Long Noncoding RNA RP11-89K21.1 Interacts with miR-146a/b-5p to Promote Proliferation and Gefitinib Resistance Through Regulating RHPN2 and RhoA/ROCK Pathway in Lung Adenocarcinoma

2021 ◽  
Author(s):  
Huaxin Chen ◽  
Dan Shen ◽  
Feng Zhu ◽  
Qinfang Ou ◽  
Liang Cheng ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Gefitinib Resistance

Long noncoding RNA LINC00520 accelerates lung adenocarcinoma progression via miR-1252-5p/FOXR2 pathway

Human Cell ◽  
2021 ◽  
Vol 34 (2) ◽  
pp. 478-490
Author(s):  
Xinyue Chen ◽  
Huimin Chen ◽  
Miaowen Liu ◽  
Jianping Xiong ◽  
Zhiwang Song
Keyword(s):  
Lung Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Long noncoding RNA CCAT1 acts as an oncogene and promotes chemoresistance in docetaxel-resistant lung adenocarcinoma cells

Oncotarget ◽  
2016 ◽  
Vol 7 (38) ◽  
pp. 62474-62489 ◽  
Author(s):  
Jing Chen ◽  
Kai Zhang ◽  
Haizhu Song ◽  
Rui Wang ◽  
Xiaoyuan Chu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells

Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 correlates with microRNA-125b/microRNA-146a/microRNA-203 and predicts 2-year restenosis risk in coronary heart disease patients

2021 ◽  
Vol 15 (4) ◽  
pp. 257-271
Author(s):  
Yankuo Zhu ◽  
Yinchuan Zhu ◽  
Yingchao Liu ◽  
Yanru Liu ◽  
Xiaoyu Chen
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lung Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Quantitative Coronary Angiography ◽  
Coronary Intervention ◽  
Drug Eluting Stent ◽  
Percutaneous Coronary ◽  
Drug Eluting

Aim: To investigate correlations of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (lnc-MALAT1) and its target microRNAs with clinical features and restenosis risk in coronary heart disease (CHD) patients post drug-eluting stent-percutaneous coronary intervention (DES-PCI). Materials & methods: A total of 274 CHD patients undergoing DES-PCI were enrolled, pre-operative plasma samples were obtained to detect lnc-MALAT1, miR-125b, miR-146a, miR-203 by RT-qPCR; 2-year restenosis was determined by quantitative coronary angiography. Results: Lnc-MALAT1 negatively correlated with miR-125b, miR-146a and miR-203. Furthermore, lnc-MALAT1, miR-125b, miR-146a and miR-203 correlated with diabetes mellitus, hyperuricemia, lesion properties, cholesterol, inflammation and cardiac function indexes. Additionally, lnc-MALAT1 was increased, while miR-125b and miR-146a were decreased in patients with 2-year restenosis than patients without 2-year restenosis; however, miR-203 did not differ. Conclusion: Lnc-MALAT1 and its target miRNAs might help manage restenosis risk in CHD patients post DES-PCI.

scholarly journals Long noncoding RNA TMPO-AS1 promotes lung adenocarcinoma progression and is negatively regulated by miR-383-5p

2020 ◽  
Vol 125 ◽  
pp. 109989 ◽  
Author(s):  
Xiaoqian Mu ◽  
Hongbo Wu ◽  
Jie Liu ◽  
Xiufeng Hu ◽  
Huijuan Wu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis

Oncogene ◽  
2019 ◽  
Vol 38 (16) ◽  
pp. 3061-3076 ◽  
Author(s):  
Xiaolu Ge ◽  
Gui-yuan Li ◽  
Lin Jiang ◽  
Liqing Jia ◽  
Zhezhe Zhang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Knockdown of Long Noncoding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis by Targeting miR-124 in Retinoblastoma

2018 ◽  
Vol 26 (4) ◽  
pp. 581-591 ◽  
Author(s):  
Shujun Liu ◽  
Guigang Yan ◽  
Junfu Zhang ◽  
Lianzhi Yu
Keyword(s):  
Lung Adenocarcinoma ◽  
Cell Viability ◽  
Cell Line ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Migration And Invasion ◽  
Erk Mapk ◽  
Underlying Mechanisms ◽  
Y79 Cells

Evidence suggests that the long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in cancer tissues, and its elevated expression is associated with hyperproliferation. However, the underlying mechanisms regarding the role of MALAT1 in retinoblastoma (RB) remain unclear. This study aimed to explore the functional role of MALAT1 in RB by targeting miR-124. The results showed that the expression of MALAT1 was significantly higher in the Y79 cell line than in the ARPE-19 cell line (p < 0.01). Moreover, MALAT1 silence inhibited cell viability, migration, and invasion and promoted apoptosis in Y79 cells (p < 0.05, p < 0.01, or p < 0.001). miR-124 was upregulated by MALAT1 silence and hence was identified as a target of MALAT1 (p < 0.05 or p < 0.001). In addition, miR-124 suppression inhibited cell apoptosis and remarkably abolished the inhibitory effects of MALAT1 silence on cell viability, migration, and invasion (p < 0.05, p < 0.01, or p < 0.001). In addition, Slug was a target of miR-124 and regulated cell viability, migration, invasion, and apoptosis in Y79 cells (p < 0.05, p < 0.01, or p < 0.001). Further, Slug silence abolished miR-124 suppression-induced inactivation of the ERK/MAPK and Wnt/β-catenin pathways. Taken together, our data highlight the pivotal role of MALAT1 in RB. Moreover, the present study elucidated the MALAT1‐miR-124‐ERK/MAPK and Wnt/β-catenin signaling pathways in RB, which might provide a new approach for the treatment of RB.

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