scholarly journals Unremitting Impulsive Aggression in a Child with Childhood Onset Schizophrenia and Pervasive Development Disorder-Not Otherwise Specified: The Role of Stimulants, Atypical Antipsychotics and Mood Stabilizers

2013 ◽  
Vol 23 (5) ◽  
pp. 363-366 ◽  
Author(s):  
Presenter: Sarper Taskiran ◽  
Discussant: Barbara J. Coffey
Keyword(s):  
Atypical Antipsychotics ◽  
Mood Stabilizers ◽  
Childhood Onset ◽  
Not Otherwise Specified ◽  
Impulsive Aggression ◽  
Childhood Onset Schizophrenia ◽  
Pervasive Development Disorder

scholarly journals Parietal Lobes in Schizophrenia: Do They Matter?

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Murat Yildiz ◽  
Stefan J. Borgwardt ◽  
Gregor E. Berger
Keyword(s):  
English Language ◽  
Grey Matter ◽  
Parietal Lobe ◽  
Genetic Disorders ◽  
Childhood Onset ◽  
Parietal Lobes ◽  
Childhood Onset Schizophrenia ◽  
Patients At Risk ◽  
Occipital Lobes

Objective. Despite observations that abnormal parietal lobe (PL) function is associated with psychotic-like experiences, our knowledge about the nature of PL involvement in schizophrenia is modest. The objective of this paper is to investigate the role of the PL in schizophrenia.Method. Medline databases were searched for English language publications using the following key words: parietal lobe, combined with schizophrenia, lesions, epilepsy, cognition, rare genetic disorders, MRI, fMRI, PET, and SPECT, respectively, followed by cross-checking of references.Results. Imaging studies in childhood onset schizophrenia suggest that grey matter abnormalities start in parietal and occipital lobes and proceed to frontal regions. Although, the findings are inconsistent, several studies with patients at risk to develop schizophrenia indicate early changes in the PL.Conclusions. We want to propose that in a proportion of individuals with emerging schizophrenia structural and functional alterations may start in the PL and progress to frontal regions.

Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified

2004 ◽  
Vol 55 (10) ◽  
pp. 976-980 ◽  
Author(s):  
Anjené M Addington ◽  
Michele Gornick ◽  
Alexandra L Sporn ◽  
Nitin Gogtay ◽  
Deanna Greenstein ◽  
...  
Keyword(s):  
Childhood Onset ◽  
Not Otherwise Specified ◽  
Childhood Onset Schizophrenia

Anti-Myelin Oligodendrocyte Glycoprotein Encephalomyelitis and Extensive Longitudinal Transverse Myelitis Associated with Compound Heterozygous NLRP3 Missense Mutations in a Young Child

2020 ◽  
Author(s):  
Deirdre O'Sullivan ◽  
Michael Moore ◽  
Susan Byrne ◽  
Andreas O. Reiff ◽  
Susanna Felsenstein
Keyword(s):  
Young Child ◽  
Genetic Basis ◽  
Transverse Myelitis ◽  
Acute Disseminated Encephalomyelitis ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Compound Heterozygous ◽  
Missense Mutations ◽  
Childhood Onset

AbstractAcute disseminated encephalomyelitis in association with extensive longitudinal transverse myelitis is reported in a young child with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody with heterozygous NLRP3 missense mutations; p.(Arg488Lys) and p.(Ser159Ile). This case may well present an exceptional coincidence, but may describe a yet unrecognized feature of the spectrum of childhood onset cryopyrinopathies that contribute to the understanding of the genetic basis for anti-MOG antibody positive encephalomyelitis. Based on this observation, a larger scale study investigating the role of NLRP3 and other inflammasomes in this entity would provide important pathophysiological insights and potentially novel avenues for treatment.

The Role of Atypical Antipsychotics in Sexuality: Road to Recovery in Schizophrenia

2018 ◽  
Vol 19 (12) ◽  
pp. 1402-1411 ◽  
Author(s):  
Raja Lope Adam ◽  
Hatta Sidi ◽  
Marhani Midin ◽  
Hazli Zakaria ◽  
Srijit Das ◽  
...  
Keyword(s):  
Atypical Antipsychotics

scholarly journals National record-linkage study of hospital admissions for schizophrenia in childhood and adolescence in England

2021 ◽  
Author(s):  
Olena Seminog ◽  
Uy Hoang ◽  
Michael Goldacre ◽  
Anthony James
Keyword(s):  
Hospital Admissions ◽  
Population Based ◽  
Linkage Study ◽  
Incidence Rates ◽  
Childhood And Adolescence ◽  
Childhood Onset ◽  
Affective Psychosis ◽  
Health Service Provision ◽  
Childhood Onset Schizophrenia ◽  
Icd 10

Abstract Background There is a lack of information on changes in hospital admission rates for childhood-onset schizophrenia (COS), or on patient characteristics, to inform clinical research and health service provision. Aims To report age- and sex-specific incidence rates of hospital admissions and day patient care for schizophrenia (ICD-10 F20) and non-affective psychosis (ICD-10 F20-29), by year of occurrence and age, in childhood and adolescence. Methods Population-based study using person-linked data for England (available 2001–2016); time-periods in single years and 4-year groups. Results Hospitalised incidence for schizophrenia increased with increasing age, from 0.03 (95% confidence interval (CI) 0.02–0.05) and 0.01 (0–0.01) per 100,000 in, respectively, males and females aged 5–12 years, to 3.67 (3.44–3.91) in males and 1.58 (1.43–1.75) in females aged 13–17 years. There was no gender difference in hospitalised incidence rates in children aged 5–12, but in 13–17 years old, there was a male excess. Rates for schizophrenia were stable over time in 5–12 years old. In ages 13–17, rates for schizophrenia decreased between 2001–2004 and 2013–2016 in males, from 6.65 (6.04–7.31) down to 1.40 (1.13–1.73), and in females from 2.42 (2.05–2.83) to 1.18 (0.92–1.48). The hospitalisation rates for schizophrenia and non-affective psychosis, combined, in 13–17 years old decreased in males from 14.20 (13.30–15.14) in 2001–2004 to 10.77 (9.97–11.60) in 2013–2016, but increased in females from 7.49 (6.83–8.20) to 10.16 (9.38–11.00). Conclusions The study confirms that childhood-onset schizophrenia is extremely rare, with only 32 cases identified over a 15-year period in the whole of England. The incidence of schizophrenia and non-affective psychosis increased substantially in adolescence; however, the marked reduction in the proportion of those diagnosed with schizophrenia in this age group suggests a possible change in diagnostic practice.

Role of Atypical Antipsychotics in the Treatment of Generalized Anxiety Disorder

CNS Drugs ◽  
2014 ◽  
Vol 28 (6) ◽  
pp. 519-533 ◽  
Author(s):  
Rachel Hershenberg ◽  
Daniel F. Gros ◽  
Olga Brawman-Mintzer
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Atypical Antipsychotics ◽  
Generalized Anxiety
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