Do Subtle Neurological Impairments Predict Treatment Resistance to Clomipramine in Children and Adolescents with Obsessive-Compulsive Disorder?

1990 ◽  
Vol 1 (2) ◽  
pp. 133-140 ◽  
Author(s):  
JOHN S. MARCH ◽  
HUGH JOHNSTON ◽  
JAMES W. JEFFERSON ◽  
KENNETH A. KOBAK ◽  
JOHN H. GREIST
Keyword(s):  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Treatment Resistance ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Obsessive-compulsive disorder in children and adolescents: epidemiology, diagnosis and management

2020 ◽  
Vol 9 (S1) ◽  
pp. S76-S93
Author(s):  
Ahsan Nazeer ◽  
Finza Latif ◽  
Aisha Mondal ◽  
Muhammad Waqar Azeem ◽  
Donald E. Greydanus
Keyword(s):  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Diagnosis And Management

Treatment Resistance in Obsessive-Compulsive Disorder

2018 ◽  
pp. 165-177 ◽  
Author(s):  
Rachel Middleton ◽  
Michael G. Wheaton ◽  
Reilly Kayser ◽  
H. Blair Simpson
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Treatment Resistance ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals The prevalence of autism spectrum traits and autism spectrum disorders in children and adolescents with obsessive compulsive disorder: a systematic review

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S56-S56
Author(s):  
Claire Tiley ◽  
Marinos Kyriakopoulos
Keyword(s):  
Systematic Review ◽  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Functional Impairment ◽  
Body Dysmorphic Disorder ◽  
Autism Spectrum ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Global Functioning ◽  
Compulsive Disorder

AimsAutism Spectrum Disorder (ASD) and Obsessive Compulsive Disorder (OCD) commonly co-occur in children and adolescents (C&A); evidence suggests functional impairment is increased in those diagnosed with both disorders. The aims of this systematic review were: 1) To review studies that report on the prevalence of ASD traits and/or diagnosis in C&A with OCD. 2) To review whether the severity of OCD symptoms is related to the severity of ASD traits in C&A with OCD. 3)To review whether the severity of comorbid ASD traits or diagnosis in C&A with OCD impact on their global functioning.MethodThis systematic review was registered in PROSPERO. Prisma guidelines were followed . Electronic searches were carried out on Pubmed, EMBASE and Psychinfo with the use of selected keywords. Inclusion criteria : 1) Participants up to the age of 18 who had an ICD or DSM diagnosis of OCD. 2) Journal articles published in the English, with no date specifications. 3) Papers evaluating ASD diagnosis or traits, or where data on this could be extracted. Exclusion criteria: 1) Papers looking at OCD related disorders such as body dysmorphic disorder, compulsive skin picking, trichotillomania and hoarding disorder. 2) Samples including adults where C&A data could not be extracted. 3) Posters, abstracts and dissertations.ResultA total of 15 studies were included in the systematic review. Seven of these studies directly compared the prevalence of ASD traits (measured by questionnaires) or diagnosis in OCD to a control group or normative data, with all studies reporting a significant elevation in ASD trait scores and diagnosis in OCD. Ten of the studies reported on the correlation between ASD trait severity and OCD severity. Four studies identified a significant correlation between ASD and OCD total scores or specified subscales. In contrast, one study found significantly elevated OCD scores in an OCD only group when compared to a comorbid OCD and ASD group. Three studies reported on the correlation between ASD scores and functional impairment or compared an OCD only group to a comorbid group. All three studies demonstrated that the presence ASD or ASD traits are associated with elevated scores in global functional impairment.ConclusionIn conclusion, this review suggests that there is an increased prevalence of ASD traits and diagnosis amongst C&A with OCD. Elevated ASD traits within this population are associated with a greater impact on global functioning.

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