Bipolar Co-morbidity in Pediatric Obsessive-Compulsive Disorder: Clinical and Treatment Implications

2007 ◽  
Vol 17 (4) ◽  
pp. 475-486 ◽  
Author(s):  
Gabriele Masi ◽  
Giulio Perugi ◽  
Stefania Millepiedi ◽  
Cristina Toni ◽  
Maria Mucci ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Co Morbidity

scholarly journals Demography and symptom severity of obsessive compulsive disorder in Bangladesh: a cross-sectional observation

2020 ◽  
Vol 30 (2) ◽  
pp. 23-26
Author(s):  
Sultana Algin ◽  
Mohammad Waliul Hasnat Sajib ◽  
SM Yasir Arafat
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Symptom Severity ◽  
Large Scale ◽  
Depressive Disorders ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Co Morbidity ◽  
Study Results ◽  
Axis I

Obsessive Compulsive Disorder (OCD) is a common disorder and usually runs a chronic course with waxing and waning course. It leads to pervasive impairments in multiple domains of life. The aim of the study was to assess the demographic characteristics of the OCD patients and symptom severity of this disorder. This was a cross-sectional study done in OCD clinic of outpatient department (OPD) of BSMMU, during the period from May, 2015 to April, 2017. Four hundred patients fulfilling the inclusion and exclusion criteria were selected consecutively. After taking written consent a predetermined questionnaire was filled for each patient through face-to-face interview. Then patients were evaluated covering the following areas: Axis I diagnoses (DSM-IV) and Y-BOCS severity scale. The results showed that, the mean age of the respondents was 26.6 (SD±9.9) years, ranging from 8 to 63 years. According to Y-BOCS symptoms severity used for adult patients found that majority (70%) of the patients had moderate to severe sufferings. Male had co-morbid anxiety disorders (panic disorder, agoraphobia, social phobia) more but female patients were found more depressive disorders. Female had more hypothyroidism, diabetes, skin disorders and hypertension than male. These demographic status, co-morbidity profile and symptoms severity can serve as the baseline data for a country like Bangladesh and further large scale, multi-centered study would better generalize the study results. Bang J Psychiatry December 2016; 30(2): 23-26

scholarly journals Obsessive–compulsive disorder: subclassification based on co-morbidity

2008 ◽  
Vol 39 (9) ◽  
pp. 1491-1501 ◽  
Author(s):  
G. Nestadt ◽  
C. Z. Di ◽  
M. A. Riddle ◽  
M. A. Grados ◽  
B. D. Greenberg ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Obsessive Compulsive Disorder ◽  
Clinical Characteristics ◽  
Latent Class ◽  
Age At Onset ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Co Morbidity ◽  
The Relationship

BackgroundObsessive–compulsive disorder (OCD) is probably an etiologically heterogeneous condition. Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes.MethodSeven hundred and six individuals with OCD were assessed in the OCD Collaborative Genetics Study (OCGS). Multi-level latent class analysis was conducted based on the presence of eight co-morbid psychiatric conditions [generalized anxiety disorder (GAD), major depression, panic disorder (PD), separation anxiety disorder (SAD), tics, mania, somatization disorders (Som) and grooming disorders (GrD)]. The relationship of the derived classes to specific clinical characteristics was investigated.ResultsTwo and three classes of OCD syndromes emerge from the analyses. The two-class solution describes lesser and greater co-morbidity classes and the more descriptive three-class solution is characterized by: (1) an OCD simplex class, in which major depressive disorder (MDD) is the most frequent additional disorder; (2) an OCD co-morbid tic-related class, in which tics are prominent and affective syndromes are considerably rarer; and (3) an OCD co-morbid affective-related class in which PD and affective syndromes are highly represented. The OCD co-morbid tic-related class is predominantly male and characterized by high conscientiousness. The OCD co-morbid affective-related class is predominantly female, has a young age at onset, obsessive–compulsive personality disorder (OCPD) features, high scores on the ‘taboo’ factor of OCD symptoms, and low conscientiousness.ConclusionsOCD can be classified into three classes based on co-morbidity. Membership within a class is differentially associated with other clinical characteristics. These classes, if replicated, should have important implications for research and clinical endeavors.

scholarly journals Schizophrenia with Obsessive Compulsive Symptoms: A Case Report

