Gene Therapy for Human Nasopharyngeal Carcinoma by Adenovirus–Mediated Transfer of Human p53, GM-CSF, and B7-1 Genes in a Mouse Xenograft Tumor Model

2008 ◽  
Vol 23 (5) ◽  
pp. 591-602 ◽  
Author(s):  
Su-Ping Ren ◽  
Lan Wang ◽  
Hua Wang ◽  
Bin Wu ◽  
Ying Han ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nasopharyngeal Carcinoma ◽  
Tumor Model ◽  
Xenograft Tumor ◽  
Mouse Xenograft ◽  
Gm Csf ◽  
Human Nasopharyngeal Carcinoma ◽  
Xenograft Tumor Model

scholarly journals Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

2014 ◽  
Vol 3 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Reshmi Rajendran ◽  
Wei Huang ◽  
Annie Mei Yee Tang ◽  
Jie Ming Liang ◽  
Stephanie Choo ◽  
...  
Keyword(s):  
Early Detection ◽  
Tumor Model ◽  
Perfusion Mri ◽  
Xenograft Tumor ◽  
Antiangiogenic Treatment ◽  
Mouse Xenograft ◽  
Quantitative Perfusion ◽  
Xenograft Tumor Model ◽  
Treatment Responses

Abstract 2605: Mithramycin enhances the efficacy of etoposide in Ewing sarcoma cells and a mouse xenograft tumor model

2019 ◽  
Author(s):  
Anish Ray ◽  
Umesh T. Sankpal ◽  
Lina Albeer ◽  
Abigail Hunter ◽  
Holly Lout ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Tumor Model ◽  
Xenograft Tumor ◽  
Mouse Xenograft ◽  
Xenograft Tumor Model ◽  
Sarcoma Cells

Dynamic Contrast-Enhanced Folate-Receptor-Targeted MR Imaging Using a Gd-loaded PEG-Dendrimer–Folate Conjugate in a Mouse Xenograft Tumor Model

2009 ◽  
Vol 12 (2) ◽  
pp. 145-154 ◽  
Author(s):  
Wei-Tsung Chen ◽  
Dhakshanamurthy Thirumalai ◽  
Tiffany Ting-Fang Shih ◽  
Ran-Chou Chen ◽  
Shin-Yang Tu ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Folate Receptor ◽  
Tumor Model ◽  
Xenograft Tumor ◽  
Mouse Xenograft ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Xenograft Tumor Model ◽  
Folate Conjugate

Abstract 2605: Mithramycin enhances the efficacy of etoposide in Ewing sarcoma cells and a mouse xenograft tumor model

2019 ◽  
Author(s):  
Anish Ray ◽  
Umesh T. Sankpal ◽  
Lina Albeer ◽  
Abigail Hunter ◽  
Holly Lout ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Tumor Model ◽  
Xenograft Tumor ◽  
Mouse Xenograft ◽  
Xenograft Tumor Model ◽  
Sarcoma Cells

scholarly journals Combining Sodium Butyrate With Cisplatin Increases the Apoptosis of Gastric Cancer In Vivo and In Vitro via the Mitochondrial Apoptosis Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Yangbo Li ◽  
Pengzhan He ◽  
Yinghui Liu ◽  
Mingming Qi ◽  
Weiguo Dong
Keyword(s):  
Sodium Butyrate ◽  
Intestinal Flora ◽  
Tumor Model ◽  
Mitochondrial Apoptosis ◽  
Xenograft Tumor ◽  
Mouse Xenograft ◽  
Xenograft Tumor Model ◽  
Related Pathway

