The Role of Bariatric Surgery in Patients with Obesity and Type 1 Diabetes Mellitus

2020 ◽  
Vol 15 (1) ◽  
pp. 46-50
Author(s):  
Gustavo Fernandez-Ranvier ◽  
Aryan Meknat ◽  
Daniela E. Guevara ◽  
Naif Alenazi ◽  
Hugo Ruiz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bariatric Surgery ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus

The role of bariatric surgery in patients with type 1 diabetes mellitus

2021 ◽  
Vol 75 (6) ◽  
pp. 524-528
Author(s):  
Dita Pichlerová
Keyword(s):  
Diabetes Mellitus ◽  
Bariatric Surgery ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Retrospective Studies ◽  
Current Knowledge ◽  
Case Reports

Bariatric surgery procedures are recognized as the most successful method of treating diabetes in obese patients with type 2 diabetes mellitus. Despite the fact that the number of obese type 1 diabetics has been constantly increasing in the last decade, bariatric surgery in these patients is still waiting to be widely used and standardized. Bariatric surgery has been proposed as an effective treatment for these patients, although data are scarce, based on case reports and retrospective studies. The article summarizes the current knowledge about the use of bariatric surgery in type 1 diabetics with obesity an cites some of the previous studies. Bariatric surgery is not yet routinely recommended in patients with type 1 diabetes mellitus.

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

2016 ◽  
Vol 174 (4) ◽  
pp. R127-R138 ◽  
Author(s):  
F S Hough ◽  
D D Pierroz ◽  
C Cooper ◽  
S L Ferrari ◽  
_ _
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Bone Fragility ◽  
Mineral Density ◽  
Good Glycaemic Control ◽  
Marrow Adiposity ◽  
Igf1 Deficiency

Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased bone resorption. Insulin/IGF1 deficiency appears to be a major pathogenetic mechanism involved, along with glucose toxicity, marrow adiposity, inflammation, adipokine and other metabolic alterations that may all play a role on altering bone turnover. In turn, increasing physical activity in children with diabetes as well as good glycaemic control appears to provide some improvement of bone parameters, although robust clinical studies are still lacking. In this context, the role of osteoporosis drugs remains unknown.

Clinical and socio-demographic determinants of inadequate self-care in adults with type 1 diabetes mellitus: the leading role of self-care confidence

2018 ◽  
Vol 56 (2) ◽  
pp. 151-161 ◽  
Author(s):  
Rosario Caruso ◽  
Paola Rebora ◽  
Federica Dellafiore ◽  
Diletta Fabrizi ◽  
Barbara Riegel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Self Care ◽  
Leading Role

Role of free insulin-like growth factor-I in hyperglycemia in patients with type 1 diabetes mellitus

2000 ◽  
Vol 50 ◽  
pp. 417
Author(s):  
Kisho Kobayashi ◽  
Shin Amemiya ◽  
Koji Kobayashi ◽  
Mie Mochizuki ◽  
Tomoaki Sano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Free Insulin ◽  
Growth Factor I

scholarly journals The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus

2013 ◽  
Vol 57 (9) ◽  
pp. 667-676 ◽  
Author(s):  
Ana Paula Bouças ◽  
Fernanda dos Santos de Oliveira ◽  
Luis Henrique Canani ◽  
Daisy Crispim
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Metabolic Decompensation ◽  
Viral Pathogens ◽  
Autoimmune Destruction ◽  
Infected Cells ◽  
Rna And Dna

Type 1 diabetes mellitus (T1DM) is a chronic, progressive, autoimmune disease characterized by metabolic decompensation frequently leading to dehydration and ketoacidosis. Viral pathogens seem to play a major role in triggering the autoimmune destruction that leads to the development of T1DM. Among several viral strains investigated so far, enteroviruses have been consistently associated with T1DM in humans. One of the mediators of viral damage is the double-stranded RNA (dsRNA) generated during replication and transcription of viral RNA and DNA. The IFIH1 gene encodes a cytoplasmic receptor of the pattern-recognition receptors (PRRs) family that recognizes dsRNA, playing a role in the innate immune response triggered by viral infection. Binding of dsRNA to this PRR triggers the release of proinflammatory cytokines, such as interferons (IFNs), which exhibit potent antiviral activity, protecting uninfected cells and inducing apoptosis of infected cells. The IFIH1 gene appears to play a major role in the development of some autoimmune diseases, and it is, therefore, a candidate gene for T1DM. Within this context, the objective of the present review was to address the role of IFIH1 in the development of T1DM.

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