Down-Regulation of Survivin and Hypoxia-Inducible Factor-1α by β-elemene Enhances the Radiosensitivity of Lung Adenocarcinoma Xenograft

2012 ◽  
Vol 27 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Guoquan Li ◽  
Bingbing Xie ◽  
Xiaolong Li ◽  
Yinghai Chen ◽  
Qi Wang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Hypoxia Inducible Factor ◽  
Down Regulation ◽  
Hypoxia Inducible Factor 1Α

Abstract 383: Down-regulation of tumoral Hypoxia-Inducible Factor-1α expression in OVCAR-3 tumors by albendazole

2010 ◽  
Author(s):  
Mohammad H. Pourgholami ◽  
Zhao Yan Cai ◽  
Samina Badar ◽  
Marianne Poruchynsky ◽  
David Lawson Morris
Keyword(s):  
Hypoxia Inducible Factor ◽  
Down Regulation ◽  
Hypoxia Inducible Factor 1Α ◽  
Tumoral Hypoxia

Down-Regulation of Hypoxia-Inducible Factor-1α by Hyperbaric Oxygen Attenuates the Severity of Acute Pancreatitis in Rats

Pancreas ◽  
2009 ◽  
Vol 38 (5) ◽  
pp. 515-522 ◽  
Author(s):  
Xuewei Bai ◽  
Bei Sun ◽  
Shangha Pan ◽  
Hongchi Jiang ◽  
Feng Wang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Hyperbaric Oxygen ◽  
Hypoxia Inducible Factor ◽  
Down Regulation ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Cobalt Chloride-Induced Estrogen Receptor α Down-Regulation Involves Hypoxia-Inducible Factor-1α in MCF-7 Human Breast Cancer Cells

2005 ◽  
Vol 19 (5) ◽  
pp. 1191-1199 ◽  
Author(s):  
Jungyoon Cho ◽  
Dukkyung Kim ◽  
SeungKi Lee ◽  
YoungJoo Lee
Keyword(s):  
Estrogen Receptor ◽  
Protein Interactions ◽  
Cobalt Chloride ◽  
Active Form ◽  
Hypoxia Inducible Factor ◽  
Dependent Manner ◽  
Transactivation Domain ◽  
Down Regulation ◽  
Hypoxia Inducible Factor 1Α ◽  
Dependent Pathway

Abstract The estrogen receptor (ER) is down-regulated under hypoxia via a proteasome-dependent pathway. We studied the mechanism of ERα degradation under hypoxic mimetic conditions. Cobalt chloride-induced ERα down-regulation was dependent on the expression of newly synthesized protein(s), one possibility of which was hypoxia-inducible factor-1α (HIF-1α). To examine the role of HIF-1α expression in ERα down-regulation under hypoxic-mimetic conditions, we used a constitutively active form of HIF-1α, HIF-1α/herpes simplex viral protein 16 (VP16), constructed by replacing the transactivation domain of HIF-1α with that of VP16. Western blot analysis revealed that HIF-1α/VP16 down-regulated ERα in a dose-dependent manner via a proteasome-dependent pathway. The kinase pathway inhibitors PD98059, U0126, wortmannin, and SB203580 did not affect the down-regulation. A mammalian two-hybrid screen and immunoprecipitation assays indicated that ERα interacted with HIF-1α physically. These results suggest that ERα down-regulation under hypoxia involves protein-protein interactions between the ERα and HIF-1α.

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