Combination Treatment with Clomipramine and Selective Serotonin Reuptake Inhibitors for Obsessive-Compulsive Disorder in Children and Adolescents

1998 ◽  
Vol 8 (1) ◽  
pp. 61-67 ◽  
Author(s):  
YVETTE FIGUEROA ◽  
DAVID R. ROSENBERG ◽  
BORIS BIRMAHER ◽  
MATCHERI S. KESHAVAN
Keyword(s):  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Combination Treatment ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Selective Serotonin Reuptake Inhibitors for the Treatment of Obsessive-Compulsive Disorder in Children and Adolescents

2003 ◽  
Vol 8 (3) ◽  
pp. 177-186
Author(s):  
Jennifer Schoelles Williams ◽  
Thea Moore ◽  
Candace L. Collins ◽  
Kerry-Ann E. Thomas
Keyword(s):  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Major Advance ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Pediatric Psychiatry

The introduction of the selective serotonin reuptake inhibitors (SSRIs) has been a major advance in pediatric psychiatry, while contemporary advances in the understanding of obsessive-compulsive disorder (OCD) phenomenon in children have facilitated its identification and treatment. Currently, fluvoxamine and sertraline are the only SSRIs that have received FDA approval for the treatment of childhood OCD. The purpose of this article is to review the safety and efficacy of SSRIs in the treatment of obsessive-compulsive disorder (OCD) in children and adolescents.

Quetiapine Augmentation of Selective Serotonin Reuptake Inhibitors in Treatment-Resistant Obsessive-Compulsive Disorder: A Six-Month Follow-Up Case Series

CNS Spectrums ◽  
2006 ◽  
Vol 11 (11) ◽  
pp. 879-883 ◽  
Author(s):  
Bernardo Dell'Osso ◽  
Emanuela Mundo ◽  
A. Carlo Altamura
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Case Series ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

ABSTRACTObsessive-compulsive disorder (OCD) is a relatively common, often chronic and disabling disorder with high rates of partial and/or absent response to standard, recommended treatments, such as selective serotonin reuptake inhibitors (SSRIs) and psychotherapy. This article presents the cases of four patients suffering from OCD and comorbid mood or anxiety disorders, who were treated with SSRIs at adequate doses for at least 12 weeks, showing a partial response. Quetiapine treatment was added to SSRIs at a dose of 25 mg/day and titrated up to 200 mg/day. Patients were followed up for 6 months. After 12 weeks, all the patients were classified as “much improved” on the Clinical Global Impression–Improvement scale and showed a Yale-Brown Obsessive-Compulsive Scale score reduction ≥35%. After 6 months of follow-up, all the patients maintained the same level of improvement. Although quetiapine augmentation to SSRIs has shown mixed results in published controlled trials in the acute treatment (12 weeks) of patients with treatment-resistant OCD, this case series indicates that patients who benefit from this pharmacologic regimen in the acute phase tend to maintain such an improvement. Larger follow-up studies are warranted to confirm our findings.

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