5-Aza-2′-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line

2013 ◽  
Vol 28 (4) ◽  
pp. 343-350 ◽  
Author(s):  
Huihui Zhang ◽  
Fan Qi ◽  
Youhan Cao ◽  
Xiongbing Zu ◽  
Minfeng Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Line ◽  
Migration And Invasion ◽  
Maspin Expression ◽  
T24 Cell Line

scholarly journals Silencing of lncRNA MIR497HG via CRISPR/Cas13d Induces Bladder Cancer Progression Through Promoting the Crosstalk Between Hippo/Yap and TGF-β/Smad Signaling

2020 ◽  
Vol 7 ◽  
Author(s):  
Changshui Zhuang ◽  
Ying Liu ◽  
Shengqiang Fu ◽  
Chaobo Yuan ◽  
Jingwen Luo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Line ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Pathological Process ◽  
The Cancer Genome Atlas ◽  
Migration And Invasion

A subset of long non-coding RNAs (lncRNAs), categorized as miRNA-host gene lncRNAs (lnc-miRHGs), is processed to produce miRNAs and involved in cancer progression. This work aimed to investigate the influences and the molecular mechanisms of lnc-miRHGs MIR497HG in bladder cancer (BCa). The miR-497 and miR-195 were derived from MIR497HG. We identified that lnc-miRHG MIR497HG and two harbored miRNAs, miR-497 and miR-195, were downregulated in BCa by analyzing The Cancer Genome Atlas and our dataset. Silencing of MIR497HG by CRISPR/Cas13d in BCa cell line 5637 promoted cell growth, migration, and invasion in vitro. Conversely, overexpression of MIR497HG suppressed cell progression in BCa cell line T24. MiR-497/miR-195 mimics rescued significantly the oncogenic roles of knockdown of MIR497HG by CRISPR/Cas13d in BCa. Mechanistically, miR-497 and miR-195 co-ordinately suppressed multiple key components in Hippo/Yap and transforming growth factor β signaling and particularly attenuated the interaction between Yap and Smad3. In addition, E2F4 was proven to be critical for silencing MIR497HG transcription in BCa cells. In short, we propose for the first time to reveal the function and mechanisms of MIR497HG in BCa. Blocking the pathological process may be a potential strategy for the treatment of BCa.

RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line

2010 ◽  
Vol 200 (2) ◽  
pp. 110-119 ◽  
Author(s):  
Liping Ou ◽  
Yongcan Guo ◽  
Chunli Luo ◽  
Xiaohou Wu ◽  
Yi Zhao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Rna Interference ◽  
Cell Line ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
T24 Cell Line

scholarly journals TSLC1 inhibits bladder cancer cells proliferation and promotes apoptosis by targeting miR-125b

2020 ◽  
Author(s):  
Jun Zhu ◽  
Rui Hu ◽  
NingJing Ou ◽  
Zhen Liang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Line ◽  
Migration And Invasion ◽  
P53 Expression ◽  
Transwell Migration Assay ◽  
Migration Assay ◽  
Bladder Cancer Cells ◽  
Cancer Tissues ◽  
The Relationship

Abstract Backgroud: The aim of this study was to investigate the relationship between the expression of tumor suppressor in lung cancer-1 (TSLC1) and miRNA-125b in bladder cancer (BC) pathogenesis. Methods: The expression of miRNA-125b,TSLC1 and p53 in BC cell line was detected by real-time quantitative RT-PCR (RT-qPCR) or western blot. Transwell migration assay was used in the in vitro migration and invison anssay. TSLC1 and p53 expression was evaluated by immunohistochemistric staining in bladder cancer tissues. Results: We showed that the expression of miRNA-125b was significantly decreased in BC cell line(T24) transfection of miR-125b inhibitor.Knockdown of miRNA-125b promoted the growth and metastasis of T24 cells,while overexpression of miRNA-125b had the opposite effects. Furthermore,TSLC1 was significantly positive correlated with miRNA-125b expression and negative correlated with p53 expression in T24 cells.TSLC1 transfection increased the expression of miRNA-125b,and inhibited BC cell migration and invasion in vitro,and promoted apoptosis. The expression of TSLC1 and p53 was opposite in bladder cancer tissues. Conclusions: Our data provided strong evidence that TSLC1 inhibited tumorigenesis and development of BC through up-regulating tumor-suppressive miRNA-125b.

Methylene blue-conjugated gold nanoparticles enhanced photoimmunotherapy for bladder cancer in T24 cell line

2019 ◽  
Vol 18 (1) ◽  
pp. e1761-e1762
Author(s):  
C-W. Hsu ◽  
Y-C. Chiu ◽  
N-C. Cheng ◽  
M-Y. Liao ◽  
C-C. Huang
Keyword(s):  
Methylene Blue ◽  
Gold Nanoparticles ◽  
Bladder Cancer ◽  
Cell Line ◽  
T24 Cell Line

scholarly journals Arctigenin Anti-Tumor Activity in Bladder Cancer T24 Cell Line Through Induction of Cell-Cycle Arrest and Apoptosis

2012 ◽  
Vol 295 (8) ◽  
pp. 1260-1266 ◽  
Author(s):  
Shucai Yang ◽  
Jing Ma ◽  
Jianbing Xiao ◽  
Xiaohong Lv ◽  
Xinlei Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Bladder Cancer ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Cycle Arrest ◽  
T24 Cell Line ◽  
Anti Tumor Activity

scholarly journals Effect of sirolimus on urinary bladder cancer T24 cell line

2009 ◽  
Vol 28 (1) ◽  
pp. 3 ◽  
Author(s):  
Rosario Pinto-Leite ◽  
Pedro Botelho ◽  
Eufemia Ribeiro ◽  
Paula A Oliveira ◽  
Lucio Santos
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Cell Line ◽  
Urinary Bladder Cancer ◽  
T24 Cell Line

scholarly journals miR‑21 inhibits autophagy and promotes malignant development in the bladder cancer T24�cell line

2020 ◽  
Author(s):  
Hui‑Hui Zhang ◽  
Zhong‑Xin Huang ◽  
Su‑Quan Zhong ◽  
Kui‑Lin Fei ◽  
You‑Han Cao
Keyword(s):  
Bladder Cancer ◽  
Cell Line ◽  
T24 Cell Line

624: Usefulness of Cancer Vaccine Therapy Using Bladder Cancer Cell Line Introduced with Interleukin 21 Gene

2006 ◽  
Vol 175 (4S) ◽  
pp. 201-201 ◽  
Author(s):  
Isao Hara ◽  
Junya Furukawa ◽  
Kazuki Yamanaka ◽  
Yuji Yamada ◽  
Masato Fujisawa
Keyword(s):  
Bladder Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Vaccine ◽  
Cancer Cell Line ◽  
Bladder Cancer Cell ◽  
Vaccine Therapy ◽  
Bladder Cancer Cell Line ◽  
Interleukin 21

723: Chemokine Receptor CXCR4 Mediates Migration and Invasion of Bladder Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 192-192 ◽  
Author(s):  
Margitta Retz ◽  
Sukhvinder S. Sidhu ◽  
Gregory M. Dolganov ◽  
Jan Lehmann ◽  
Peter R. Carroll ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Chemokine Receptor ◽  
Migration And Invasion ◽  
Chemokine Receptor Cxcr4 ◽  
Bladder Cancer Cells
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