The synthesis of protein-like single molecular nano-particle can be simplified by use fewer but longer monomers, which correspond to several old short monomers. The selection of new long monomer subset is optimized and tested in HP model and other models. Results show 2-3 types new monomer are enough to build stable structure, and long monomers should include integer length of one helix, and with interlaced hydrophobic and polar side-chain, thus can form α-helix like structure.
Feasibility in the inverse protein folding protocol