Introduction: The gastrointestinal malignancy, gastric cancer (GC), has a high incidence worldwide. Cisplatin is a traditional chemotherapeutic drug that is generally applied to treat cancer; however, drug tolerance affects its efficacy. Sodium butyrate is an intestinal flora derivative that has general anti-cancer effects in vitro and in vivo via pro-apoptosis effects and can improve prognosis in combination with traditional chemotherapy drugs. The present study aimed to assess the effect of sodium butyrate combined with cisplatin on GC.Methods: A Cell Counting Kit-8 assay was used to assess the viability of GC cells in vitro. Hoechst 33,258 staining and Annexin V-Phycoerythrin/7-Aminoactinomycin D were used to qualitatively and quantitatively detect apoptosis in GC cells. Intracellular reactive oxygen species (ROS) measurement and a mitochondrial membrane potential (MMP) assay kit were used to qualitatively and quantitatively reflect the function of mitochondria in GC cells. Western blotting was used to verify the above experimental results. A nude mouse xenograft tumor model was used to evaluate the anti-tumor efficacity of sodium and cisplatin butyrate in vivo.Results: Cisplatin combined with sodium butyrate increased the apoptosis of GC cells. In the nude mouse xenograft tumor model, sodium butyrate in combination with cisplatin markedly inhibited the growth of the tumor more effectively than either single agent. The combination of sodium butyrate and cisplatin increased the intracellular ROS, decreased the MMP, and suppressed the invasion and migration abilities of GC cells. Western blotting verified that the combination of sodium butyrate and cisplatin remarkably enhanced the levels of mitochondrial apoptosis-related pathway proteins.Conclusion: Sodium butyrate, a histone acetylation inhibitor produced by intestinal flora fermentation, combined with cisplatin enhanced the apoptosis of GC cells through the mitochondrial apoptosis-related pathway, which might be considered as a therapeutic option for GC.

Responsiveness of Human Prostate Carcinoma Bone Tumors to Interleukin-2 Therapy in a Mouse Xenograft Tumor Model

1999 ◽  
Vol 23 (5) ◽  
pp. 408-416 ◽  
Author(s):  
Sosa V. Kocheril ◽  
David J. Grignon ◽  
Ching Y. Wang ◽  
Richard L. Maughan ◽  
Emily J. Montecillo ◽  
...  
Keyword(s):  
Prostate Carcinoma ◽  
Bone Tumors ◽  
Interleukin 2 ◽  
Tumor Model ◽  
Human Prostate ◽  
Xenograft Tumor ◽  
Mouse Xenograft ◽  
Human Prostate Carcinoma ◽  
Xenograft Tumor Model

scholarly journals Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Qiong Zhong ◽  
Juncong Huang ◽  
Jiawang Wei ◽  
Renrui Wu
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Molecular Mechanism ◽  
Tumor Model ◽  
Circular Rna ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Institutional Research ◽  
Xenograft Tumor ◽  
Mice Model ◽  
Xenograft Tumor Model

Abstract Background Circular RNA (circRNA) CDR1as plays an important role in the occurrence and development of human tumors. The purpose of this study is to investigate the molecular mechanism of circRNA CDR1as in the development of nasopharyngeal carcinoma (NPC). Methods The mRNA expressions of circRNA CDR1as, miR-7-5p, and E2F3 were detected by qRT-PCR. The effects of circRNA CDR1as, miR-7-5p, and E2F3 on NPC cells were investigated using cell counting kit-8 (CCK8) method, colony formation assay, and representative metabolite assay. The molecular mechanism of circRNA CDR1 in NPC was studied by bioinformatics and luciferase reporter assay. In addition, the biological activity of circRNA CDR1as was also investigated in NPC xenograft tumor mice model. Results The results showed that the circRNA CDR1as expression was significantly up-regulated in NPC tissues by comparison with non-tumor NPE tissues (p < 0.01), suggesting that circRNA CDR1as was associated with poor prognosis in NPC patients. Moreover, circRNA CDR1as could up-regulate E2F3 expression by binding miR-7-5p, and promote the growth and glucose metabolism of NPC cells. Meanwhile, circRNA CDR1as could promote NPC progression through the negative regulation of miR-7-5p in the xenograft tumor model. Conclusion CircRNA CDR1as promoted the occurrence and development of NPCs by successively up-regulating the expression of miR-7-5p and E2F3, suggesting CircRNA CDR1as as a potential target for the treatment of NPC patients. Trial registration The study was approved by the cancer center’s institutional research ethics committee on Oct 18, 2008 (2008GZ2847462)

Antitumor Activity of γδ T Cells Reactive against Cytomegalovirus-Infected Cells in a Mouse Xenograft Tumor Model

2009 ◽  
Vol 69 (9) ◽  
pp. 3971-3978 ◽  
Author(s):  
Christel Devaud ◽  
Eric Bilhere ◽  
Séverine Loizon ◽  
Vincent Pitard ◽  
Charlotte Behr ◽  
...  
Keyword(s):  
T Cells ◽  
Antitumor Activity ◽  
Γδ T Cells ◽  
Tumor Model ◽  
Xenograft Tumor ◽  
Mouse Xenograft ◽  
Xenograft Tumor Model ◽  
Infected Cells
Sign in / Sign up

Export Citation Format

Share Document