scholarly journals Cost and Cost-Effectiveness of Donor Human Milk to Prevent Necrotizing Enterocolitis: Systematic Review

2017 ◽  
Vol 12 (9) ◽  
pp. 528-536 ◽  
Author(s):  
Abigail Buckle ◽  
Celia Taylor
Keyword(s):  
Systematic Review ◽  
Cost Effectiveness ◽  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Donor Human Milk

scholarly journals Donor Human Milk Protects against Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis

Nutrients ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 238 ◽  
Author(s):  
Eduardo Villamor-Martínez ◽  
Maria Pierro ◽  
Giacomo Cavallaro ◽  
Fabio Mosca ◽  
Boris Kramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Milk ◽  
Bronchopulmonary Dysplasia ◽  
Meta Analysis ◽  
Donor Human Milk

scholarly journals Donor Human Milk Protects against Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis

2018 ◽  
Author(s):  
Eduardo Villamor-Martínez ◽  
Maria Pierro ◽  
Giacomo Cavallaro ◽  
Fabio Mosca ◽  
Boris W. Kramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Milk ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Observational Studies ◽  
Meta Analysis ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Donor Human Milk ◽  
Preterm Formula

Bronchopulmonary dysplasia (BPD) is the most common complication after preterm birth. Pasteurized donor human milk (DHM) has increasingly become the standard of care for very preterm infants over the use of preterm formula (PF) if mother’s own milk (MOM) is unavailable. Studies have reported beneficial effects of DHM on BPD. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies on the effects of DHM on BPD and other respiratory outcomes. Eighteen studies met the inclusion criteria. Meta-analysis of RCT’s could not demonstrate that supplementation of MOM with DHM reduced BPD when compared to PF (3 studies, risk ratio [RR] 0.89, 95% confidence interval [CI] 0.60–1.32). However, meta-analysis of observational studies showed that DHM supplementation reduced BPD (8 studies, RR 0.78, 95% CI 0.67–0.90). An exclusive human milk diet reduced the risk of BPD, compared to a diet with PF and/or bovine milk-based fortifier (3 studies, RR 0.80, 95% CI 0.68–0.95). Feeding raw MOM, compared to feeding pasteurized MOM, protected against BPD (2 studies, RR 0.77, 95% CI 0.62–0.96). In conclusion, our data suggest that DHM protects against BPD in very preterm infants, but pasteurization of human milk reduces the benefit.

Availability of Donor Human Milk Decreases the Incidence of Necrotizing Enterocolitis in VLBW Infants

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Morris Cohen ◽  
Eileen Steffen ◽  
Randi Axelrod ◽  
Shalini N. Patel ◽  
Krystyna Toczylowski ◽  
...  
Keyword(s):  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Vlbw Infants ◽  
Donor Human Milk

scholarly journals The Nutritional Composition and Energy Content of Donor Human Milk: A Systematic Review

2020 ◽  
Vol 11 (4) ◽  
pp. 960-970 ◽  
Author(s):  
Maryanne T Perrin ◽  
Mandy B Belfort ◽  
James I Hagadorn ◽  
Jacqueline M McGrath ◽  
Sarah N Taylor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Milk ◽  
Energy Content ◽  
Feeding Strategy ◽  
Nutritional Composition ◽  
Conclusive Evidence ◽  
Sources Of Information ◽  
Donor Human Milk ◽  
Information Bias ◽  
The Impact

ABSTRACT The American Academy of Pediatrics recommends donor human milk (DHM) as the preferred feeding strategy for preterm infants when the milk of the mother is unavailable, based on conclusive evidence of lower rates of necrotizing enterocolitis with DHM feedings compared with preterm infant formula. The nutritional composition of DHM may differ from maternal milk for many reasons including differences in maternal characteristics, milk collection methods, and the impact of donor milk banking practices. The purpose of this systematic review is to examine the literature regarding research on the fat, protein, carbohydrate, vitamin, and mineral composition of DHM obtained through nonprofit milk banks or commercial entities. PubMed, CINAHL, and Scopus databases were searched for articles published between 1985 and 30 April, 2019. In total, 164 abstracts were screened independently by 2 investigators, and 14 studies met all inclusion criteria. Studies were predominantly small (<50 samples) and measured macronutrients. Few studies assessed vitamins and minerals. Information bias was prevalent due to the use of a variety of analytical methods which influence accuracy and cross-study comparisons. Other sources of information bias included missing information regarding methods for protein and calorie assessment. Despite these limitations, existing research suggests the potential for 2-fold and greater differences in the fat, protein, and energy composition of DHM, with mean values for energy and fat often below clinical reference values expected for human milk. Further research is warranted regarding the nutritional composition of DHM, with a prioritization on measuring macronutrients and micronutrients using established reference methods.

Pasteurized donor human milk for VLBW infants: The effect on necrotizing enterocolitis and related factors

2010 ◽  
Vol 3 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Christine E. Bishop ◽  
Margarita M. Vasquez ◽  
Jean A. Petershack ◽  
Cynthia L. Blanco
Keyword(s):  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Related Factors ◽  
Vlbw Infants ◽  
Donor Human Milk
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