scholarly journals Background Adjustment for DNA Microarrays Using a Database of Microarray Experiments

2009 ◽  
Vol 16 (11) ◽  
pp. 1501-1515 ◽  
Author(s):  
Yunxia Sui ◽  
Xiaoyue Zhao ◽  
Terence P. Speed ◽  
Zhijin Wu
Keyword(s):  
Dna Microarrays ◽  
Microarray Experiments ◽  
Background Adjustment

DNA Microarrays in Otolaryngology-Head and Neck Surgery

2002 ◽  
Vol 127 (3) ◽  
pp. 196-204 ◽  
Author(s):  
Mark Eliot Whipple ◽  
Winston Patrick Kuo
Keyword(s):  
Gene Expression ◽  
Head And Neck ◽  
Dna Microarrays ◽  
Clinical Medicine ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Microarray Technology ◽  
Single Experiment ◽  
Substantial Impact ◽  
Microarray Experiments

OBJECTIVES: Our goal was to review the technologies underlying DNA microarrays and to explore their use in otolaryngology-head and neck surgery. STUDY DESIGN: The current literature relating to microarray technology and methodology is reviewed, specifically the use of DNA microarrays to characterize gene expression. Bioinformatics involves computational and statistical methods to extract, organize, and analyze the huge amounts of data produced by microarray experiments. The means by which these techniques are being applied to otolaryngology-head and neck surgery are outlined. RESULTS: Microarray technologies are having a substantial impact on biomedical research, including many areas relevant to otolaryngology-head and neck surgery. CONCLUSIONS: DNA microarrays allow for the simultaneous investigationof thousands of individual genes in a single experiment. In the coming years, the application of these technologies to clinical medicine should allow for unprecedented methods ofdiagnosis and treatment. SIGNIFICANCE: These highly parallel experimental techniques promise to revolutionize gene discovery, disease characterization, and drug development.

scholarly journals Design of Compact, Universal DNA Microarrays for Protein Binding Microarray Experiments

2008 ◽  
Vol 15 (7) ◽  
pp. 655-665 ◽  
Author(s):  
Anthony A. Philippakis ◽  
Aaron M. Qureshi ◽  
Michael F. Berger ◽  
Martha L. Bulyk
Keyword(s):  
Protein Binding ◽  
Dna Microarrays ◽  
Microarray Experiments ◽  
Protein Binding Microarray

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

Can DNA microarrays change diagnostics and therapy of lung cancer?

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
HS Hofmann ◽  
A Simm ◽  
G Hansen ◽  
RJ Scheubel ◽  
RE Silber ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Microarrays ◽  
Diagnostics And Therapy
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