scholarly journals Effect of Dopaminergic Medications on Blood Oxygen Level-Dependent Variability and Functional Connectivity in Parkinson's Disease and Healthy Aging

2019 ◽  
Vol 9 (7) ◽  
pp. 554-565 ◽  
Author(s):  
Trevor K.M. Day ◽  
Tara M. Madhyastha ◽  
Adél Lee ◽  
Cyrus P. Zabetian ◽  
Thomas J. Montine ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Healthy Aging ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level

Symptom-specific differential motor network modulation by deep brain stimulation in Parkinson’s disease

2021 ◽  
pp. 1-9
Author(s):  
William S. Gibson ◽  
Aaron E. Rusheen ◽  
Yoonbae Oh ◽  
Myung-Ho In ◽  
Krzysztof R. Gorny ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Adverse Effects ◽  
Primary Motor Cortex ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Deep Brain

OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established neurosurgical treatment for the motor symptoms of Parkinson’s disease (PD). While often highly effective, DBS does not always yield optimal therapeutic outcomes, and stimulation-induced adverse effects, including paresthesia, muscle contractions, and nausea/lightheadedness, commonly occur and can limit the efficacy of stimulation. Currently, objective metrics do not exist for monitoring neural changes associated with stimulation-induced therapeutic and adverse effects. METHODS In the present study, the authors combined intraoperative functional MRI (fMRI) with STN DBS in 20 patients with PD to test the hypothesis that stimulation-induced blood oxygen level–dependent signals contained predictive information concerning the therapeutic and adverse effects of stimulation. RESULTS As expected, DBS resulted in blood oxygen level–dependent activation in myriad motor regions, including the primary motor cortex, caudate, putamen, thalamus, midbrain, and cerebellum. Across the patients, DBS-induced improvements in contralateral Unified Parkinson’s Disease Rating Scale tremor subscores correlated with activation of thalamic, brainstem, and cerebellar regions. In addition, improvements in rigidity and bradykinesia subscores correlated with activation of the primary motor cortex. Finally, activation of specific sensorimotor-related subregions correlated with the presence of DBS-induced adverse effects, including paresthesia and nausea (cerebellar cortex, sensorimotor cortex) and unwanted muscle contractions (caudate and putamen). CONCLUSIONS These results suggest that DBS-induced activation patterns revealed by fMRI contain predictive information with respect to the therapeutic and adverse effects of DBS. The use of fMRI in combination with DBS therefore may hold translational potential to guide and improve clinical stimulator optimization in patients.

Multiple Sclerosis: Low-Frequency Temporal Blood Oxygen Level–Dependent Fluctuations Indicate Reduced Functional Connectivity—Initial Results

Radiology ◽  
2002 ◽  
Vol 224 (1) ◽  
pp. 184-192 ◽  
Author(s):  
Mark J. Lowe ◽  
Micheal D. Phillips ◽  
Joseph T. Lurito ◽  
David Mattson ◽  
Mario Dzemidzic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Functional Connectivity ◽  
Low Frequency ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Initial Results

scholarly journals Predicting Task and Subject Differences with Functional Connectivity and Blood-Oxygen-Level-Dependent Variability

2019 ◽  
Vol 9 (6) ◽  
pp. 451-463 ◽  
Author(s):  
Garren Gaut ◽  
Brandon Turner ◽  
Zhong-Lin Lu ◽  
Xiangrui Li ◽  
William A. Cunningham ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Subject Differences

scholarly journals Covert neurofeedback without awareness shapes cortical network spontaneous connectivity

2016 ◽  
Vol 113 (17) ◽  
pp. E2413-E2420 ◽  
Author(s):  
Michal Ramot ◽  
Shany Grossman ◽  
Doron Friedman ◽  
Rafael Malach
Keyword(s):  
Visual Cortex ◽  
Functional Connectivity ◽  
Functional Mri ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Neurofeedback Training ◽  
Learning Situation ◽  
Blood Oxygen Level ◽  
Training Effects

Recent advances in blood oxygen level-dependent–functional MRI (BOLD-fMRI)-based neurofeedback reveal that participants can modulate neuronal properties. However, it is unknown whether such training effects can be introduced in the absence of participants' awareness that they are being trained. Here, we show unconscious neurofeedback training, which consequently produced changes in functional connectivity, introduced in participants who received positive and negative rewards that were covertly coupled to activity in two category-selective visual cortex regions. The results indicate that brain networks can be modified even in the complete absence of intention and awareness of the learning situation, raising intriguing possibilities for clinical interventions.

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