scholarly journals Disruption of Functional Brain Networks in Alzheimer's Disease: What Can We Learn from Graph Spectral Analysis of Resting-State Magnetoencephalography?

2012 ◽  
Vol 2 (2) ◽  
pp. 45-55 ◽  
Author(s):  
Willem de Haan ◽  
Wiesje M. van der Flier ◽  
Huijuan Wang ◽  
Piet F.A. Van Mieghem ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spectral Analysis ◽  
Resting State ◽  
Brain Networks ◽  
Functional Brain ◽  
Functional Brain Networks

scholarly journals Altered Weibull degree distribution in resting‐state functional brain networks in Alzheimer’s disease

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Yifei Zhang ◽  
Xuhong Liao ◽  
Xiaodan Chen ◽  
Xinyuan Liang ◽  
Zhijiang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Resting State ◽  
Degree Distribution ◽  
Brain Networks ◽  
Functional Brain ◽  
Functional Brain Networks

scholarly journals Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

2021 ◽  
Vol 11 (11) ◽  
pp. 1535
Author(s):  
Hui Zhang ◽  
Edward S. Hui ◽  
Peng Cao ◽  
Henry K. F. Mak
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Networks ◽  
Amyloid Β ◽  
Potential Candidate ◽  
Functional Brain ◽  
Specific Effects ◽  
Functional Brain Networks

Previous studies have demonstrated that the accumulation of amyloid-β (Aβ) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer’s disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better characterization of the stage-specific effects of Aβ pathologies. A potential candidate for this joint characterization is the coupling between the structural and functional brain networks (SC-FC coupling). We therefore investigated the effect of Aβ accumulation on global SC-FC coupling in patients with mild cognitive impairment (MCI), AD, and healthy controls. Patients with MCI were dichotomized according to their level of Aβ pathology seen in 18F-flutemetamol PET-CT scans—namely, Aβ-negative and Aβ-positive. Our results show that there was no difference in global SC-FC coupling between different cohorts. During the prodromal AD stage, there was a significant negative correlation between the level of Aβ pathology and the global SC-FC coupling of MCI patients with positive Aβ, but no significant correlation for MCI patients with negative Aβ. During the AD dementia stage, the correlation between Aβ pathology and global SC-FC coupling in patients with AD was positive. Our results suggest that Aβ pathology has distinctive stage-specific effects on global coupling between the structural and functional brain networks along the AD continuum.

Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease

2021 ◽  
Vol 72 ◽  
pp. 101482
Author(s):  
Lorenzo Pini ◽  
Alexandra M. Wennberg ◽  
Alessandro Salvalaggio ◽  
Antonino Vallesi ◽  
Michela Pievani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Networks ◽  
Functional Brain ◽  
Functional Brain Networks ◽  
Clinical Variants

scholarly journals Tau Pathology Distribution in Alzheimer's disease Corresponds Differentially to Cognition-Relevant Functional Brain Networks

2017 ◽  
Vol 11 ◽  
Author(s):  
Oskar Hansson ◽  
Michel J. Grothe ◽  
Tor Olof Strandberg ◽  
Tomas Ohlsson ◽  
Douglas Hägerström ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Networks ◽  
Tau Pathology ◽  
Functional Brain ◽  
Functional Brain Networks
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