2019 ◽  
Vol 8 (1) ◽  
pp. 66-67
Author(s):  
A Jha ◽  
D Joshi
Keyword(s):  
Case Report ◽  
Obsessive Compulsive Disorder ◽  
Poor Response ◽  
Clinical Impact ◽  
Anti Psychotic ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Co Morbidity

Obsessive-compulsive disorder/ symptoms may be co-morbid in schizophrenia. The clinical impact of this co-morbidity is poor response to anti-psychotic medications. We present a case of 35 yr old female who presented with symptoms suggestive of schizophrenia and later co-morbid obsessive symptom responded well to addition of fluoxetine to antipsychotics. This case study reveals that the identification and treatment of OCD in schizophrenia is very crucial for optimistic outcome.

Co-morbid obsessive–compulsive disorder and depression: a Bayesian network approach

2017 ◽  
Vol 47 (7) ◽  
pp. 1204-1214 ◽  
Author(s):  
R. J. McNally ◽  
P. Mair ◽  
B. L. Mugno ◽  
B. C. Riemann
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Directed Acyclic Graph ◽  
Hill Climbing ◽  
Depression Symptoms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Hill Climbing Algorithm ◽  
Graphical Lasso ◽  
Co Morbidity ◽  
The Relationship

BackgroundObsessive–compulsive disorder (OCD) is often co-morbid with depression. Using the methods of network analysis, we computed two networks that disclose the potentially causal relationships among symptoms of these two disorders in 408 adult patients with primary OCD and co-morbid depression symptoms.MethodWe examined the relationship between the symptoms constituting these syndromes by computing a (regularized) partial correlation network via the graphical LASSO procedure, and a directed acyclic graph (DAG) via a Bayesian hill-climbing algorithm.ResultsThe results suggest that the degree of interference and distress associated with obsessions, and the degree of interference associated with compulsions, are the chief drivers of co-morbidity. Moreover, activation of the depression cluster appears to occur solely through distress associated with obsessions activating sadness – a key symptom that ‘bridges’ the two syndromic clusters in the DAG.ConclusionsBayesian analysis can expand the repertoire of network analytic approaches to psychopathology. We discuss clinical implications and limitations of our findings.

scholarly journals Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample

2007 ◽  
Vol 65 (4a) ◽  
pp. 936-941 ◽  
Author(s):  
Karen Miguita ◽  
Quirino Cordeiro ◽  
Jacqueline Siqueira-Roberto ◽  
Roseli Gedanke Shavitt ◽  
José Carlos Ramos Castillo ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Obsessive Compulsive Disorder ◽  
Age At Onset ◽  
Tic Disorders ◽  
Transporter Gene ◽  
Obsessive Compulsive ◽  
Dopamine Transporter Gene ◽  
Brazilian Sample ◽  
Compulsive Disorder ◽  
Co Morbidity

Family, twin and segregation analysis have provided evidences that genetic factors are implicated in the susceptibility for obsessive-compulsive disorder (OCD). Several lines of research suggest that the dopaminergic system may be involved in the pathophysiology of OCD. Thus, the aim of the present study was to investigate a possible association between a polymorphism located in intron 8 of the dopamine transporter gene (SLC6A3) and OCD in a Brazilian sample composed by 208 patients and 865 healthy controls. No statistically differences were observed in allelic and genotype distributions between cases and controls. No association was also observed when the sample was divided according to specific phenotypic features such as gender, presence of tic disorders co-morbidity and age at onset of obsessive-compulsive symptoms (OCS). Our results suggest that the intron 8 VNTR of the SLC6A3 investigated in this study is not related to the susceptibility for OCD in our Brazilian sample.

The Overlap of Obsessive-Compulsive Disorder and Social Phobia and its Treatment

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S14) ◽  
pp. 47-53 ◽  
Author(s):  
David S. Baldwin ◽  
Emma K. Brandish ◽  
Daniel Meron
Keyword(s):  
Social Phobia ◽  
Obsessive Compulsive Disorder ◽  
Epidemiological Studies ◽  
Primary Diagnosis ◽  
Comorbid Condition ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Optimal Outcomes ◽  
Co Morbidity ◽  
Pharmacologic Management

