Improving the Efficacy of Cryopreservation of Spermatogonia Stem Cells by Antioxidant Supplements

2016 ◽  
Vol 18 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Fereshte Aliakbari ◽  
Mohamad Ali Sedighi Gilani ◽  
Fardin Amidi ◽  
Maryam Baazm ◽  
Morteza Korouji ◽  
...  
Keyword(s):  
Stem Cells ◽  
Spermatogonia Stem Cells ◽  
Antioxidant Supplements

In Vitro Colonization of Human Spermatogonia Stem Cells: Effect of Patient's Clinical Characteristics and Testicular Histologic Findings

Urology ◽  
2011 ◽  
Vol 78 (5) ◽  
pp. 1075-1081 ◽  
Author(s):  
Mohammad Reza Nowroozi ◽  
Hamed Ahmadi ◽  
Shahram Rafiian ◽  
Tooba Mirzapour ◽  
Mansoureh Movahedin
Keyword(s):  
Stem Cells ◽  
Clinical Characteristics ◽  
Spermatogonia Stem Cells

scholarly journals miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Yani Zhang ◽  
Wenhui Zhang ◽  
Cai Hu ◽  
Yingjie Wang ◽  
Man Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Target Gene ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Reproductive Process ◽  
Competition Mechanism ◽  
Negative Factor ◽  
Spermatogonia Stem Cells ◽  
The Relationship ◽  
Chicken Embryonic Stem Cells

MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary exploration to determine the relationship among miR-302d, lncRNA-341(interacting with miR-302d), and target gene TLE4. The results showed that lncRNA-341 can competitively bind to miR-302d to decrease the targeted binding of miR-302d and TLE4 which promotes the differentiation of chicken SSCs. Moreover, it is suggested that miR-302d may participate in the Wnt signaling pathway through TLE4.

scholarly journals Spermatogonia: stem cells with a great perspective

Reproduction ◽  
2001 ◽  
pp. 825-834 ◽  
Author(s):  
S Meachem ◽  
V von Schonfeldt ◽  
S Schlatt
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Research ◽  
Hormonal Regulation ◽  
Male Contraception ◽  
Comprehensive Overview ◽  
Oncological Patients ◽  
Spermatogonia Stem Cells ◽  
New Research ◽  
Near Future

Interest in spermatogonia has grown in recent years as a result of exciting developments in stem cell research in general and the development of new research tools allowing the isolation, culture and transplantation of these cells. This review focuses on the methodological breakthroughs and highlights the recent findings that have substantially increased understanding of spermatogonial physiology. The article provides a comprehensive overview of the hormonal regulation of spermatogonia and presents several new approaches to the use of spermatogonia in basic science and medicine. In the near future these techniques will allow the development of novel routes for the generation of transgenic lifestock, the treatment of infertility, the targeting for male contraception, and an alternative strategy for fertility preservation of oncological patients.

scholarly journals Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Sara Shaban ◽  
Mostafa Wanees Ahmed El-Husseny ◽  
Abdelrahman Ibrahim Abushouk ◽  
Amr Muhammad Abdo Salem ◽  
Mediana Mamdouh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Culture Media ◽  
Stem Cell Differentiation ◽  
Beneficial Effects ◽  
The Past ◽  
Mitochondrial Dna Damage ◽  
Molecular Effects ◽  
Antioxidant Supplements ◽  
Different Doses

Although physiological levels of reactive oxygen species (ROS) are required to maintain the self-renewal capacity of stem cells, elevated ROS levels can induce chromosomal aberrations, mitochondrial DNA damage, and defective stem cell differentiation. Over the past decade, several studies have shown that antioxidants can not only mitigate oxidative stress and improve stem cell survival but also affect the potency and differentiation of these cells. Further beneficial effects of antioxidants include increasing genomic stability, improving the adhesion of stem cells to culture media, and enabling researchers to manipulate stem cell proliferation by using different doses of antioxidants. These findings can have several clinical implications, such as improving neurogenesis in patients with stroke and neurodegenerative diseases, as well as improving the regeneration of infarcted myocardial tissue and the banking of spermatogonial stem cells. This article reviews the cellular and molecular effects of antioxidant supplementation to cultured or transplanted stem cells and draws up recommendations for further research in this area.

scholarly journals Spermatogonia: stem cells with a great perspective

Reproduction ◽  
2001 ◽  
Vol 121 (6) ◽  
pp. 825-834
Author(s):  
S Meachem
Keyword(s):  
Stem Cells ◽  
Spermatogonia Stem Cells

Differentiation of Spermatogonia Stem Cells into Functional Mature Neurons Characterized with Differential Gene Expression

2016 ◽  
Vol 54 (7) ◽  
pp. 5676-5682 ◽  
Author(s):  
Maryam Nazm Bojnordi ◽  
Hossein Azizi ◽  
Thomas Skutella ◽  
Mansoureh Movahedin ◽  
Fereshteh Pourabdolhossein ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Differential Gene Expression ◽  
Spermatogonia Stem Cells ◽  
Mature Neurons ◽  
Differential Gene
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