scholarly journals Single-Dose Pharmacokinetics of Methylphenidate Extended-Release Multiple Layer Beads Administered as Intact Capsule or Sprinkles Versus Methylphenidate Immediate-Release Tablets (Ritalin®) in Healthy Adult Volunteers

2014 ◽  
Vol 24 (10) ◽  
pp. 570-578 ◽  
Author(s):  
Akwete Adjei ◽  
Nathan S. Teuscher ◽  
Robert J. Kupper ◽  
Wei-Wei Chang ◽  
Laurence Greenhill ◽  
...  
Keyword(s):  
Single Dose ◽  
Extended Release ◽  
Healthy Adult ◽  
Immediate Release ◽  
Multiple Layer ◽  
Adult Volunteers

Steady-State Bioavailability of Extended-Release Methylphenidate (MPH-MLR) Capsule vs. Immediate-Release Methylphenidate Tablets in Healthy Adult Volunteers

2014 ◽  
Vol 34 (11) ◽  
pp. 795-805 ◽  
Author(s):  
Akwete Adjei ◽  
Robert J. Kupper ◽  
Nathan S. Teuscher ◽  
Sharon Wigal ◽  
Floyd Sallee ◽  
...  
Keyword(s):  
Steady State ◽  
Extended Release ◽  
Healthy Adult ◽  
Immediate Release ◽  
Adult Volunteers

Bioavailability of once-daily venlafaxine extended release compared with the immediate-release formulation in healthy adult volunteers

1997 ◽  
Vol 58 (8) ◽  
pp. 492-503 ◽  
Author(s):  
Steven M. Troy ◽  
Clifford Dilea ◽  
Patrick T. Martin ◽  
Amy S. Rosen ◽  
Richard J. Fruncillo ◽  
...  
Keyword(s):  
Extended Release ◽  
Healthy Adult ◽  
Immediate Release ◽  
Release Formulation ◽  
Once Daily ◽  
Adult Volunteers

A Single-Dose, Two-Way Crossover, Open-Label Bioequivalence Study of an Amphetamine Extended-Release Oral Suspension in Healthy Adults

2017 ◽  
Vol 24 (3) ◽  
pp. 414-419 ◽  
Author(s):  
Carolyn Sikes ◽  
Jeffrey G. Stark ◽  
Russ McMahen ◽  
Dorothy Engelking
Keyword(s):  
Single Dose ◽  
Extended Release ◽  
Healthy Adult ◽  
Bioequivalence Study ◽  
Oral Suspension ◽  
Pharmacokinetic Parameters ◽  
Open Label ◽  
Adult Participants ◽  
Study Results ◽  
Adult Volunteers

Objective: The purpose of this study was to compare the pharmacokinetics of a new extended-release amphetamine oral suspension (AMP XR-OS) with a standard extended-release mixed amphetamine salts product, Adderall XR®. Method: In this single-dose, open-label, randomized, two-period, two-treatment crossover study, 42 healthy adult volunteers received 15 mL of AMP XR-OS in one period and a 30 mg Adderall XR capsule in another period (both containing 18.8 mg of amphetamine base) under fasted conditions. Blood samples were analyzed for d- and l-amphetamine concentrations, and pharmacokinetic parameters Cmax, AUC0-5, AUC5-last, and AUCinf were calculated to determine bioequivalence. Safety was monitored throughout the study. Results: The 90% confidence intervals (CIs) for the log-transformed Cmax, AUC0-5, AUC5-last, and AUCinf fell within the accepted 80% to 125% range for establishing bioequivalence for d- and l-amphetamine. The most common adverse events were nausea and decreased appetite. Conclusion: AMP XR-OS is bioequivalent to Adderall XR in healthy adult participants.

Assessment Of Adverse Events After MNK-795 (Oxycodone And Acetaminophen Extended-Release Tablets) In Healthy Adult Volunteers

2014 ◽  
Vol 46 ◽  
pp. 808
Author(s):  
Srinivas R. Nalamachu ◽  
Thomas Barrett ◽  
Terri Morton ◽  
Kenneth Kostenbader ◽  
Michael Giuliani ◽  
...  
Keyword(s):  
Adverse Events ◽  
Extended Release ◽  
Healthy Adult ◽  
Adult Volunteers

The Single-Dose Pharmacokinetics of Clopidogrel in Healthy Adult Volunteers

2003 ◽  
Vol 73 (2) ◽  
pp. P47-P47
Author(s):  
J. Grenier ◽  
S. Ciric ◽  
J. Curry ◽  
G. Morelli ◽  
A. Arseneault ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Adult ◽  
Adult Volunteers
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