AbstractBoth obsessive-compulsive disorder (OCD) and social phobia are common in community and clinical settings, and it should be expected that a proportion of patients with one of these conditions will also fulfill either current or lifetime criteria for the other condition. However, comorbid social phobia is more common among patients with a primary diagnosis of OCD than is comorbid OCD in patients with a primary diagnosis of social phobia. This article explores the extent of the association of OCD and social phobia in epidemiological studies, and examines the possible role of underlying depression and other disorders in mediating the appearance of the comorbid condition. Although there have been no published randomized controlled trials in patients with this particular pattern of co-morbidity, it seems sensible to adopt pharmacologic and psychologic treatment approaches which have been found efficacious in both OCD and social phobia. Pharmacologic management therefore centers on first-line treatment with a selective serotonin reuptake inhibitor. Psychologic intervention should draw on the range of cognitive and behavioral approaches required for optimal outcomes in OCD and social phobia, as discrete conditions.

Co-morbid Obsessive-compulsive Disorder and Bipolar Disorder in Highly Endogamous Population: Which Came First?

2017 ◽  
Vol 41 (S1) ◽  
pp. S119-S119
Author(s):  
A. Bener
Keyword(s):  
Bipolar Disorder ◽  
Obsessive Compulsive Disorder ◽  
Rating Scale ◽  
Obsessive Compulsive ◽  
Young Mania ◽  
Compulsive Disorder ◽  
Oppositional Defiant ◽  
Co Morbidity ◽  
Endogamous Population ◽  
The Impact

The aim of this study was to determine the prevalence of co-morbidity with obsessive-compulsive disorder (OCD) among bipolar disorder (BD) patients in order to assess the impact of OCD on the socio-demographic and clinical features of patients in a highly endogamous population. A cohort study was carried out on 396 patients enrolled between November 2011 to October 2013. We employed the WHO Composite International Diagnostic Interview (WHO-CIDI) and Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-IV/Clinical Version for diagnoses, the Yale-Brown Obsessive Compulsive Scale Symptom Checklist for scoring OCD. Patients were grouped in BD patients with OCD (BD-OCD) and BD patients without OCD.Groups were compared for socio-demographic and clinical variables. There were no significant differences for age, gender, BMI, and marital status, between BD patients with and without OCD. We found significant differences in level of education (P = 0.022), occupation status (P = 0.025), household income, (P = 0.049), cigarette smoking (P = 0.038), sheesha smoking (P = 0.007), and prevalence of consanguinity (P = 0.036) among these groups. Number of hospitalizations and Young Mania Rating Scale score were not different among BD patients with or without OCD whereas there were significant differences in Hamilton-Depression score, Clinical Global Impression-BD Score, duration of illnesses, and Global Assessment of Functioning (GAF). Also specific phobia, somatization, depression, mania, any mood disorder, oppositional defiant disorder, ADHD and personality disorder were more common in BD than OCD–BD group. This study confirms that BD-OCD is a common co-morbidity, largely under-recognized in clinical practice, which may significantly change BD presentation and outcome.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

Saccadic abnormalities in psychotropic-naive obsessive–compulsive disorder without co-morbidity

2006 ◽  
Vol 36 (9) ◽  
pp. 1321-1326 ◽  
Author(s):  
NIC J. van der WEE ◽  
HANS H. HARDEMAN ◽  
NICK F. RAMSEY ◽  
MATHIJS RAEMAEKERS ◽  
HAROLD J. VAN MEGEN ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Biological Marker ◽  
Error Rates ◽  
Antisaccade Task ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Co Morbidity ◽  
Normal Error ◽  
Fixation Task ◽  
Oriented Research

Background. Oculomotor studies have found saccadic abnormalities in obsessive–compulsive disorder (OCD), lending support for models postulating a central role for inhibition in OCD. Saccadic abnormalities in OCD may also be potential candidates for a biological marker, important for more endophenotype-oriented research. Saccadic abnormalities have not been examined in psychotropic-naive patients with OCD without co-morbidity.Method. We compared the error rates and latencies of 14 carefully selected adult psychotropic-naive patients with OCD with no co-morbid diagnosis and 14 pairwise matched healthy controls on a fixation task, on a prosaccade task and on an antisaccade task.Results. Patients with OCD showed normal error rates on all tasks, but latencies on the antisaccade task were significantly increased.Conclusions. Our results indicate that patients with OCD have no gross impairment of oculomotor inhibitory capacities, but may have a disturbed capacity to deliberately initiate a saccade to an imagined target.

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