MiR-146b-5p Regulates the Expression of Long Noncoding RNA MALAT1 and Its Effect on the Invasion and Proliferation of Papillary Thyroid Cancer

2020 ◽  
Author(s):  
You Peng ◽  
Xiang Fang ◽  
Hongli Yao ◽  
Yu Zhang ◽  
Jingjing Shi
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Papillary Thyroid

Long noncoding RNA NEAT1 regulate papillary thyroid cancer progression by modulating miR-129-5p/KLK7expression

2018 ◽  
Vol 233 (10) ◽  
pp. 6638-6648 ◽  
Author(s):  
Hong Zhang ◽  
Yuechang Cai ◽  
Li Zheng ◽  
Zhanlei Zhang ◽  
Xiaofeng Lin ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Papillary Thyroid

scholarly journals Long Noncoding RNA CCAL Promotes Papillary Thyroid Cancer Progression by Activation of NOTCH1 Pathway

2018 ◽  
Vol 26 (9) ◽  
pp. 1383-1390 ◽  
Author(s):  
Ying Ye ◽  
Yanan Song ◽  
Juhua Zhuang ◽  
Saifei He ◽  
Jing Ni ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Thyroid Tumor ◽  
Migration And Invasion ◽  
Papillary Thyroid

Long noncoding RNA CCAL has been reported to promote tumor progression in various human cancers, including hepatocellular carcinoma, osteosarcoma, and colorectal cancer. However, the role of CCAL in papillary thyroid cancer remains largely unknown. In the present study, we found that the expression of CCAL was upregulated in papillary thyroid tumor tissues compared to adjacent normal tissues. Moreover, the expression of CCAL was positively related with papillary thyroid cancer severity and TNM stage and predicated poor prognosis. Besides, we found that knockdown of CCAL significantly inhibited papillary thyroid cancer cell proliferation, migration, and invasion in vitro and reduced tumor growth and metastasis in vivo. We found that knockdown of CCAL dramatically decreased the expression of NOTCH1 and suppressed the activation of the NOTCH1 signaling pathway. Furthermore, overexpression of NOTCH1 rescued the proliferation, migration, and invasion in papillary thyroid cancer cells. Taken together, our data indicated that CCAL promoted papillary thyroid cancer development and progression by activation of the NOTCH1 pathway, which provided a new insight on the design of therapeutic targets.

Upregulation of long noncoding RNA MALAT1 in papillary thyroid cancer and its diagnostic value

2018 ◽  
Vol 14 (29) ◽  
pp. 3015-3022 ◽  
Author(s):  
Jia Liu ◽  
Hanhua Dong ◽  
Yingxu Yang ◽  
Yuejun Qian ◽  
Jianqiu Liu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Diagnostic Value ◽  
Papillary Thyroid
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