High Dose-Rate Endobronchial Radiotherapy for Proximal Airway Obstruction Due to Lung Cancer: 8-Year Experience of a Referral Center

2010 ◽  
Vol 25 (2) ◽  
pp. 207-213 ◽  
Author(s):  
Effrosyni D. Manali ◽  
Georgios T. Stathopoulos ◽  
Thomas R. Gildea ◽  
Peter Fleming ◽  
Julie Thornton ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Airway Obstruction ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Referral Center

Template-based high dose rate endobronchial brachytherapy for palliation of previously irradiated obstructive lung lesions.

2016 ◽  
Vol 34 (26_suppl) ◽  
pp. 174-174
Author(s):  
Brian A Hrycushko ◽  
Hsienchang Chiu ◽  
Michael Ryan Folkert
Keyword(s):  
Lung Cancer ◽  
Airway Obstruction ◽  
Dose Rate ◽  
Treatment Planning ◽  
Treatment Time ◽  
High Dose Rate ◽  
Planning System ◽  
External Beam Radiation ◽  
High Dose ◽  
Prescription Dose

174 Background: Local progression after external beam radiation therapy (RT) for lung cancer may result in clinical compromise from bleeding and/or airway obstruction, and additional RT may be precluded by radiation tolerance. High-dose-rate (HDR) endobronchial brachytherapy (EBT) is an effective salvage treatment for airway obstruction and/or bleeding, but requires significant time and resources; planning and treatment are performed bronchoscopically under anesthesia. We sought to reduce procedure and anesthesia time for EBT through template-based planning. Methods: EBT templates were created using the Brachyvision version 11.0.47 treatment planning system for the Varisource iX Ir-192 afterloader. Plans were optimized for dose uniformity at distance from the source following planning criteria of published works. Nine endobronchial centering tube templates were created for treatment lengths from 2-10 cm (1cm intervals) prescribed to 0.5cm distance from the applicator surface. Results: Standard EBT treatment requires a median of 47 minutes (range 44-49 minutes); 5 minutes for applicator placement and fluoroscopic confirmation, 15-17 minutes for plan design and optimization, 20 minutes for quality assurance and plan check, 2-5 minutes for radiation delivery, and 2 minutes for room clearance and applicator removal. Pre-planned templates were evaluated for plan quality, and achieved >90% of the prescription dose for the entire treatment length at the respective treatment depth. Changes to the prescription dose could be achieved through dwell time scaling. Changes to the prescription depth require re-optimization of the plan with the current templates as a base. Use of template-based planning was expected to reduce overall treatment time by 8-9 minutes (16-20% reduction in overall procedure time, 50-56% reduction in treatment planning time); median observed treatment time was 35 minutes (range 32-38 minutes). Conclusions: Template-based HDR EBT treatment plans were developed for the palliative lung cancer program at our institution. Implementation of template-based plans resulted in reduced procedure and operative time, and are now our standard technique.

scholarly journals Out-patient high-dose-rate endobronchial brachytherapy for palliation of lung cancer: an observational study

2016 ◽  
Vol 67 (3) ◽  
Author(s):  
A. Scarda ◽  
M. Confalonieri ◽  
C. Baghiris ◽  
S. Binato ◽  
R. Mazzarotto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Observational Study ◽  
Dose Rate ◽  
Malignant Tumour ◽  
High Dose Rate ◽  
Advanced Lung Cancer ◽  
High Dose ◽  
End Of Treatment ◽  
Co Morbidity ◽  
Central Airway

Background and Aim. Out-patient high-dose-rate endobronchial brachytherapy (HDREB) is a possible option in the palliation of symptoms in patients with advanced lung cancer, but literature data is limited and the technique is still under development in Italy. Our aim was to evaluate safety and effectiveness of out-patient HDREB for palliation of malignant endobronchial tumours in the context of a multidisciplinary approach. Methods. Out-patient HDREB sessions were scheduled at weekly intervals (500-1000 cGy per session) with prior Diodi-laser resection in some cases. Response was assessed bronchoscopically, clinically and functionally at the end of treatment and one month after the last HDREB session. Inclusion criteria was: histological evidence of malignant tumour not susceptible to surgical treatment for extension or co-morbidity. Results. 150 outpatient HDREB sessions were carried out on consecutive 35 patients (mean age 69 yrs, M/F 29/6) with symptoms due to central airway obstruction. A shortterm endoscopic response was observed in 15/28 patients. After delivering 2000 cGy dyspnoea decreased significantly. After one month cough decreased and haemoptysis disappeared. Palliation was obtained in all patients except one during. Lung function tests did not significantly improve after HDREB. No fatal complication occurred. A temporary radiation bronchitis was observed in six patients. Conclusions. This non-comparative, prospective observational study showed a palliative response of HDREB in most of patients with advanced endoluminal lung cancer. The safety of the procedure was good and the rate of non-fatal serious complications was very low.

High Dose Rate Brachytherapy for Nonmalignant Airway Obstruction

CHEST Journal ◽  
2003 ◽  
Vol 124 (4) ◽  
pp. 1605-1610 ◽  
Author(s):  
Baruch Brenner ◽  
Mordechai R. Kramer ◽  
Alan Katz ◽  
Rafael Feinmesser ◽  
Alina Brenner-Weissmann ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
High Dose Rate Brachytherapy

Percutaneous and endobronchial high dose rate brachytherapy for lung cancer

1996 ◽  
Author(s):  
M Imamura ◽  
T Murata ◽  
K Nagata ◽  
H Kojima ◽  
Y Aoki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
High Dose Rate Brachytherapy

Image-guided interstitial high-dose-rate brachytherapy for dose escalation in the radiotherapy treatment of locally advanced lung cancer: A single-institute experience

Brachytherapy ◽  
2019 ◽  
Vol 18 (6) ◽  
pp. 829-834
Author(s):  
Georgios Chatzikonstantinou ◽  
Nikolaos Zamboglou ◽  
Dimos Baltas ◽  
Konstantinos Ferentinos ◽  
Dimitra Bon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dose Rate ◽  
Dose Escalation ◽  
Locally Advanced ◽  
High Dose Rate ◽  
Advanced Lung Cancer ◽  
High Dose ◽  
Image Guided ◽  
Locally Advanced Lung Cancer ◽  
Radiotherapy Treatment
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