Author(s):  
R. Jamuna
Keyword(s):  
Data Mining ◽  
Dna Methylation ◽  
Markov Chain ◽  
Human Genome ◽  
Transition Probabilities ◽  
Markov Chain Model ◽  
Effective Means ◽  
Cpg Islands ◽  
Chain Model ◽  
The Given

CpG islands (CGIs) play a vital role in genome analysis as genomic markers.  Identification of the CpG pair has contributed not only to the prediction of promoters but also to the understanding of the epigenetic causes of cancer. In the human genome [1] wherever the dinucleotides CG occurs the C nucleotide (cytosine) undergoes chemical modifications. There is a relatively high probability of this modification that mutates C into a T. For biologically important reasons the mutation modification process is suppressed in short stretches of the genome, such as ‘start’ regions. In these regions [2] predominant CpG dinucleotides are found than elsewhere. Such regions are called CpG islands. DNA methylation is an effective means by which gene expression is silenced. In normal cells, DNA methylation functions to prevent the expression of imprinted and inactive X chromosome genes. In cancerous cells, DNA methylation inactivates tumor-suppressor genes, as well as DNA repair genes, can disrupt cell-cycle regulation. The most current methods for identifying CGIs suffered from various limitations and involved a lot of human interventions. This paper gives an easy searching technique with data mining of Markov Chain in genes. Markov chain model has been applied to study the probability of occurrence of C-G pair in the given   gene sequence. Maximum Likelihood estimators for the transition probabilities for each model and analgously for the  model has been developed and log odds ratio that is calculated estimates the presence or absence of CpG is lands in the given gene which brings in many  facts for the cancer detection in human genome.

An MPPT method using hybrid radial movement optimization with teaching-learning based optimization under fluctuating atmospheric conditions

2021 ◽  
pp. 1-10
Author(s):  
Imran Pervez ◽  
Adil Sarwar ◽  
Afroz Alam ◽  
Mohammad ◽  
Ripon K. Chakrabortty ◽  
...  
Keyword(s):  
Maximum Power ◽  
Metaheuristic Algorithms ◽  
Solar Pv ◽  
Maximum Power Point ◽  
Local Optima ◽  
Pv Array ◽  
Radial Movement ◽  
Teaching Learning Based Optimization ◽  
Power Point ◽  
Teaching Learning

Due to its clean and abundant availability, solar energy is popular as a source from which to generate electricity. Solar photovoltaic (PV) technology converts sunlight incident on the solar PV panel or array directly into non-linear DC electricity. However, the non-linear nature of the solar panels’ power needs to be tracked for its efficient utilization. The problem of non-linearity becomes more prominent when the solar PV array is shaded, even leading to high power losses and concentrated heating in some areas (hotspot condition) of the PV array. Bypass diodes used to eliminate the shading effect cause multiple peaks of power on the power versus voltage (P-V) curve and make the tracking problem quite complex. Conventional algorithms to track the optimal power point cannot search the complete P-V curve and often become trapped in local optima. More recently, metaheuristic algorithms have been employed for maximum power point tracking. Being stochastic, these algorithms explore the complete search area, thereby eliminating any chance of becoming trapped stuck in local optima. This paper proposes a hybridized version of two metaheuristic algorithms, Radial Movement Optimization and teaching-learning based optimization (RMOTLBO). The algorithm has been discussed in detail and applied to multiple shading patterns in a solar PV generation system. It successfully tracks the maximum power point (MPP) in a lesser amount of time and lesser fluctuations.

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