Peri/Epicellular Thiol Oxidoreductases as Mediators of Extracellular Redox Signaling

2020 ◽  
Vol 33 (4) ◽  
pp. 280-307 ◽  
Author(s):  
Leonardo Y. Tanaka ◽  
Percillia V.S. Oliveira ◽  
Francisco R.M. Laurindo
Keyword(s):  
Redox Signaling ◽  
Thiol Oxidoreductases

scholarly journals Novel and Converging Ways of NOX2 and SOD3 in Trafficking and Redox Signaling in Macrophages

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 172
Author(s):  
Steen Vang Petersen ◽  
Nanna Bach Poulsen ◽  
Cecilie Linneberg Matthiesen ◽  
Frederik Vilhardt
Keyword(s):  
Hydrogen Peroxide ◽  
Membrane Trafficking ◽  
Spatial Organization ◽  
Redox Signaling ◽  
Small Gtpase ◽  
Paracrine Signaling ◽  
Tissue Macrophage ◽  
Storage Vesicles ◽  
Superoxide Dismutase 3 ◽  
Macrophage Populations

Macrophages and related tissue macrophage populations use the classical NADPH oxidase (NOX2) for the regulated production of superoxide and derived oxidants for pathogen combat and redox signaling. With an emphasis on macrophages, we discuss how sorting into secretory storage vesicles, agonist-responsive membrane trafficking, and segregation into sphingolipid and cholesterol-enriched microdomains (lipid rafts) determine the subcellular distribution and spatial organization of NOX2 and superoxide dismutase-3 (SOD3). We discuss how inflammatory activation of macrophages, in part through small GTPase Rab27A/B regulation of the secretory compartments, mediates the coalescence of these two proteins on the cell surface to deliver a focalized hydrogen peroxide output. In interplay with membrane-embedded oxidant transporters and redox sensitive target proteins, this arrangement allows for the autocrine and paracrine signaling, which govern macrophage activation states and transcriptional programs. By discussing examples of autocrine and paracrine redox signaling, we highlight why formation of spatiotemporal microenvironments where produced superoxide is rapidly converted to hydrogen peroxide and conveyed immediately to reach redox targets in proximal vicinity is required for efficient redox signaling. Finally, we discuss the recent discovery of macrophage-derived exosomes as vehicles of NOX2 holoenzyme export to other cells.

scholarly journals Redox Regulation of Lipid Mobilization in Adipose Tissues

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1090
Author(s):  
Ursula Abou-Rjeileh ◽  
G. Andres Contreras
Keyword(s):  
Adipose Tissue ◽  
Energy Metabolism ◽  
Redox Regulation ◽  
Cellular Metabolism ◽  
Antioxidant Response ◽  
Redox Signaling ◽  
Nitrogen Species ◽  
Adipose Tissues ◽  
Lipid Mobilization ◽  
Cellular Processes

Lipid mobilization in adipose tissues, which includes lipogenesis and lipolysis, is a paramount process in regulating systemic energy metabolism. Reactive oxygen and nitrogen species (ROS and RNS) are byproducts of cellular metabolism that exert signaling functions in several cellular processes, including lipolysis and lipogenesis. During lipolysis, the adipose tissue generates ROS and RNS and thus requires a robust antioxidant response to maintain tight regulation of redox signaling. This review will discuss the production of ROS and RNS within the adipose tissue, their role in regulating lipolysis and lipogenesis, and the implications of antioxidants on lipid mobilization.

Oxidative stress in phenylketonuria—evidence from human studies and animal models, and possible implications for redox signaling

2021 ◽  
Vol 36 (4) ◽  
pp. 523-543
Author(s):  
Vanessa Trindade Bortoluzzi ◽  
Carlos Severo Dutra Filho ◽  
Clovis Milton Duval Wannmacher
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Redox Signaling ◽  
Human Studies

scholarly journals Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration

2014 ◽  
Vol 207 (5) ◽  
pp. 589-598 ◽  
Author(s):  
Sebastien Tauzin ◽  
Taylor W. Starnes ◽  
Francisco Barros Becker ◽  
Pui-ying Lam ◽  
Anna Huttenlocher
Keyword(s):  
Tissue Regeneration ◽  
Tissue Damage ◽  
Redox Signaling ◽  
Kinase Signaling ◽  
Src Family Kinase ◽  
Reverse Migration ◽  
Early Recruitment

Tissue damage induces early recruitment of neutrophils through redox-regulated Src family kinase (SFK) signaling in neutrophils. Redox-SFK signaling in epithelium is also necessary for wound resolution and tissue regeneration. How neutrophil-mediated inflammation resolves remains unclear. In this paper, we studied the interactions between macrophages and neutrophils in response to tissue damage in zebrafish and found that macrophages contact neutrophils and induce resolution via neutrophil reverse migration. We found that redox-SFK signaling through p22phox and Yes-related kinase is necessary for macrophage wound attraction and the subsequent reverse migration of neutrophils. Importantly, macrophage-specific reconstitution of p22phox revealed that macrophage redox signaling is necessary for neutrophil reverse migration. Thus, redox-SFK signaling in adjacent tissues is essential for coordinated leukocyte wound attraction and repulsion through pathways that involve contact-mediated guidance.

scholarly journals Exercise shapes redox signaling in cancer

Redox Biology ◽  
2020 ◽  
Vol 35 ◽  
pp. 101439 ◽  
Author(s):  
Mohamad Assi ◽  
Suzanne Dufresne ◽  
Amélie Rébillard
Keyword(s):  
Redox Signaling

scholarly journals Dissecting the role of redox signaling in neuronal development

2016 ◽  
Vol 137 (4) ◽  
pp. 506-517 ◽  
Author(s):  
Daniel A. Bórquez ◽  
Pamela J. Urrutia ◽  
Carlos Wilson ◽  
Brigitte van Zundert ◽  
Marco Tulio Núñez ◽  
...  
Keyword(s):  
Neuronal Development ◽  
Redox Signaling
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