Oral Mucosa-Derived Induced Pluripotent Stem Cells from Patients with Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

2018 ◽  
Vol 20 (4) ◽  
pp. 215-224
Author(s):  
Marta Trevisan ◽  
Gualtiero Alvisi ◽  
Vanessa Barbaro ◽  
Luisa Barzon ◽  
Paolo Raffa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Oral Mucosa ◽  
Pluripotent Stem Cells ◽  
Ectodermal Dysplasia ◽  
Induced Pluripotent

Generation of human induced pluripotent stem cells from oral mucosa

2010 ◽  
Vol 110 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Keiko Miyoshi ◽  
Daisuke Tsuji ◽  
Keiko Kudoh ◽  
Kazuhito Satomura ◽  
Taro Muto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Oral Mucosa ◽  
Pluripotent Stem Cells ◽  
Induced Pluripotent

scholarly journals Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
Keiko Miyoshi ◽  
Taigo Horiguchi ◽  
Ayako Tanimura ◽  
Hiroko Hagita ◽  
Takafumi Noma
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Oral Mucosa ◽  
Pluripotent Stem Cells ◽  
Hox Genes ◽  
Gene Signature ◽  
Dermal Fibroblasts ◽  
Molecular Characteristics ◽  
Induced Pluripotent ◽  
Pathway Analyses

Oral mucosa is a useful material for regeneration therapy with the advantages of its accessibility and versatility regardless of age and gender. However, little is known about the molecular characteristics of oral mucosa. Here we report the first comparative profiles of the gene signatures of human oral mucosa fibroblasts (hOFs), human dermal fibroblasts (hDFs), and hOF-derived induced pluripotent stem cells (hOF-iPSCs), linking these with biological roles by functional annotation and pathway analyses. As a common feature of fibroblasts, both hOFs and hDFs expressed glycolipid metabolism-related genes at higher levels compared with hOF-iPSCs. Distinct characteristics of hOFs compared with hDFs included a high expression of glycoprotein genes, involved in signaling, extracellular matrix, membrane, and receptor proteins, besides a low expression of HOX genes, the hDFs-markers. The results of the pathway analyses indicated that tissue-reconstructive, proliferative, and signaling pathways are active, whereas senescence-related genes in p53 pathway are inactive in hOFs. Furthermore, more than half of hOF-specific genes were similarly expressed to those of hOF-iPSC genes and might be controlled by WNT signaling. Our findings demonstrated that hOFs have unique cellular characteristics in specificity and plasticity. These data may provide useful insight into application of oral fibroblasts for direct reprograming.

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent

Derivation and Characterization of human Induced Pluripotent Stem Cells

Acta Naturae ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 91-92 ◽  
Author(s):  
M V Shutova ◽  
A N Bogomazova ◽  
M A Lagarkova ◽  
S L Kiselev
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Induced Pluripotent
Sign in / Sign up

Export Citation Format

Share Document