Regional strength of large-scale functional brain networks is associated with regional volumes in older adults and in Alzheimer’s disease

2020 ◽  
Author(s):  
Giuseppe Sarli ◽  
Matteo De Marco ◽  
Merja Hallikainen ◽  
Hilkka Soininen ◽  
Giuseppe Bruno ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Large Scale ◽  
Brain Networks ◽  
Functional Brain ◽  
Functional Brain Networks

scholarly journals Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

2021 ◽  
Vol 11 (11) ◽  
pp. 1535
Author(s):  
Hui Zhang ◽  
Edward S. Hui ◽  
Peng Cao ◽  
Henry K. F. Mak
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Networks ◽  
Amyloid Β ◽  
Potential Candidate ◽  
Functional Brain ◽  
Specific Effects ◽  
Functional Brain Networks

Previous studies have demonstrated that the accumulation of amyloid-β (Aβ) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer’s disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better characterization of the stage-specific effects of Aβ pathologies. A potential candidate for this joint characterization is the coupling between the structural and functional brain networks (SC-FC coupling). We therefore investigated the effect of Aβ accumulation on global SC-FC coupling in patients with mild cognitive impairment (MCI), AD, and healthy controls. Patients with MCI were dichotomized according to their level of Aβ pathology seen in 18F-flutemetamol PET-CT scans—namely, Aβ-negative and Aβ-positive. Our results show that there was no difference in global SC-FC coupling between different cohorts. During the prodromal AD stage, there was a significant negative correlation between the level of Aβ pathology and the global SC-FC coupling of MCI patients with positive Aβ, but no significant correlation for MCI patients with negative Aβ. During the AD dementia stage, the correlation between Aβ pathology and global SC-FC coupling in patients with AD was positive. Our results suggest that Aβ pathology has distinctive stage-specific effects on global coupling between the structural and functional brain networks along the AD continuum.

Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease

2021 ◽  
Vol 72 ◽  
pp. 101482
Author(s):  
Lorenzo Pini ◽  
Alexandra M. Wennberg ◽  
Alessandro Salvalaggio ◽  
Antonino Vallesi ◽  
Michela Pievani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Networks ◽  
Functional Brain ◽  
Functional Brain Networks ◽  
Clinical Variants

scholarly journals Tau Pathology Distribution in Alzheimer's disease Corresponds Differentially to Cognition-Relevant Functional Brain Networks

2017 ◽  
Vol 11 ◽  
Author(s):  
Oskar Hansson ◽  
Michel J. Grothe ◽  
Tor Olof Strandberg ◽  
Tomas Ohlsson ◽  
Douglas Hägerström ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Networks ◽  
Tau Pathology ◽  
Functional Brain ◽  
Functional Brain Networks

scholarly journals Altered Weibull degree distribution in resting‐state functional brain networks in Alzheimer’s disease

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Yifei Zhang ◽  
Xuhong Liao ◽  
Xiaodan Chen ◽  
Xinyuan Liang ◽  
Zhijiang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Resting State ◽  
Degree Distribution ◽  
Brain Networks ◽  
Functional Brain ◽  
Functional Brain Networks

scholarly journals The older adult brain is less modular, more integrated and less efficient at rest: A systematic review of large-scale resting-state functional brain networks across the adult lifespan.

2021 ◽  
Author(s):  
Hamish Deery ◽  
Rober Di Paolo ◽  
Chris Moran ◽  
Gary F. Egan ◽  
Sharna Jamadar
Keyword(s):  
Older Adults ◽  
Age Differences ◽  
Resting State ◽  
Large Scale ◽  
Brain Networks ◽  
Adult Brain ◽  
Functional Brain ◽  
Adult Lifespan ◽  
Age Related ◽  
Functional Brain Networks

The literature on large-scale resting-state functional brain networks across the adult lifespan was systematically reviewed. Studies published between 1986 and July 2021 were retrieved from PubMed. After reviewing 2,938 records, 144 studies were included. Results on 11 network measures were summarised and assessed for certainty of the evidence using a modified GRADE method. The evidence provides high certainty that older adults display reduced within-network and increased between-network functional connectivity. Older adults also show lower segregation, modularity, efficiency and hub function. Higher-order networks reliably showed age differences, whereas basic processing and control networks showed more variable results. The inflection point for network changes is often the third or fourth decade of life. Age effects were found with moderate certainty for increased hemispheric lateralisation at rest, reduced BOLD signal variability within-subjects and altered patterns and speed of dynamic connectivity. Research on connectivity using glucose uptake provides low certainty of age differences but warrants further study. Taken together, these age-related changes may contribute to the cognitive decline often seen in older adults.

Sign in / Sign up

Export Citation Format

Share Document