Inhibition of Heme Oxygenase-1 Enhances the Radiosensitivity in Human Nonsmall Cell Lung Cancer A549 Cells

2011 ◽  
Vol 26 (5) ◽  
pp. 639-645 ◽  
Author(s):  
Wenyi Zhang ◽  
Tiankui Qiao ◽  
Lin Zha
Keyword(s):  
Lung Cancer ◽  
Heme Oxygenase ◽  
Cell Lung Cancer ◽  
A549 Cells ◽  
Nonsmall Cell Lung Cancer ◽  
Heme Oxygenase 1

Non-competitive heme oxygenase-1 activity inhibitor reduces non-small cell lung cancer glutathione content and regulates cell proliferation

2020 ◽  
Vol 47 (3) ◽  
pp. 1949-1964 ◽  
Author(s):  
Mariarita Spampinato ◽  
Giuseppe Sferrazzo ◽  
Valeria Pittalà ◽  
Michelino Di Rosa ◽  
Luca Vanella ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Small Cell Lung Cancer ◽  
Heme Oxygenase ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Heme Oxygenase 1 ◽  
Small Cell Lung

SAHA Treatment Reveals the Link between Histone Lysine Acetylation and Proteome in Nonsmall Cell Lung Cancer A549 Cells

2013 ◽  
Vol 12 (9) ◽  
pp. 4064-4073 ◽  
Author(s):  
Quan Wu ◽  
Weiqing Xu ◽  
Lejie Cao ◽  
Xin Li ◽  
Tieming He ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
A549 Cells ◽  
Nonsmall Cell Lung Cancer ◽  
Lysine Acetylation ◽  
Histone Lysine

scholarly journals Expression of MiR-608 in Nonsmall Cell Lung Cancer and Molecular Mechanism of Apoptosis and Migration of A549 Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Chu Huang ◽  
Weiming Yue ◽  
Lin Li ◽  
Shuhai Li ◽  
Cun Gao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
A549 Cells ◽  
Nonsmall Cell Lung Cancer ◽  
Control Group ◽  
Nsclc Tissue ◽  
Protein Levels ◽  
And Migration ◽  
Induced Apoptosis ◽  
Nsclc Patients

Objective. This Work is aimed at exploring the effect of microRNA (MiR)-608 on the function of nonsmall cell lung cancer (NSCLC) A549 cells and related mechanisms. Methods. Blood samples of 106 NSCLC patients (experimental group) as well as 124 normal people (control group) were selected for relevant investigation. Polymerase chain reaction (PCR) as well as DNA sequencing was used to determine the genotyping of the MiR-608 rs4919510 polymorphism. MiR-608 expression in cells was detected by real-time PCR technology. Western blotting was used to detect changes in protein levels. NSCLC tissues as well as adjacent tissues were explored in 33 patients undergoing surgery. Results. MiR-608 rs4919510 does not influence the incidence of NSCLC patients. In addition, MiR-608 expression was downregulated in the tumor tissue of NSCLC patients, while the transcription factor activating enhancer-binding protein 4 (TFAP4) expression was upregulated. MiR-608 promotes DOX- (Doxorubicin-) induced apoptosis by negatively regulating TFAP4 expression in NSCLC tissue. TFAP4 can significantly inhibit the migration of A549 cells. Conclusion. The findings in this investigation can contribute to the effective treatment of NSCLC patients. Also, the investigation can provide some theoretical support for the application of new targets for NSCLC treatment.

Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin

Lung Cancer ◽  
2008 ◽  
Vol 60 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Hak-Ryul Kim ◽  
Sejin Kim ◽  
Eun-Jung Kim ◽  
Jung-Hyun Park ◽  
Sei-Hoon Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Heme Oxygenase ◽  
A549 Cells ◽  
Heme Oxygenase 1

scholarly journals Apoptosis-Inducing Activity of Marine SpongeHaliclonasp. Extracts Collected from Kosrae in Nonsmall Cell Lung Cancer A549 Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Woori Bae ◽  
Hyun Kyung Lim ◽  
Kyoung Mee Kim ◽  
Hyosun Cho ◽  
Sun Yi Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Biological Activities ◽  
A549 Cells ◽  
Nonsmall Cell Lung Cancer ◽  
Marine Sponges ◽  
Caspase 8 ◽  
Anticancer Properties ◽  
Alternative Materials ◽  
Good Resource

Although various anticancer drugs have been developed for the treatment of nonsmall cell lung cancer, chemotherapeutic efficacy is still limited. Natural products such as phytochemicals have been screened as novel alternative materials, but alternative funds such as marine bioresources remain largely untapped. Of these resources, marine sponges have undergone the most scrutiny for their biological activities, including antiinflammatory, antiviral, and anticancer properties. However, the biological mechanisms of the activities of these marine sponges are still unclear. We investigated the anticancer activity of marine sponges collected from Kosrae in Micronesia and examined their mechanisms of action using nonsmall cell lung cancer A549 cells as a model system. Of 20 specimens, theHaliclonasp. (KO1304-328) showed both dose- and time-dependent cytotoxicity. Further, methanol extracts ofHaliclonasp. significantly inhibited cell proliferation and cell viability. A549 cells treated withHaliclonasp. demonstrated induced expression of c-Jun N-terminal kinase (JNK), p53, p21, caspase-8, and caspase-3. The percentage of apoptotic cells significantly increased in A549 cultures treated withHaliclonasp. These results indicate thatHaliclonasp. induces apoptosis via the JNK-p53 pathway and caspase-8, suggesting that this marine sponge is a good resource for the development of drugs for treatment of nonsmall cell lung cancer.

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